Results 1 to 10 of about 1,491 (109)

Evolution of Methods for the Quantitative Assessment of Inbreeding in Livestock [PDF]

Biology
Inbreeding is a quantitative measure of autozygosity that underlies the assessment of genetic risks and the management of genetic progress in livestock populations.
Lyubov Getmantseva, Siroj Bakoev, Maria Kolosova, Alexandr Usatov, Kharon Amerkhanov, Olga Lukonina   +5 more
doaj   +2 more sources

Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish [PDF]

BMC Genomics, 2023
Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity
Megan T. Lynch, Kristin A. Maloney, Huichun Xu, James A. Perry, Regeneron Genetics Center, Alan R. Shuldiner, Braxton D. Mitchell   +6 more
doaj   +2 more sources

Comparing Genomic and Pedigree Inbreeding Coefficients in the Slovenian Lipizzan Horse as a Case Study for Small Closed Populations [PDF]

Animals
In small, closed populations such as the Lipizzan horse, maintaining genetic diversity while limiting inbreeding is a key challenge in conservation breeding.
Barbara Luštrek, Martin Šimon, Klemen Turk, Sanja Bogičević, Klemen Potočnik   +4 more
doaj   +2 more sources

Recent Consanguinity and Outbred Autozygosity Are Associated With Increased Risk of Late-Onset Alzheimer’s Disease

Frontiers in Genetics, 2021
Prior work in late-onset Alzheimer’s disease (LOAD) has resulted in discrepant findings as to whether recent consanguinity and outbred autozygosity are associated with LOAD risk.
Valerio Napolioni, Marzia Antonella Scelsi, Raiyan R Khan   +2 more
exaly   +3 more sources

Autozygosity and Genetic Differentiation of Landrace and Large White Pigs as Revealed by the Genetic Analyses of Crossbreds

Frontiers in Genetics, 2019
Genomic information from crossbreds is routinely generated for genomic evaluations. The objective of this study is to investigate autozygosity and genetic differentiation in Landrace by Large-White breeds by using the genotypic information of SNP arrays ...
L Gomez-Raya, Wendy M Rauw, Jack C M Dekkers   +2 more
exaly   +3 more sources

Analysis of Autozygosity Using Whole-Genome Sequence Data of Full-Sib Families in Pikeperch (Sander lucioperca)

Frontiers in Genetics, 2022
Pikeperch (Sander lucioperca) has emerged as a high value species to the aquaculture industry. However, its farming techniques are at an early stage and its production is often performed without a selective breeding program, potentially leading to high ...
Lidia De Los Ríos-Pérez, Tom Druet, Tom Goldammer   +2 more
exaly   +3 more sources

Persistence of autozygosity in crossbreds between autochthonous and cosmopolitan breeds of swine: a simulation study

Animal
Crossbreeding might be a valid strategy to valorize local pig breeds. Crossbreeding should reduce homozygosity and, as a consequence, yield hybrid vigor for fitness and production traits.
Maria Chiara Fabbri, Francesco Tiezzi, Marjeta Čandek-Potokar   +2 more
exaly   +3 more sources

Influence of autozygosity on common disease risk across the phenotypic spectrum [PDF]

Cell, 2023
Daniel Malawsky, Ahsan Khan, Masa Umićević Mirkov   +2 more
exaly   +3 more sources

Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts [PDF]

American Journal of Human Genetics, 2023
Sarah M C Colbert, Frank R Wendt, Gita A Pathak   +2 more
exaly   +2 more sources

Analysis of Homozygous-by-Descent (HBD) Segments for Purebred and Crossbred Pigs in Russia

Life, 2021
Intensive selection raises the efficiency of pig farming considerably, but it also promotes the accumulation of homozygosity, which can lead to an increase in inbreeding and the accumulation of deleterious variation.
Siroj Bakoev, Anatoly Kolosov, Faridun Bakoev, Olga Kostyunina, Nekruz Bakoev, Timofey Romanets, Olga Koshkina, Lyubov Getmantseva   +7 more
doaj   +1 more source