Results 61 to 70 of about 286,800 (345)

Development of intake manifold for Student Formula CMU F-914 using theoretical and simulated designs [PDF]

open access: yesResearch & Knowledge, 2015
The objectives of this study were to design, develop and construct an intake manifold for the Student Formula CMU F-914 race car, or the F-914, by using theoretical analysis together with simulation software and experimental verifi cation of the design ...
Niti Kammuang-lue, Worawit Borikhut
doaj  

Fate of the runner in hit-and-run collisions [PDF]

open access: yes, 2019
In similar-sized planetary collisions, a significant part of the impactor often misses the target and continues downrange. We follow the dynamical evolution of "runners" from giant impacts to determine their ultimate fate. Surprisingly, runners re-impact
Asphaug, Erik, Emsenhuber, Alexandre
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Determination and generalization of the effects of design parameters on Francis turbine runner performance

open access: yesEngineering Applications of Computational Fluid Mechanics, 2016
The runner design is the most challenging part of the turbine design process. Several parameters determine the performance and cavitation characteristics of the runner: the metal angle (flow beta angle), the alpha angle, the blade beta angle, the runner ...
Ece Ayli, Kutay Celebioglu, Selin Aradag
doaj   +1 more source

Overview of the experimental tests in prototype [PDF]

open access: yes, 2017
Experimental tests in prototype are necessary to understand the dynamic behaviour of the machine during different operating points. Hydraulic phenomena as well as its effect on the structure need to be studied in o rder to avoid instabilities during ...
Egusquiza Estévez, Eduard   +3 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Do not be Afraid of Small High-Speed Francis Turbines

open access: yesJournal of Mechanical Engineering, 2018
In the first quarter of the last century hydraulic power plants were equipped with high-speed Francis turbines even in the situation when a contemporary project manager would suggest Kaplan turbine. The reason is simple. Mr.
Libor Koudelka
doaj   +1 more source

"The German language and literature special collections at the University library of Frankfurt am Main and the work of the subject specialist" : paper delivered in Göttingen, 4. 9. 2007, at the annual conference of the German Studies Library Group (GSLG) [PDF]

open access: yes, 2007
Contents - BIX: pole position and runner-up - Frankfurt University Library: its responsibilities, its collections, its databases, its supra-regional collecting responsibilities – and some statistics - The "Sondersammelgebiet" Germanistik: its scope and ...
Giesen, Winfried
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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