Results 11 to 20 of about 8,609 (220)
The wild boar (
BMC Veterinary Research, 2007 Background The most predominant beta2-integrin lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18, alphaLbeta2), expressed on all leukocytes, is essential for many adhesive functions of the immune system.
Bergh Philippe +3 more
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Structure–Function Relationships of the Repeat Domains of RTX Toxins [PDF]
Toxins, 2019 RTX proteins are a large family of polypeptides of mainly Gram-negative origin that are secreted into the extracellular medium by a type I secretion system featuring a non-cleavable C-terminal secretion signal, which is preceded by a variable number of ...
Ulrich Baumann
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Intranasal application of a bifunctional pertactin-RTX fusion antigen elicits protection of mouse airway mucosa against Bordetella pertussis colonization [PDF]
mSphereThe adenylate cyclase toxin (ACT, AC-Hly, or CyaA) plays a key role in airway infections by Bordetella pertussis and ablates the oxidative burst and opsonophagocytic capacity of sentinel phagocytes.
Carlos Espinosa-Vinals +6 more
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Genomic characteristics, antimicrobial resistance profiles and virulence factors of Gallibacterium anatis isolates from layer chickens in Northern China [PDF]
BMC MicrobiologyBackground Gallibacterium anatis is an emerging pathogen causing substantial economic losses in global poultry production. Despite its growing clinical significance, the genomic basis of pathogenicity and antimicrobial resistance in this species remains ...
Fangfang Guo +9 more
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RTX toxins in Pasteurellaceae [PDF]
International Journal of Medical Microbiology, 2002 RTX toxins (repeats in the structural toxin) are pore-forming protein toxins produced by a broad range of pathogenic Gram-negative bacteria. In vitro, RTX toxins mostly exhibit a cytotoxic and often also a hemolytic activity. They are particularly widespread in species of the family Pasteurellaceae which cause infectious diseases, most frequently in ...
Frey, Joachim, Kuhnert, Peter
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Nature Communications, 2022 The authors use optical tweezers to show that the folding of repeats-in-toxin (RTX) block-iv in adenylate cyclase is templated by the folded RTX block-v. The findings suggest a possible mechanism for transmitting the folding signal in the RTX domain.
Han Wang, Guojun Chen, Hongbin Li
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Association of RTX toxins with erythrocytes [PDF]
Infection and Immunity, 1996 A critical step in the target cell attack by RTX cytotoxins is their association with target cells. A binding assay was used to study the association of the Escherichia coli hemolysin protein (HlyA) with erythrocytes. Several parameters required for lysis by HlyA were tested for their effects on its initial association with erythrocytes.
M E, Bauer, R A, Welch
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RTX Toxins Ambush Immunity’s First Cellular Responders [PDF]
Toxins, 2019 The repeats-in-toxin (RTX) family represents a unique class of bacterial exoproteins. The first family members described were toxins from Gram-negative bacterial pathogens; however, additional members included exoproteins with diverse functions. Our review focuses on well-characterized RTX family toxins from Aggregatibacter actinomycetemcomitans (LtxA),
Laura C. Ristow, Rodney A. Welch
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PLoS Pathogens, 2021 RTX leukotoxins are a diverse family of prokaryotic virulence factors that are secreted by the type 1 secretion system (T1SS) and target leukocytes to subvert host defenses. T1SS substrates all contain a C-terminal RTX domain that mediates recruitment to
Jory A Goldsmith +3 more
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Calcium-induced folding of intrinsically disordered RTX proteins: Implications for RTX toxin physiology [PDF]
Toxicon, 2013 The past decade has seen a fundamental reappraisal of the protein structure-to-function paradigm because it became evident that a significant fraction of polypeptides are lacking ordered structures under physiological conditions. Ligand-induced disorder-to-order transition plays a key role in the biological functions of many proteins that contain ...
Sotomayor Perez, Ana Cristina +2 more
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