Results 51 to 60 of about 8,609 (220)
Scientific Reports, 2022 Many proteins of the Repeats in Toxins (RTX) protein family are toxins of Gram-negative pathogens including hemolysin A (HlyA) of uropathogenic E. coli. RTX proteins are secreted via Type I secretion systems (T1SS) and adopt their native conformation in ...
Isabelle N. Erenburg +13 more
doaj +1 more source
Comparative Genome Analyses of Vibrio anguillarum Strains Reveal a Link with Pathogenicity Traits [PDF]
, 2017 Vibrio anguillarum is a marine bacterium that can cause vibriosis in many fish and shellfish species, leading to high mortalities and economic losses in aquaculture.
Daniel Castillo +6 more
core +3 more sources
The Moraxella bovis RTX toxin locus mbx defines a pathogenicity island [PDF]
Journal of Medical Microbiology, 2006 To characterize flanking regions of thembxoperon inMoraxella bovis, DNA surroundingmbxCABDtolCwas sequenced in haemolytic and nonhaemolytic strains ofM. bovis. In two haemolytic strains ofM. bovis, thembxoperon, including the adjacentM. bovis tolCorthologue, was flanked by approximately 700 bp imperfect repeats. Nonhaemolytic strains ofM. bovishad only
John F, Hess, John A, Angelos
openaire +2 more sources
Autoproteolytic Activation of Bacterial Toxins
Toxins, 2010 Protease domains within toxins typically act as the primary effector domain within target cells. By contrast, the primary function of the cysteine protease domain (CPD) in Multifunctional Autoprocessing RTX-like (MARTX) and Clostridium sp.
Aimee Shen
doaj +1 more source
Recombinant Moraxella bovoculi cytotoxin-ISCOM matrix adjuvanted vaccine to prevent naturally occurring infectious bovine keratoconjunctivitis [PDF]
, 2010 A randomized, blinded, controlled field trial was conducted during summer 2006 in a northern California, USA, herd of beef cattle to evaluate the efficacy of a recombinant Moraxella bovoculi cytotoxin subunit vaccine to prevent naturally occurring ...
John A. Angelos +3 more
core +2 more sources
Engineering New‐to‐Nature Biological Pathways for β,γ‐Alkanediol Synthesis
Advanced Science, EarlyView.β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Haofeng Chen +6 more
wiley +1 more source
Molecular Characterization of Protease Activity in Serratia sp. Strain SCBI and Its Importance in Cytotoxicity and Virulence [PDF]
, 2014 A newly recognized Serratia species, termed South African Caenorhabditis briggsae isolate (SCBI), is both a mutualist of the nematode Caenorhabditis briggsae KT0001 and a pathogen of lepidopteran insects. Serratia sp.
Petersen, Lauren M., Tisa, Louis S.
core +2 more sources
Bacterial RTX Toxins Allow Acute ATP Release from Human Erythrocytes Directly through the Toxin Pore [PDF]
Journal of Biological Chemistry, 2014 ATP is as an extracellular signaling molecule able to amplify the cell lysis inflicted by certain bacterial toxins including the two RTX toxins α-hemolysin (HlyA) from Escherichia coli and leukotoxin A (LtxA) from Aggregatibacter actinomycetemcomitans.
Skals, Marianne +7 more
openaire +3 more sources
Advanced Science, EarlyView.The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob +12 more
wiley +1 more source
Toxins, 2017 The Bordetella pertussis CyaA-hemolysin (CyaA-Hly) domain was previously demonstrated to be an important determinant for hemolysis against target erythrocytes and ion-channel formation in planar lipid bilayers (PLBs).
Chattip Kurehong +5 more
doaj +1 more source