Results 31 to 40 of about 1,564 (152)

Are autozygosity estimates from imputed genotypes reliable?

Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP), 2022
Estimates of the inbreeding coefficient based on runs of homozygosity (FROH) are widely used in population genetics and livestock studies. The accuracy of FROH estimates is determined in part by the density of the genotyping chip. Compared with high density (HD) chips, low density (LD) chips tend to overestimate FROH in shorter homozygous segments.
Ferenčaković, Maja, Čurik, Ino
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Assessment and Distribution of Runs of Homozygosity in Horse Breeds Representing Different Utility Types

Animals, 2022
The present study reports runs of homozygosity (ROH) distribution in the genomes of six horse breeds (571 horses in total) representing three horse types (primitive, light, and draft horses) based on the 65k Equine BeadChip assay.
Tomasz Szmatoła, Artur Gurgul, Igor Jasielczuk, Ewa Oclon, Katarzyna Ropka-Molik, Monika Stefaniuk-Szmukier, Grazyna Polak, Iwona Tomczyk-Wrona, Monika Bugno-Poniewierska   +8 more
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Extensive genome-wide autozygosity in the population isolates of Daghestan [PDF]

European Journal of Human Genetics, 2015
Isolated populations are valuable resources for mapping disease genes, as inbreeding increases genome-wide homozygosity and enhances the ability to map disease alleles on a genetically uniform background within a relatively homogenous environment.
Tatiana M, Karafet, Kazima B, Bulayeva, Oleg A, Bulayev, Farida, Gurgenova, Jamilia, Omarova, Levon, Yepiskoposyan, Olga V, Savina, Krishna R, Veeramah, Michael F, Hammer   +8 more
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Pedigree and genome-based patterns of homozygosity in the South African Ayrshire, Holstein, and Jersey breeds

Frontiers in Genetics, 2023
The erosion of genetic diversity limits long-term genetic gain and impedes the sustainability of livestock production. In the South African (SA) dairy industry, the major commercial dairy breeds have been applying estimated breeding values (EBVs) and/or ...
Carina Visser, Simon Frederick Lashmar, Jason Reding, Donagh P. Berry, Donagh P. Berry, Esté van Marle-Köster   +5 more
doaj   +1 more source

GENOMIC VARIABILITY AMONG CATTLE POPULATIONS BASED ON RUNS OF HOMOZYGOSITY [PDF]

Poljoprivreda, 2015
In this work, the distribution of different lengths ROH (runs of homozygosity) in six cattle breeds was described. A total of 122 animals from six cattle breeds (Holstein, Simmental, Austrian Pinzgau, Ayrshire, MRI-Meuse Rhine Issel and Slovak Pinzgau ...
Veronika Šidlová, Radovan Kasarda, Nina Moravčíková, Anna Trakovická , Ino Curik, Maja Ferenčaković   +5 more
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The evaluation of genomic diversity and selection signals in the autochthonous Slovak Spotted cattle

Czech Journal of Animal Science, 2021
The aim of this study was to evaluate the effective population size based on linkage disequilibrium and the trend of inbreeding derived from runs of homozygosity (ROH) in the Slovak Spotted cattle.
Radovan Kasarda, Nina Moravčíková, Barbora Olšanská, Gábor Mészáros, Luboš Vostrý, Hana Vostrá-Vydrová, Kristína Lehocká, Ján Prišťák, Juraj Candrák   +8 more
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Fine-scale analysis of six beef cattle breeds revealed patterns of their genomic diversity

Italian Journal of Animal Science, 2020
There has been a significant decrease in genetic diversity on a global scale for several livestock species, including beef cattle. Therefore, the aim of this study was to deliver fine-scale analysis of the genomic structure and to describe the diversity ...
Radovan Kasarda, Nina Moravčíková, Luboš Vostrý, Zuzana Krupová, Emil Krupa, Kristína Lehocká, Barbora Olšanská, Anna Trakovická, Rudolf Nádaský, Peter Polák, Radoslav Židek, Ľubomír Belej, Jozef Golian   +12 more
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Pedigree and marker information requirements to monitor genetic variability

Genetics Selection Evolution, 2003
There are several measures available to describe the genetic variability of populations. The average inbreeding coefficient of a population based on pedigree information is a frequently chosen option.
Johann Sölkner, Roswitha Baumung
doaj   +1 more source

Runs of homozygosity for autozygosity estimation and genomic analysis in production animals [PDF]

Pesquisa Agropecuária Brasileira, 2018
: Runs of homozygosity (ROHs) are long stretches of homozygous genomic segments, identifiable by molecular markers, which can provide genomic information for accurate estimates to characterize populations, determine evolutionary history and demographic ...
Arnaldo Basso Rebelato, Alexandre Rodrigues Caetano   +1 more
doaj   +3 more sources

“Assessing the Impact of Individual Autozygosity on Complex Traits”

, 2022
Abstract Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity (ROHs) that arise when identical-by-descent (IBD) haplotypes are inherited from each parent ...
Megan T. Lynch, Kristin A. Maloney, Huichun Xu, James A. Perry, Alan R. Shuldiner, Braxton D. Mitchell, Regeneron Genetics Center N/A   +6 more
openaire   +1 more source