Results 201 to 210 of about 52,420 (290)

Oncogenic receptor tyrosine kinase signaling is driven by the Golgi protein GOLPH3 and its interaction with MYO18A. [PDF]

Sci Signal
Starost KA, Bommi JR, Peterman MC, McCullough MX, Buschman MD, Yun B, Field SJ.   +6 more
europepmc   +1 more source

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

MedComm, Volume 7, Issue 9, September 2026.
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen   +6 more
wiley   +1 more source

SHP2 as a pivotal modulator of the tumor microenvironment in gastrointestinal cancers: from mechanisms to targeted therapies. [PDF]

J Transl Med
Wang S, Zhao X, Dong J, Zhang J, Wang Y, Jin H, Jiang X, Chen L, Zhang M, Ji L, Zhao Y.   +10 more
europepmc   +1 more source

Skekkjur í RTK-drónamælingum

Notkun dróna við landmælingar hefur aukist verulega á síðustu árum og eru slík gögn í dag mikilvægur grunnur fyrir hönnun og ákvarðanatöku. Þrátt fyrir miklar framfarir í búnaði og hugbúnaði, sérstaklega með tilkomu RTK, geta ýmsar skekkjur myndast í ...
Jóhann Karl Farestveit 2000-
core  

Isocitrate Dehydrogenase (IDH) Mutations in Hematological Malignancies: Epidemiology, Mechanisms, and Therapeutic Strategies

MedComm – Future Medicine, Volume 5, Issue 3, September 2026.
IDH mutation is an important event in hematological malignancies. This review systematically integrates the basic mechanism of IDH mutations and combines it with the clinical translation of related research progress. It also discusses the application strategies of IDH inhibitors and feasible research directions, with the aim of providing a theoretical ...
Jinkun Xu, Haiying Bai, Lijuan Hu
wiley   +1 more source

EGFR endocytosis down-regulates binding to EphA2 at the plasma membrane. [PDF]

J Biol Chem
Rybak JA, Barrera FN.
europepmc   +1 more source

Monoallelic SH2B1 Variants in Neurodevelopmental Disorders: Phenotypic Expansion and Functional Characterization of Rare Variants

Molecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.
This study delineates the clinical spectrum associated with rare monoallelic SH2B1 variants in individuals with NDDs. Functional analyses suggest variant‐specific effects on protein expression, subcellular localization, and ERK signaling responses.
Xin Xu, Gege Yuan, Bixia Zheng, Chunli Wang, Wei Zhou, Songming Huang, Senjie Du, Yikang He   +7 more
wiley   +1 more source

Deciphering RTK-RAS and MAPK Pathway Dependencies in Gemcitabine-Treated Pancreatic Ductal Adenocarcinoma Through Conversational Artificial Intelligence. [PDF]

Int J Mol Sci
Diaz FC, Waldrup B, Carranza FG, Manjarrez S, Velazquez-Villarreal E.   +4 more
europepmc   +1 more source

Comparative Analysis of RTK and Net-RTK Accuracy in UAV-Based Photogrammetry

The Eurasia Proceedings of Science Technology Engineering and Mathematics
Alkan, Öykü, Alzubade, Muntaha Kassim, Alkan, Mehmet Nurullah   +2 more
openaire   +2 more sources

Integrative Multi‐Omics Profiling Reveals Age‐Associated Genomic and Tumor Microenvironmental Heterogeneity in Colorectal Cancer

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Integrated multi‐omics analysis defines an age‐resolved molecular–immune framework in colorectal cancer. Early‐onset tumors show reduced APC/KRAS alterations, frequent SMAD4 disruption, enriched PTPRK–RSPO3 fusions, and increased CD4+ memory T cells and mast cells with greater checkpoint responsiveness.
Yang Guo, Yajiao He, Tao Zhou, Haidong Zhang, Fei Liao, Yuelan Wang, Hai‐Ning Chen, Li‐Bin Huang, Xuyang Xia, Yiqi Deng, Jing Wu, Siyu Yang, Heng Xu, Zong‐Guang Zhou, Yang Shu, Lie Yang   +15 more
wiley   +1 more source