Results 21 to 30 of about 8,609 (220)
Cells, 2023 Resiniferatoxin (RTX) is a potent capsaicin analog used as a drug for experimental therapy to treat neurogenic disorders associated with enhanced nociceptive transmission, including lower urinary tract symptoms.
Ewa Lepiarczyk +6 more
doaj +1 more source
Frontiers in Microbiology, 2022 Type 1 secretion systems play important roles in pathogenicity of Gram-negative bacteria. However, the substrate secretion mechanism remains largely unknown.
Zewei Chen +8 more
doaj +1 more source
A Non-Covalent Antibody Complex for the Delivery of anti-cancer drugs [PDF]
, 2019 Antibody drug conjugates (ADCs), which are obtained by coupling a potent cytotoxic agent to a monoclonal antibody (mAb), are traditionally bound in a random way to lysine or cysteine residues, with the final product's heterogeneity having an important ...
Grigoletto, Antonella +5 more
core +1 more source
New Insights into the Type II Toxins from the Sea Anemone Heteractis crispa
Toxins, 2020 Toxins modulating NaV channels are the most abundant and studied peptide components of sea anemone venom. Three type-II toxins, δ-SHTX-Hcr1f (= RpII), RTX-III, and RTX-VI, were isolated from the sea anemone Heteractis crispa.
Rimma S. Kalina +10 more
doaj +1 more source
Structure of the full-length TRPV2 channel by cryo-EM. [PDF]
, 2016 Transient receptor potential (TRP) proteins form a superfamily Ca(2+)-permeable cation channels regulated by a range of chemical and physical stimuli. Structural analysis of a 'minimal' TRP vanilloid subtype 1 (TRPV1) elucidated a mechanism of channel ...
Cohen, Matthew R +6 more
core +2 more sources
Growth Phase Regulation of Vibrio cholerae RTX Toxin Export [PDF]
Journal of Bacteriology, 2007 ABSTRACT Vibrio cholerae , the causative agent of the severe diarrheal disease cholera, secretes several “accessory” toxins, including RTX toxin, which causes the cross-linking of the actin cytoskeleton. RTX toxin is exported to the extracellular milieu by an atypical type I secretion system (T1SS), and we previously ...
Bethany Kay, Boardman +2 more
openaire +2 more sources
Gastroenterology Research and Practice, 2017 Clostridium difficile toxin A is a colonic inflammatory agent that acts partially by activation of TRPV1 (transient receptor potential vanilloid type 1).
Steven R. Vigna
doaj +1 more source
Membrane Permeabilization by Pore-Forming RTX Toxins: What Kind of Lesions Do These Toxins Form?
Toxins, 2019 Pore-forming toxins (PFTs) form nanoscale pores across target membranes causing cell death. The pore-forming cytolysins of the RTX (repeats in toxin) family belong to a steadily increasing family of proteins characterized by having in their primary ...
Helena Ostolaza +5 more
doaj +1 more source
Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes [PDF]
, 2017 Adenylate cyclase toxin (ACT) is one of the principal virulence factors secreted by the whooping cough causative bacterium Bordetella pertussis, and it has a critical role in colonization of the respiratory tract and establishment of the disease.
Belloso Uribe, Kepa +4 more
core +3 more sources
Detection of RTX Toxin Gene in Vibrio cholerae by PCR [PDF]
Journal of Clinical Microbiology, 2001 ABSTRACT A PCR that amplifies a recently discovered Vibrio cholerae RTX (repeat in toxin) toxin gene was developed. Among 166 clinical and environmental isolates of V. cholerae causing epidemics and sporadic cases of cholera in various parts of the world, all were found to be ...
Chow, KH, Yam, WC, Yuen, KY, Ng, TK
openaire +4 more sources