Results 31 to 40 of about 2,455 (150)

Autozygosity Mapping by Genome-wide Single Nucleotide Polymorphism Array Identifies a Novel Homozygous HR Mutation in a Consanguineous Family with Universal Hereditary Hair Loss

International Journal of Dermatology and Venerology, 2021
. Objective:. Isolated hereditary hypotrichosis is caused by mutations in as many as 11 different genes. The conventional mutation detection strategy consists of sequencing of individual candidate genes separately, a time consuming and costly approach ...
Sirous Zeinali, Leila Youssefian, Hassan Vahidnezhad, Amir Hossein Saeidian, Soheila Sotoudeh, Hamideh Bagherian, Jouni Uitto   +6 more
doaj   +1 more source

The Relationship between Runs of Homozygosity and Inbreeding in Jersey Cattle under Selection. [PDF]

PLoS ONE, 2015
Inbreeding is often an inevitable outcome of strong directional artificial selection but on average it reduces population fitness with increased frequency of recessive deleterious alleles. Runs of homozygosity (ROH) representing genomic autozygosity that
Eui-Soo Kim, Tad S Sonstegard, Curtis P Van Tassell, George Wiggans, Max F Rothschild   +4 more
doaj   +1 more source

Exploiting the Autozygome to Support Previously Published Mendelian Gene-Disease Associations: An Update

Frontiers in Genetics, 2020
There is a growing interest in standardizing gene-disease associations for the purpose of facilitating the proper classification of variants in the context of Mendelian diseases.
Sateesh Maddirevula, Hanan E. Shamseldin, Amy Sirr, Lama AlAbdi, Lama AlAbdi, Russell S. Lo, Nour Ewida, Mashael Al-Qahtani, Mais Hashem, Firdous Abdulwahab, Omar Aboyousef, Namik Kaya, Dorota Monies, May H. Salem, Naffaa Al Harbi, Hesham M. Aldhalaan, Hamad Alzaidan, Hamad Alzaidan, Hadeel M. Almanea, Abrar K. Alsalamah, Fuad Al Mutairi, Samira Ismail, Ghada M. H. Abdel-Salam, Amal Alhashem, Amal Alhashem, Ali Asery, Eissa Faqeih, Amal AlQassmi, Waleed Al-Hamoudi, Talal Algoufi, Mohammad Shagrani, Mohammad Shagrani, Aimée M. Dudley, Fowzan S. Alkuraya, Fowzan S. Alkuraya   +34 more
doaj   +1 more source

Effect of artificial selection on runs of homozygosity in u.s. Holstein cattle. [PDF]

PLoS ONE, 2013
The intensive selection programs for milk made possible by mass artificial insemination increased the similarity among the genomes of North American (NA) Holsteins tremendously since the 1960s.
Eui-Soo Kim, John B Cole, Heather Huson, George R Wiggans, Curtis P Van Tassell, Brian A Crooker, George Liu, Yang Da, Tad S Sonstegard   +8 more
doaj   +1 more source

Genetic Background and Inbreeding Depression in Romosinuano Cattle Breed in Mexico

Animals, 2021
The ultimate goal of genetic selection is to improve genetic progress by increasing favorable alleles in the population. However, with selection, homozygosity, and potentially harmful recessive alleles can accumulate, deteriorating genetic variability ...
Jorge Hidalgo, Alberto Cesarani, Andre Garcia, Pattarapol Sumreddee, Neon Larios, Enrico Mancin, José Guadalupe García, Rafael Núñez, Rodolfo Ramírez   +8 more
doaj   +1 more source

Assessment and Distribution of Runs of Homozygosity in Horse Breeds Representing Different Utility Types

Animals, 2022
The present study reports runs of homozygosity (ROH) distribution in the genomes of six horse breeds (571 horses in total) representing three horse types (primitive, light, and draft horses) based on the 65k Equine BeadChip assay.
Tomasz Szmatoła, Artur Gurgul, Igor Jasielczuk, Ewa Oclon, Katarzyna Ropka-Molik, Monika Stefaniuk-Szmukier, Grazyna Polak, Iwona Tomczyk-Wrona, Monika Bugno-Poniewierska   +8 more
doaj   +1 more source

Autozygosity mapping and time-to-spontaneous delivery in Norwegian parent-offspring trios [PDF]

, 2020
Parental genetic relatedness may lead to adverse health and fitness outcomes in the offspring. However, the degree to which it affects human delivery timing is unknown.
Flatley, Christopher, Zhang, Ge, Modzelewska, Dominika,, Jacobsson, Bo,, Modzelewska, Dominika, Muglia, Louis J., Vaudel, Marc, Helgeland, Øyvind, Andreassen, Ole, Jacobsson, Bo, Solé Navais, Pol,, Njølstad, Pål R, Njølstad, Pål Rasmus, Muglia, Louis J, Johansson, Stefan, Bacelis, Jonas, Bacelis, Jonas,, Solé-Navais, Pol   +17 more
core   +1 more source

Pedigree and genome-based patterns of homozygosity in the South African Ayrshire, Holstein, and Jersey breeds

Frontiers in Genetics, 2023
The erosion of genetic diversity limits long-term genetic gain and impedes the sustainability of livestock production. In the South African (SA) dairy industry, the major commercial dairy breeds have been applying estimated breeding values (EBVs) and/or ...
Carina Visser, Simon Frederick Lashmar, Jason Reding, Donagh P. Berry, Donagh P. Berry, Esté van Marle-Köster   +5 more
doaj   +1 more source

Autozygosity-driven genetic diagnosis in consanguineous families from Italy and the Greater Middle East [PDF]

, 2020
Autozygosity-driven exome analysis has been shown effective for identification of genes underlying recessive diseases especially in countries of the so-called Greater Middle East (GME), where high consanguinity unravels the phenotypic effects of ...
Al Khabouri M., Al Wardy N., Pisani F., Cantalupo G., Seri M., Palombo F., Carelli V., Brusco A., Giorgio E., Nouri N., Cordelli D. M., Gangarossa S., Magini P., Severi G., La Morgia C., Graziano C., Marconi C., Pippucci T., Al Kindi M. N., Romeo G., Salehi M.   +20 more
core   +3 more sources

Estimates of autozygosity through runs of homozygosity in farmed coho salmon

, 2020
Data file from the paper "Estimates of autozygosity through runs of homozygosity in farmed coho ...
José Manuel Yáñez (6201729), Grazyella Yoshida (4346728)   +1 more
core   +1 more source