Results 1 to 10 of about 2,450 (151)

Persistence of autozygosity in crossbreds between autochthonous and cosmopolitan breeds of swine: a simulation study [PDF]

Animal
Crossbreeding might be a valid strategy to valorize local pig breeds. Crossbreeding should reduce homozygosity and, as a consequence, yield hybrid vigor for fitness and production traits.
Luca Fontanesi, Riccardo Bozzi, Maria Chiara Fabbri   +2 more
exaly   +4 more sources

Evolution of Methods for the Quantitative Assessment of Inbreeding in Livestock [PDF]

Biology
Inbreeding is a quantitative measure of autozygosity that underlies the assessment of genetic risks and the management of genetic progress in livestock populations.
Lyubov Getmantseva, Siroj Bakoev, Maria Kolosova, Alexandr Usatov, Kharon Amerkhanov, Olga Lukonina   +5 more
doaj   +2 more sources

Comparing Genomic and Pedigree Inbreeding Coefficients in the Slovenian Lipizzan Horse as a Case Study for Small Closed Populations [PDF]

Animals
In small, closed populations such as the Lipizzan horse, maintaining genetic diversity while limiting inbreeding is a key challenge in conservation breeding.
Barbara Luštrek, Martin Šimon, Klemen Turk, Sanja Bogičević, Klemen Potočnik   +4 more
doaj   +2 more sources

Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish

BMC Genomics, 2023
Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity
Megan T. Lynch, Kristin A. Maloney, Huichun Xu, James A. Perry, Regeneron Genetics Center, Alan R. Shuldiner, Braxton D. Mitchell   +6 more
doaj   +1 more source

Analysis of Homozygous-by-Descent (HBD) Segments for Purebred and Crossbred Pigs in Russia

Life, 2021
Intensive selection raises the efficiency of pig farming considerably, but it also promotes the accumulation of homozygosity, which can lead to an increase in inbreeding and the accumulation of deleterious variation.
Siroj Bakoev, Anatoly Kolosov, Faridun Bakoev, Olga Kostyunina, Nekruz Bakoev, Timofey Romanets, Olga Koshkina, Lyubov Getmantseva   +7 more
doaj   +1 more source

Ethiopian indigenous goats offer insights into past and recent demographic dynamics and local adaptation in sub‐Saharan African goats

Evolutionary Applications, 2021
Knowledge on how adaptive evolution and human socio‐cultural and economic interests shaped livestock genomes particularly in sub‐Saharan Africa remains limited.
Getinet M. Tarekegn, Negar Khayatzadeh, Bin Liu, Sarah Osama, Aynalem Haile, Barbara Rischkowsky, Wenguang Zhang, Kassahun Tesfaye, Tadelle Dessie, Okeyo A. Mwai, Appolinaire Djikeng, Joram M. Mwacharo   +11 more
doaj   +1 more source

Autozygosity Mapping by Genome-wide Single Nucleotide Polymorphism Array Identifies a Novel Homozygous HR Mutation in a Consanguineous Family with Universal Hereditary Hair Loss

International Journal of Dermatology and Venerology, 2021
. Objective:. Isolated hereditary hypotrichosis is caused by mutations in as many as 11 different genes. The conventional mutation detection strategy consists of sequencing of individual candidate genes separately, a time consuming and costly approach ...
Sirous Zeinali, Leila Youssefian, Hassan Vahidnezhad, Amir Hossein Saeidian, Soheila Sotoudeh, Hamideh Bagherian, Jouni Uitto   +6 more
doaj   +1 more source

The Relationship between Runs of Homozygosity and Inbreeding in Jersey Cattle under Selection. [PDF]

PLoS ONE, 2015
Inbreeding is often an inevitable outcome of strong directional artificial selection but on average it reduces population fitness with increased frequency of recessive deleterious alleles. Runs of homozygosity (ROH) representing genomic autozygosity that
Eui-Soo Kim, Tad S Sonstegard, Curtis P Van Tassell, George Wiggans, Max F Rothschild   +4 more
doaj   +1 more source

Exploiting the Autozygome to Support Previously Published Mendelian Gene-Disease Associations: An Update

Frontiers in Genetics, 2020
There is a growing interest in standardizing gene-disease associations for the purpose of facilitating the proper classification of variants in the context of Mendelian diseases.
Sateesh Maddirevula, Hanan E. Shamseldin, Amy Sirr, Lama AlAbdi, Lama AlAbdi, Russell S. Lo, Nour Ewida, Mashael Al-Qahtani, Mais Hashem, Firdous Abdulwahab, Omar Aboyousef, Namik Kaya, Dorota Monies, May H. Salem, Naffaa Al Harbi, Hesham M. Aldhalaan, Hamad Alzaidan, Hamad Alzaidan, Hadeel M. Almanea, Abrar K. Alsalamah, Fuad Al Mutairi, Samira Ismail, Ghada M. H. Abdel-Salam, Amal Alhashem, Amal Alhashem, Ali Asery, Eissa Faqeih, Amal AlQassmi, Waleed Al-Hamoudi, Talal Algoufi, Mohammad Shagrani, Mohammad Shagrani, Aimée M. Dudley, Fowzan S. Alkuraya, Fowzan S. Alkuraya   +34 more
doaj   +1 more source

Effect of artificial selection on runs of homozygosity in u.s. Holstein cattle. [PDF]

PLoS ONE, 2013
The intensive selection programs for milk made possible by mass artificial insemination increased the similarity among the genomes of North American (NA) Holsteins tremendously since the 1960s.
Eui-Soo Kim, John B Cole, Heather Huson, George R Wiggans, Curtis P Van Tassell, Brian A Crooker, George Liu, Yang Da, Tad S Sonstegard   +8 more
doaj   +1 more source