Increased Extracellular ATP: An Omen of Bacterial RTX Toxin-Induced Hemolysis? [PDF]
Toxins, 2014 Bacterial infection is a major threat to human health. Although pathogenic bacteria vary in their virulence, it has been recognized that many pathogenic bacteria share common mechanisms when attacking host cells and tissues.
Yifei Wang, Shijun Wang
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MALDI-TOF MS Biomarker Detection Models to Distinguish RTX Toxin Phenotypes of Moraxella bovoculi Strains Are Enhanced Using Calcium Chloride Supplemented Agar [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Moraxella bovoculi is the bacterium most often cultured from ocular lesions of cattle with infectious bovine keratoconjunctivitis, also known as bovine pinkeye. Some strains of M.
Matthew M. Hille +4 more
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Toxins, 2020 RTX-Toxins (Repeats in ToXin) are members of a rapidly expanding family of proteins [...]
Roland Benz
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Virulence factor rtx in
BMC Genomics, 2008 Background The repeats in toxin (Rtx) are an important pathogenicity factor involved in host cells invasion of Legionella pneumophila and other pathogenic bacteria. Its role in escaping the host immune system and cytotoxic activity is well known.
Pelaz Carmen +5 more
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Rapid Purification of Endotoxin-Free RTX Toxins [PDF]
Toxins, 2019 Cytolytic leukotoxins of the repeat in toxin (RTX) family are large proteins excreted by gram-negative bacterial pathogens through the type 1 secretion system (T1SS).
Ondrej Stanek +5 more
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Environmental and Regulatory Control of RTX Toxins in Gram-Negative Pathogens [PDF]
ToxinsRepeat-in-toxin (RTX) toxins are calcium-dependent exoproteins secreted by diverse Gram-negative bacteria and play central roles in cytotoxicity, immune modulation, and tissue colonization.
Hossein Jamali +2 more
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Kingella kingae RtxA Cytotoxin in the Context of Other RTX Toxins [PDF]
Microorganisms, 2022 The Gram-negative bacterium Kingella kingae is part of the commensal oropharyngeal flora of young children. As detection methods have improved, K. kingae has been increasingly recognized as an emerging invasive pathogen that frequently causes skeletal ...
Katerina Filipi +3 more
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Disorder-to-Order Transition in the CyaA Toxin RTX Domain: Implications for Toxin Secretion [PDF]
Toxins, 2014 The past decade has seen a fundamental reappraisal of the protein structure-to-function paradigm because it became evident that a significant fraction of polypeptides are lacking ordered structures under physiological conditions.
Ana-Cristina Sotomayor-Pérez +2 more
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Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins [PDF]
Toxins, 2018 Permeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis.
Asier Etxaniz +3 more
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Generation of a recombinant Aggregatibacter actinomycetemcomitans RTX toxin in Escherichia coli. [PDF]
Gene, 2018 A leukotoxin (LtxA) that is produced by Aggregatibacter actinomycetemcomitans (Aa) is an important virulence determinant in an aggressive form of periodontitis in adolescents. Understanding the function of this protein at the molecular level is critical to elucidating its role in the disease process.
Balashova N +7 more
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