Results 41 to 50 of about 1,564 (152)

Genome-wide autozygosity is associated with lower general cognitive ability [PDF]

Molecular Psychiatry, 2015
Inbreeding depression refers to lower fitness among offspring of genetic relatives. This reduced fitness is caused by the inheritance of two identical chromosomal segments (autozygosity) across the genome, which may expose the effects of (partially) recessive deleterious mutations.
Howrigan, D P, Simonson, M A, Davies, G, Harris, S E, Tenesa, A, Starr, J M, Liewald, D C, Deary, I J, McRae, A, Wright, M J, Montgomery, G W, Hansell, N, Martin, N G, Payton, A; id_orcid 0000-0003-0335-152X, Horan, M, Ollier, W E, Abdellaoui, A, Boomsma, D I, DeRosse, P, Knowles, E E M, Glahn, D C, Djurovic, S, Melle, I, Andreassen, O A, Christoforou, A, Steen, V M, Hellard, S L, Sundet, K, Reinvang, I, Espeseth, T, Lundervold, A J, Giegling, I, Konte, B, Hartmann, A M, Rujescu, D, Roussos, P, Giakoumaki, S, Burdick, K E, Bitsios, P, Donohoe, G, Corley, R P, Visscher, P M, Pendleton, N, Malhotra, A K, Neale, B M, Lencz, T, Keller, M C   +46 more
openaire   +8 more sources

Lack of involvement of known DNA methyltransferases in familial hydatidiform mole implies the involvement of other factors in establishment of imprinting in the human female germline

BMC Genetics, 2003
Background Differential methylation of the two alleles is a hallmark of imprinted genes. Correspondingly, loss of DNA methyltransferase function results in aberrant imprinting and abnormal post-fertilization development.
Picton H M, Huntriss J, Hodge D, Judson H, De Vos M, Hayward B E, Sheridan E, Bonthron DT   +7 more
doaj   +1 more source

Locating a novel autosomal recessive genetic variant in the cattle glucokinase gene using only WGS data from three cases and six carriers

Frontiers in Genetics, 2022
New Mendelian genetic conditions, which adversely affect livestock, arise all the time. To manage them effectively, some methods need to be devised that are quick and accurate.
Geoffrey E. Pollott, Richard J. Piercy, Claire Massey, Mazdak Salavati, Mazdak Salavati, Zhangrui Cheng, D. Claire Wathes   +6 more
doaj   +1 more source

Genome-Wide Runs of Homozygosity Revealed Selection Signatures in Bos indicus

Frontiers in Genetics, 2020
Genome-wide runs of homozygosity (ROH) are suitable for understanding population history, calculating genomic inbreeding, deciphering genetic architecture of complex traits and diseases as well as identifying genes linked with agro-economic traits ...
S. P. Dixit, Sanjeev Singh, Indrajit Ganguly, Avnish Kumar Bhatia, Anurodh Sharma, N. Anand Kumar, Ajay Kumar Dang, S. Jayakumar   +7 more
doaj   +1 more source

Autozygosity mapping and time-to-spontaneous delivery in Norwegian parent-offspring trios [PDF]

Human Molecular Genetics, 2020
Abstract Parental genetic relatedness may lead to adverse health and fitness outcomes in the offspring. However, the degree to which it affects human delivery timing is unknown. We use genotype data from ≃25 000 parent-offspring trios from the Norwegian Mother, Father and Child Cohort Study to optimize runs of homozygosity (ROH ...
Pol Sole-Navais, Jonas Bacelis, Øyvind Helgeland, Dominika Modzelewska, Marc Vaudel, Christopher Flatley, Ole Andreassen, Pål R Njølstad, Louis J Muglia, Stefan Johansson, Ge Zhang, Bo Jacobsson   +11 more
openaire   +8 more sources

Comparative evaluation of genomic inbreeding parameters in seven commercial and autochthonous pig breeds

Animal, 2020
Single nucleotide polymorphism (SNP) genotyping tools, which can analyse thousands of SNPs covering the whole genome, have opened new opportunities to estimate the inbreeding level of animals directly using genome information.
G. Schiavo, S. Bovo, F. Bertolini, S. Tinarelli, S. Dall’Olio, L. Nanni Costa, M. Gallo, L. Fontanesi   +7 more
doaj   +1 more source

Unravelling the Genetic Structure of Local and Mainstream Red‐Pied Cattle Breeds Using Genomics and Extended Pedigree Analysis

Journal of Animal Breeding and Genetics, Volume 143, Issue 5, Page 705-718, September 2026.
ABSTRACT During the last decade, there has been a growing interest for local and endangered breeds as they are often seen as more resilient and healthier than mainstream breeds. They can also provide high added‐value products like meat or dairy products.
Margaux Vandewalle, Renzo Bonifazi, Jérémie Vandenplas, Sipke‐Joost Hiemstra, Gerben de Jong, Dirk Hinrichs, Nicolas Gengler, Hélène Wilmot   +7 more
wiley   +1 more source

Characterization of Lipizzan Horse Population From Lipica Stud Using Molecular and Pedigree Data

Animal Genetics, Volume 57, Issue 4, August 2026.
ABSTRACT In this study, we analysed genetic diversity, population structure and inbreeding in the Lipica Stud Farm population by integrating pedigree records, microsatellite (STR) and genome‐wide SNP data generated using the GGP Equine 70K BeadChip. The dataset comprised 233 horses from the Lipica Stud Farm, which served as the reference population for
Tamara Ferme, Minja Zorc, Marko Cotman, Matjaž Mesarič, Peter Dovč   +4 more
wiley   +1 more source

Multiple Eurasian Origins and Admixture Shaped the Genomic Legacy of the House Mouse Invasion in Africa

Molecular Ecology, Volume 35, Issue 16, August 2026.
ABSTRACT Commensal mammals offer unique opportunities to study how human‐mediated dispersal, admixture, and secondary contact shape genomic variation during range expansion, yet for one of the most successful invasive commensals globally, the western house mouse Mus musculus domesticus, invasion dynamics across Africa remain largely unexplored.
Daniel Poveda‐Martinez, Philippe Gauthier, Margaux J. M. Lefebvre, Fanny Degrugillier, Gauthier Dobigny, Jean‐Pierre Quéré, Ambroise Dalecky, Youssoupha Niang, Mamadou Kane, Clark Mbou‐Boutambe, Joa Mangombi, Solimane Ag Atteynine, Sylvestre Badou, Madougou Garba, Pierre Caminade, Barthélémy Ngoubangoye, Carole M. Smadja, Larson Boundenga, Laurent Granjon, Virginie Rougeron, Franck Prugnolle, Carine Brouat   +21 more
wiley   +1 more source

Autozygosity islands and ROH patterns in Nellore lineages: evidence of selection for functionally important traits

BMC Genomics, 2018
Background The aim of this study was to assess genome-wide autozygosity in a Nellore cattle population and to characterize ROH patterns and autozygosity islands that may have occurred due to selection within its lineages.
Elisa Peripolli, Julia Metzger, Marcos Vinícius Antunes de Lemos, Nedenia Bonvino Stafuzza, Sabrina Kluska, Bianca Ferreira Olivieri, Fabieli Louise Braga Feitosa, Mariana Piatto Berton, Fernando Brito Lopes, Danísio Prado Munari, Raysildo Barbosa Lôbo, Cláudio de Ulhoa Magnabosco, Fernando Di Croce, Jason Osterstock, Sue Denise, Angélica Simone Cravo Pereira, Fernando Baldi   +16 more
doaj   +1 more source