Results 31 to 40 of about 2,314 (174)

Feature-Aided RTK/LiDAR/INS Integrated Positioning System with Parallel Filters in the Ambiguity-Position-Joint Domain for Urban Environments

Remote Sensing, 2021
As the modern navigation business evolves, demands for high-precision positioning in GNSS-challenged environments increase, and the integrated system composed of Global Navigation Satellite System (GNSS)-based Real-Time Kinematic (RTK), inertial system ...
Wenyi Li, Gang Liu, Xiaowei Cui, Mingquan Lu   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Comparative assessment of the application of RTK and non-RTK unmanned aerial vehicle technologies in mine surveying practice with accuracy control based on a geodetic control point network

Технічна інженерія
The paper presents the results of a comprehensive comparative analysis of the application of RTK and non-RTK UAVs for mine surveying monitoring of open-pit mining operations.
O.A. Yanovych, V.V. Kotenko
doaj   +1 more source

Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis. [PDF]

PLoS Genetics, 2015
The successive events that cells experience throughout development shape their intrinsic capacity to respond and integrate RTK inputs. Cellular responses to RTKs rely on different mechanisms of regulation that establish proper levels of RTK activation ...
Yannan Fan, Sylvie Richelme, Emilie Avazeri, Stéphane Audebert, Françoise Helmbacher, Rosanna Dono, Flavio Maina   +6 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Автоматическая генерация аннотаций научных статей на основе больших языковых моделей

Информатика и автоматизация
Предложена концепция автоматизации процесса аннотирования научных материалов (русскоязычных научных статей) и выполнена ее практическая реализация посредством технологий машинного обучения, дообучения больших языковых моделей.
Andrey Golubinskiy, Andrey Tolstykh, Marina Tolstykh   +2 more
doaj   +1 more source

Current and Emerging Therapeutic Approaches for Extracranial Malignant Rhabdoid Tumors

Cancer Management and Research, 2022
Karolina Nemes,1 Pascal D Johann,1,2 Stefanie Tüchert,3 Patrick Melchior,4 Christian Vokuhl,5 Reiner Siebert,6 Rhoikos Furtwängler,7 Michael C Frühwald1 1Paediatrics and Adolescent Medicine, Swabian Children’s Cancer Center, University Medical Center ...
Nemes K, Johann PD, Tüchert S, Melchior P, Vokuhl C, Siebert R, Furtwängler R, Frühwald MC   +7 more
doaj  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Antenna Array-Aided Real-Time Kinematic Using Moving Base Stations

IEEE Access, 2022
A global navigation satellite systems (GNSS) real-time kinematic (RTK) using multiple base stations is referred as an antenna array-aided RTK. This positioning method more reliably resolves carrier phase integer ambiguities by processing additional ...
Euiho Kim, Sae-Kyeol Kim
doaj   +1 more source

The transition model of RTK activation: A quantitative framework for understanding RTK signaling and RTK modulator activity

Cytokine & Growth Factor Reviews, 2019
Here, we discuss the transition model of receptor tyrosine kinase (RTK) activation, which is derived from biophysical investigations of RTK interactions and signaling. The model postulates that (1) RTKs can interact laterally to form dimers even in the absence of ligand, (2) different unliganded RTK dimers have different stabilities, (3) ligand binding
Michael D, Paul, Kalina, Hristova
openaire   +3 more sources