Results 91 to 100 of about 8,609 (220)
Eel immune response to Vibrio vulnificus infection. Host-pathogen relationship [PDF]
, 2013 The European eel (Anguilla anguilla), has experienced a dangerous decline in recruitment, yield and stock over the last 30 years and this decline is likely to continue into the future.
Amaro González, Carmen +3 more
core +2 more sources
Molecular Crowding Effects on the CyaA Toxin RTX Domain: Implication for Toxin Secretion
The FASEB Journal, 2015 Ligand‐induced disorder‐to‐order transition plays a key role in the biological functions of many proteins that contain intrinsically disordered domains. Here, we present data on an RTX (« Repeat in ToXin ») protein, RC L , an intrinsically disordered protein (IDP) that folds upon calcium ...
Alexandre Chenal +4 more
openaire +1 more source
A Unique Mechanism of Cholesterol Binding by an RTX Toxin [PDF]
Biophysical Journal, 2013 The leukotoxin (LtxA) secreted by Aggregatibacter actinomycetemcomitans is a member of the repeats-in-toxin (RTX) family, and like the other members of the family, is a virulence protein that destroys host cells. LtxA specifically kills human white blood cells, allowing A. actinomycetemcomitans to survive within the host. LtxA has been shown to bind to
Brown, Angela C. +2 more
openaire +1 more source
Journal of Forensic Sciences, EarlyView.Abstract The rising rate of drug‐related deaths in the United States, largely driven by fentanyl, requires timely and accurate surveillance. However, critical overdose data are often buried in free‐text coroner reports, leading to delays and information loss when coded into ICD (International Classification of Disease)‐10 classifications.
Arthur J. Funnell +8 more
wiley +1 more source
L‐VISP: LSTM Visualization for Interpretable Symptom Prediction in Patient Cohorts
Computer Graphics Forum, EarlyView.L‐VISP is a human‐machine solution that uses visual analytics for LSTM modelling in clinical research. L‐VISP uses custom visual encodings to make multiple LSTM variants interpretable, supporting a full range of analysis, from understanding model operations and evaluating performance to interpreting results in a clinical context.
C. Floricel +6 more
wiley +1 more source
Translocation of Non-Canonical Polypeptides into Cells Using Protective Antigen [PDF]
, 2014 A variety of pathogenic bacteria infect host eukaryotic cells using protein toxins, which enter the cytosol and exert their cytotoxic effects. Anthrax lethal toxin, for example, utilizes the membrane-spanning translocase, protective antigen (PA) pore, to
Akcay, Gizem +3 more
core +1 more source
Autoprocessing of the Vibrio cholerae RTX toxin by the cysteine protease domain [PDF]
The EMBO Journal, 2007 Vibrio cholerae RTX is a large multifunctional bacterial toxin that causes actin crosslinking. Due to its size, it was predicted to undergo proteolytic cleavage during translocation into host cells to deliver activity domains to the cytosol. In this study, we identified a domain within the RTX toxin that is conserved in large clostridial glucosylating ...
Kerri-Lynn, Sheahan +2 more
openaire +2 more sources
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Background and Objectives While brentuximab vedotin (BV) and radiotherapy (RTx) are established treatment options for CD30‐positive cutaneous T‐cell lymphoma (CTCL), data on their simultaneous or sequential use regarding efficacy and tolerability remain scarce.
Patrick Schummer +10 more
wiley +1 more source
Journal of Periodontal Research, EarlyView.This review describes the features of grade C molar‐incisor pattern periodontitis and discusses the role of A. actinomycetemcomitans in its pathogenesis and why molars and incisors are preferably affected. Possible future studies on this aggressive disease in primary and permanent dentition and emerging omics techniques for diagnosis and management are
Luigi Nibali +3 more
wiley +1 more source
Modulation of the epithelial sodium channel (ENaC) by bacterial metalloproteases and protease inhibitors [PDF]
, 2014 The serralysin family of metalloproteases is associated with the virulence of multiple gram-negative human pathogens, including Pseudomonas aeruginosa and Serratia marcescens.
Butterworth, MB +4 more
core +7 more sources