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Runs of homozygosity: windows into population history and trait architecture
Nature Reviews Genetics, 2018 Long runs of homozygosity (ROH) arise when identical haplotypes are inherited from each parent and thus a long tract of genotypes is homozygous. Cousin marriage or inbreeding gives rise to such autozygosity; however, genome-wide data reveal that ROH are universally common in human genomes even among outbred individuals.
Francisco C Ceballos +2 more
exaly +5 more sources
Long Runs of Homozygosity Are Enriched for Deleterious Variation [PDF]
American Journal of Human Genetics, 2013 Exome sequencing offers the potential to study the population-genomic variables that underlie patterns of deleterious variation. Runs of homozygosity (ROH) are long stretches of consecutive homozygous genotypes probably reflecting segments shared identically by descent as the result of processes such as consanguinity, population size reduction, and ...
Zachary A Szpiech +2 more
exaly +3 more sources
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Runs of homozygosity: current knowledge and applications in livestock
Animal Genetics, 2016SummaryThis review presents a broader approach to the implementation and study of runs of homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH and their practical implications. ROH are continuous homozygous segments that are common in individuals and populations.
E, Peripolli +5 more
openaire +2 more sources
No evidence for excess runs of homozygosity in bipolar disorder
Psychiatric Genetics, 2009Recent studies have reported large common regions of homozygosity (ROHs) that are the result of autozygosity, that is, the cooccurrence within individuals of long haplotypes that have a high frequency in the population. A recent study reports that such regions are found more commonly in individuals with schizophrenia compared with controls, and ...
Anna E, Vine +10 more
openaire +2 more sources
Runs of homozygosity reveal genome‐wide autozygosity in Italian sheep breeds
Animal Genetics, 2018SummaryThe availability of dense single nucleotide polymorphism (SNP) assays allows for the determination of autozygous segments based on runs of consecutive homozygous genotypes (ROH). The aim of the present study was to investigate the occurrence and distribution of ROH in 21 Italian sheep breeds using medium‐density SNP genotypes in order to ...
Mastrangelo, S. +5 more
openaire +3 more sources
Vizualizacija "Runs of Homozygosity" DNA segmenata [PDF]
, 2018 "Runs of homozygosity" are segments or whole genomic regions where the identical haplotypes are inherited from each parent. Since their discovery because of the technological advances in late 90s, "Runs of homozygosity" shed some light on about individual genome origin, decoding the genetic base of monogenic and complex traits and diseases.
openaire
Parental relatedness through time revealed by runs of homozygosity in ancient DNA
Nature Communications, 2021Harald Ringbauer, John Novembre
exaly
Open data from the first and second observing runs of Advanced LIGO and Advanced Virgo
SoftwareX, 2021Riccardo Bassiri +2 more
exaly