Results 41 to 50 of about 19,567 (259)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

CALM: Cultivating Awareness, Learning, and Mastery to Reduce Anger and Violence Through Combat Sports

Youth
Youth violence is a pressing social issue. Many well-informed interventions to reduce youth violence fail due to low uptake. Combat sports—such as boxing, judo, and mixed martial arts—appear to encourage aggression, making them appealing to individuals ...
Andrew M. Lane
doaj   +1 more source

RULE‐GOVERNED BEHAVIOR AND SENSITIVITY TO CHANGING CONSEQUENCES OF RESPONDING [PDF]

Journal of the Experimental Analysis of Behavior, 1986
Humans were presented with a task that required moving a light through a matrix. Button presses could produce light movements according to a multiple fixed‐ratio 18/differential‐reinforcement‐of‐low‐rate 6‐s schedule, with components alternating every 2 min. Moving the light through the maze earned points worth chances on money prizes.
S C, Hayes, A J, Brownstein, R D, Zettle, I, Rosenfarb, Z, Korn   +4 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

REPEATED ACQUISITION IN THE ANALYSIS OF RULE‐GOVERNED BEHAVIOR [PDF]

Journal of the Experimental Analysis of Behavior, 1985
Five children, ranging in age from 3½ years to 5½ years, were taught various four‐response chains using conditioned reinforcement. Experiment 1 investigated the effects of presenting “instruction” stimuli — a sequence of lights over the correct response buttons — to assess their role in facilitating the acquisition of a chain of responses. Without the “
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Análise do papel de variáveis sociais e de conseqüências programadas no seguimento de instruções Analyzing the role of social variables and programmed consequences in instruction-following

Psicologia: Reflexão e Crítica, 2004
Investigando o papel da monitorização no seguimento de instruções, 12 crianças foram expostas a um procedimento de escolha segundo o modelo. A tarefa era tocar um dos dois estímulos de comparação na presença de um estímulo contextual.
Niele Márcia Amaral de Albuquerque, Carla Cristina Paiva Paracampo, Luiz Carlos de Albuquerque   +2 more
doaj   +1 more source