Results 71 to 80 of about 19,567 (259)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Voices in Bioethics, 2014 Global colorism is seldom discussed in the field of bioethics, but it affects almost every facet of medical practice. The ethical challenge of colorism has global implications that are psychologically, physiologically, sociologically, and medically ...
Obiora Anekwe
doaj +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Oil & Gas Science and Technology, 2006 L'évaluation comparative du comportement en solution des polylmides 6F fait ressortir que ces nouveaux polymères, doués d'une stabilité thermique élevée par référence à l'analyse thermogravimétrique, ont, par contraste, une résistance beaucoup plus ...
Mileo J. C.
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Bifurcation of drift wave turbulence trapping by zonal flows near density limit
Nuclear FusionWe investigate drift wave—zonal flow interactions near the density limit and demonstrate transitions of turbulence trapping states. Nonlinear simulations of the modified Hasegawa–Wakatani model reveal two robust types of turbulence energy localization ...
M. Sasaki +6 more
doaj +1 more source
BuildingsIn traditional Chinese timber architecture, “column reduction” (Jian Zhu Zao) and “column relocation” (Yi Zhu Zao) enhances spatial continuity, yet often produces bending-dominated, material-intensive frames. This study develops a generative frame system
Tonghao Liu, Binyue Zhang, Yamin Zhao
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Theoretical Approaches to the Concept of Legal Relations
СибСкриптA state governed by the rule of law establishes balanced legal relations. This article describes four scientific and theoretical approaches to the concept of legal relations, i.e., legal, subject-object, moral, and socio-psychological.
Dmitrii S. Beznosov
doaj +1 more source