Results 1 to 10 of about 1,564 (152)
Approaching autozygosity in a small pedigree of Gochu Asturcelta pigs [PDF]
Genetics Selection Evolution, 2023 Background In spite of the availability of single nucleotide polymorphism (SNP) array data, differentiation between observed homozygosity and that caused by mating between relatives (autozygosity) introduces major difficulties.
Katherine D. Arias +4 more
doaj +5 more sources
Influence of autozygosity on common disease risk across the phenotypic spectrum [PDF]
Cell, 2023 Autozygosity is associated with rare Mendelian disorders and clinically relevant quantitative traits. We investigated associations between the fraction of the genome in runs of homozygosity (FROH) and common diseases in Genes & Health (n = 23,978 British South Asians), UK Biobank (n = 397,184), and 23andMe.
Chris Griffiths +2 more
exaly +9 more sources
Evolution of Methods for the Quantitative Assessment of Inbreeding in Livestock [PDF]
BiologyInbreeding is a quantitative measure of autozygosity that underlies the assessment of genetic risks and the management of genetic progress in livestock populations.
Lyubov Getmantseva +5 more
doaj +2 more sources
Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish [PDF]
BMC Genomics, 2023 Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity
Megan T. Lynch +6 more
doaj +2 more sources
Comparing Genomic and Pedigree Inbreeding Coefficients in the Slovenian Lipizzan Horse as a Case Study for Small Closed Populations [PDF]
AnimalsIn small, closed populations such as the Lipizzan horse, maintaining genetic diversity while limiting inbreeding is a key challenge in conservation breeding.
Barbara Luštrek +4 more
doaj +2 more sources
Frontiers in Genetics, 2021 Prior work in late-onset Alzheimer’s disease (LOAD) has resulted in discrepant findings as to whether recent consanguinity and outbred autozygosity are associated with LOAD risk.
Valerio Napolioni +2 more
exaly +3 more sources
Frontiers in Genetics, 2019 Genomic information from crossbreds is routinely generated for genomic evaluations. The objective of this study is to investigate autozygosity and genetic differentiation in Landrace by Large-White breeds by using the genotypic information of SNP arrays ...
Wendy Mercedes Rauw +2 more
exaly +3 more sources
Frontiers in Genetics, 2022 Pikeperch (Sander lucioperca) has emerged as a high value species to the aquaculture industry. However, its farming techniques are at an early stage and its production is often performed without a selective breeding program, potentially leading to high ...
Lidia De Los Rios Perez +2 more
exaly +3 more sources
AnimalCrossbreeding might be a valid strategy to valorize local pig breeds. Crossbreeding should reduce homozygosity and, as a consequence, yield hybrid vigor for fitness and production traits.
Luca Fontanesi +2 more
exaly +3 more sources
Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts [PDF]
American Journal of Human Genetics, 2023 Matthew C Keller +2 more
exaly +2 more sources