Results 51 to 60 of about 6,658 (202)

Pharmacogenomics in Cancer Treatment: Challenges and Opportunities in African Settings

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background Cancer incidence in Africa is projected to reach 2.1 million new cases annually by 2040. Current treatment guidelines remain largely based on pharmacogenomic data predominantly from European and Asian genetic profiles, potentially compromising safety and efficacy in African patients.
Ntombikhona Fortunate Maphumulo, George Rebello, Veron Ramsuran   +2 more
wiley   +1 more source

Decreased clonogenic survival of PCa cells exposed to radiation and rucaparib.

, 2013
A, Radiation and rucaparib dose response in PC3, C4-2, DU145, VCaP and LNCaP cells was established by clonogenic cell survival assays. Left panels indicate the response to radiation, those on the right to rucaparib.
Payel Chatterjee (397793), Arishya Sharma (397795), Gaurav S. Choudhary (397794), Kamini Singh (32638), Warren D. Heston (397796), Jay Ciezki (397797), Alexandru Almasan (3962), Eric A. Klein (138229)   +7 more
core   +1 more source

Efficacy and safety of rucaparib in patients with recurrent high-grade ovarian carcinoma: A systematic review and meta-analysis

Taiwanese Journal of Obstetrics & Gynecology
Ovarian cancer stands as the third most prevalent gynecological malignancy. The advent of PARP inhibitors, particularly rucaparib, has revolutionized the landscape of advanced ovarian cancer treatment, demonstrating notable efficacy with minimal toxicity,
Nicholas Adrianto, Ghea Mangkuliguna, Eunike Jennifer Tandiono, Candra Novi Ricardo Sibarani   +3 more
doaj   +1 more source

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Pre-clinical imaging evaluation of the PARP inhibitor rucaparib [PDF]

, 2013
PhD ThesisPoly(ADP-ribose) polymerase 1 (PARP1) is a DNA-binding enzyme involved in DNA repair by the base-excision pathway. The inhibition of PARP1 is being investigated as a cancer treatment.
Almeida, Gilberto Serrano de
core  

Repurposing and computational design of PARP inhibitors as SARS-CoV-2 inhibitors

Scientific Reports, 2023
Coronavirus disease 2019 (COVID-19) is a recent pandemic that caused serious global emergency. To identify new and effective therapeutics, we employed a drug repurposing approach. The poly (ADP ribose) polymerase inhibitors were used for this purpose and
Shailima Rampogu, Tae Sung Jung, Min Woo Ha, Keun Woo Lee   +3 more
doaj   +1 more source

Next‐Generation Sequencing‐Based Molecular Profiling and Management of Advanced Solid Tumors: A Real‐World Experience in a Community‐Based Academic Cancer Center

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Advances in molecular and cell biology have led to a paradigm shift in cancer management. We implemented next‐generation sequencing (NGS) at our community‐based academic cancer center over a decade ago. We sought to optimize the use of genomics and understand its impact in identifying actionable genomic alterations to determine ...
Gayathri Moorthy, Annette Sereika, Karen Kaul, Megan Parilla, Mir B. Alikhan, Michael Bouma, Dyson Wake, Peter J. Hulick, Henry M. Dunnenberger, Linda M. Sabatini, Mathew Yang, Kathy A. Mangold, Erin Proctor, Nicholas Evans, Nicholas Miller, Donald L. Helseth Jr, Darryck Maurer, Justin Brueck, Janardan Khandekar, Bruce Brockstein   +19 more
wiley   +1 more source

Attenuation of Muscle Damage, Structural Abnormalities, and Physical Activity in Respiratory and Limb Muscles following Treatment with Rucaparib in Lung Cancer Cachexia Mice

, 2022
SIMPLE SUMMARY: Muscle wasting and cachexia are common in patients with cancer. Several mechanisms underlie muscle physiological and structural alterations in cancer-induced cachexia. Poly (ADPribose) polymerases (PARPs) are involved in muscle metabolism
Barreiro, Esther, Maria Pérez-Peiró, Pérez-Peiró, Maria, Yélamos, José, José Yélamos, Esther Barreiro, Xavier Duran, Duran, Xavier, Barreiro Portela, Esther, Yélamos López, José, Duran Jordà, Xavier, 1974-   +10 more
core   +1 more source

Pharmacokinetic Study of Rucaparib in Patients With Advanced Solid Tumors [PDF]

, 2018
The phase 1‐2 study CO‐338‐010 (Study 10; NCT01482715) is evaluating single‐agent rucaparib, a poly(ADP‐ribose) polymerase inhibitor, administered orally to patients with an advanced solid tumor.
Heidi Giordano, Sandra Goble, Manish R. Patel, Patel, MR, Giordano, H, Watkins, S, Patricia LoRusso, LoRusso, P, Shapiro, GI, Goble, S, Jaw-Tsai, S, Kristeleit, RS, Burris, HA, Sarah Jaw-Tsai, Drew, Y, Simon Watkins, Jim J. Xiao, Yvette Drew, Lara Maloney, Howard A. Burris, Rebecca S. Kristeleit, Geoffrey I. Shapiro, Maloney, L, Xiao, JJ   +23 more
core   +2 more sources