Results 111 to 120 of about 8,609 (220)

Aggregatibacter actinomycetemcomitans Leukotoxin: A Powerful Tool with Capacity to Cause Imbalance in the Host Inflammatory Response

Toxins, 2011
Aggregatibacter actinomycetemcomitans has been described as a member of the indigenous oral microbiota of humans, and is involved in the pathology of periodontitis and various non-oral infections. This bacterium selectively kills human leukocytes through
Anders Johansson
doaj   +3 more sources

Acquisition, co-option, and duplication of the rtx toxin system and the emergence of virulence in Kingella. [PDF]

Nat Commun, 2023
Morreale DP, Porsch EA, Kern BK, St Geme JW, Planet PJ.   +4 more
europepmc   +1 more source

Molecular basis for heat desensitization of TRPV1 ion channels. [PDF]

, 2019
The transient receptor potential vanilloid 1 (TRPV1) ion channel is a prototypical molecular sensor for noxious heat in mammals. Its role in sustained heat response remains poorly understood, because rapid heat-induced desensitization (Dh) follows ...
Kamau, Peter Muiruri, Lai, Ren, Li, Bowen, Luo, Lei, Wang, Yunfei, Xu, Lizhen, Yang, Fan, Yang, Shilong, Zheng, Jie   +8 more
core   +2 more sources

Proteomic Characterization of the Oral Pathogen Filifactor alocis Reveals Key Inter-Protein Interactions of Its RTX Toxin: FtxA. [PDF]

Pathogens, 2022
Bao K, Claesson R, Gehrig P, Grossmann J, Oscarsson J, Belibasakis GN.   +5 more
europepmc   +1 more source

Analysis of Vibrio cholerae Genome Sequences Reveals Unique rtxA Variants in Environmental Strains and an rtxA-Null Mutation in Recent Altered El Tor Isolates

mBio, 2013
Vibrio cholerae genome sequences were analyzed for variation in the rtxA gene that encodes the multifunctional autoprocessing RTX (MARTX) toxin. To accommodate genomic analysis, a discrepancy in the annotated rtxA start site was resolved experimentally ...
Jazel Dolores, Karla J. F. Satchell
doaj   +1 more source

Aggregatibacter actinomycetemcomitans Leukotoxin (LtxA; Leukothera^®): Mechanisms of Action and Therapeutic Applications

Toxins, 2019
Aggregatibacter actinomycetemcomitans is an oral pathogen that produces the RTX toxin, leukotoxin (LtxA; Leukothera®). A. actinomycetemcomitans is strongly associated with the development of localized aggressive periodontitis.
Brian A. Vega, Benjamin A. Belinka Jr., Scott C. Kachlany   +2 more
doaj   +1 more source

Mecanismo de ação da toxina alfa-hemolisina de Escherichia coli [PDF]

, 2013
Escherichia coli es una de las bacterias anaerobias facultativas más predominantes en el intestino, siendo, en la mayoría de los casos, inocua para el huésped. Existen cepas que traslocan al torrente sanguíneo causando enfermedades extraintestinales como
Bakas, Laura Susana, Herlax, Vanesa Silvana, Maté, Sabina María, Vazquez, Romina Florencia   +3 more
core   +1 more source

The role of bacteria in pine wilt disease: insights from microbiome analysis. [PDF]

, 2018
Pine Wilt Disease (PWD) has a significant impact on Eurasia pine forests. The microbiome of the nematode (the primary cause of the disease), its insect vector, and the host tree may be relevant for the disease mechanism.
Alves, Marta, Correia, A, Henriques, Isabel, Henriques, J, Lopes, H, Matos, P, Mota, Manuel, Nascimento, F, Pereira, A, Vicente, Cláudia   +9 more
core   +1 more source

Molecular aspects of Bordetella pertussis pathogenesis [PDF]

, 2010
The molecular mechanisms of Bordetella virulence are now well understood, and many virulence factors have been identified and characterized at the molecular level.
Camille Locht
core   +2 more sources

ACD-crosslinked actin oligomers are potent toxins inhibiting formin-mediated actin polymerization [PDF]

, 2016
Biological Sciences: 1st Place (The Ohio State University Edward F. Hayes Graduate Research Forum)Bacterial toxins are the deadliest compounds on the planet; a single copy of a toxin is capable of compromising a host cell.
Heisler, David B.
core   +1 more source