Results 21 to 30 of about 2,455 (150)

Runs of Homozygosity Predict Inbreeding Depression Across Taxa: A Systematic Review and Meta‐Analysis [PDF]

Molecular Ecology, Volume 35, Issue 17, September 2026.
ABSTRACT Measuring inbreeding via runs of homozygosity (ROH) captures realized autozygosity and can infer inbreeding timing through ROH length. A growing body of literature links the proportion of the genome in ROH (FROH) to fitness outcomes across taxa, yet systematic synthesis has been lacking.
Julia C. Clarke, Rebecca S. Taylor, Micheline Manseau   +2 more
wiley   +2 more sources

Autozygosity influences cardiometabolic disease-associated traits in the AWI-Gen sub-Saharan African study [PDF]

Nature Communications, 2020
The prevalence of cardiometabolic diseases (CMDs) is increasing rapidly across Africa. Here, the authors investigate autozygosity in CMD-associated traits in over 10,000 sub-Saharan African individuals, showing these traits are influenced by sex-specific
Francisco C. Ceballos, Scott Hazelhurst, David W. Clark, Godfred Agongo, Gershim Asiki, Palwende R. Boua, F. Xavier Gómez-Olivé, Felistas Mashinya, Shane Norris, James F. Wilson, Michèle Ramsay   +10 more
doaj   +4 more sources

Machine‐Learning Models Trained on Genomic Summary Statistics Assess Extinction Risk and Recovery Potential of Bottlenecked Populations [PDF]

Evolutionary Applications, Volume 19, Issue 10, October 2026.
ABSTRACT Forecasting extinction risk from genomic data is challenging because of interactions among environment, demography, and genomic erosion. Here, we use known outcomes from forward simulations as a proof‐of‐concept study to test whether machine‐learning (ML) models can discriminate relative extinction risk and recovery potential from genomic ...
Johanna C. Winder, Jack N. Marsters, Thomas Birley, Jasmyn Gooding, Taoyang Wu, Jim J. Groombridge, Hernán E. Morales, Cock van Oosterhout   +7 more
wiley   +2 more sources

Autozygosity islands and ROH patterns in Nellore lineages: evidence of selection for functionally important traits [PDF]

BMC Genomics, 2018
Background The aim of this study was to assess genome-wide autozygosity in a Nellore cattle population and to characterize ROH patterns and autozygosity islands that may have occurred due to selection within its lineages.
Elisa Peripolli, Julia Metzger, Marcos Vinícius Antunes de Lemos, Nedenia Bonvino Stafuzza, Sabrina Kluska, Bianca Ferreira Olivieri, Fabieli Louise Braga Feitosa, Mariana Piatto Berton, Fernando Brito Lopes, Danísio Prado Munari, Raysildo Barbosa Lôbo, Cláudio de Ulhoa Magnabosco, Fernando Di Croce, Jason Osterstock, Sue Denise, Angélica Simone Cravo Pereira, Fernando Baldi   +16 more
doaj   +2 more sources

Weighted likelihood inference of genomic autozygosity patterns in dense genotype data [PDF]

BMC Genomics, 2017
Background Genomic regions of autozygosity (ROA) arise when an individual is homozygous for haplotypes inherited identical-by-descent from ancestors shared by both parents.
Alexandra Blant, Michelle Kwong, Zachary A. Szpiech, Trevor J. Pemberton   +3 more
doaj   +3 more sources

Assessment of Autozygosity Derived From Runs of Homozygosity in Jinhua Pigs Disclosed by Sequencing Data [PDF]

Frontiers in Genetics, 2019
Jinhua pig, a well-known Chinese indigenous breed, has evolved as a pig breed with excellent meat quality, greater disease resistance, and higher prolificacy.
Zhong Xu, Hao Sun, Zhe Zhang, Qingbo Zhao, Babatunde Shittu Olasege, Qiumeng Li, Yang Yue, Peipei Ma, Xiangzhe Zhang, Qishan Wang, Yuchun Pan, Yuchun Pan   +11 more
doaj   +2 more sources

Genome-wide autozygosity is associated with lower general cognitive ability [PDF]

, 2015
Inbreeding depression refers to lower fitness among offspring of genetic relatives. This reduced fitness is caused by the inheritance of two identical chromosomal segments (autozygosity) across the genome, which may expose the effects of (partially ...
Malhotra, A.K., Konte, B, Rujescu, D., Hansell, N., Andreassen, O.A., Sundet, K., Corley, R.P., Christoforou, A., Visscher, P.M., Montgomery, G W, Keller, M.C., Martin, N.G., Tenesa, A, Neale, B.M., Bitsios, P, Deary, I J, Lencz, T., Espeseth, T., Steen, V M, Hellard, S.L., Wright, M J, DeRosse, P, Keller, M C, Konte, B., Giegling, I, Steen, V.M., McRae, A.F., Djurovic, S., Melle, I., Davies, G, Christoforou, A, Ollier, W E, Payton, A, Montgomery, G.W., Howrigan, D P, Payton, A; id_orcid, Starr, J M, Liewald, D C, Hartmann, A M, Espeseth, T, Pendleton, N, Bitsios, P., Donohoe, G., Starr, J.M., Visscher, P M, Djurovic, S, Donohoe, G, Burdick, K E, Roussos, P., Reinvang, I, Tenesa, A., Davies, G., McRae, A., Wright, M.J., Horan, M., Glahn, D.C., Simonson, M A, Giakoumaki, S, Corley, R P, Ollier, W.E., Liewald, D.C., Harris, S.E., Rujescu, D, Harris, S E, Boomsma, D.I., Hellard, S L, Pendleton, N., Abdellaoui, A, Lencz, T, Boomsma, D I, Knowles, E E M, Lundervold, A.J., DeRosse, P., Neale, B M, Lundervold, A J, Burdick, K.E., Knowles, E.E.M., Abdellaoui, A., Sundet, K, Payton, A., Giegling, I., Giakoumaki, S., Hartmann, A.M., Reinvang, I., Howrigan, D.P., Malhotra, A K, Hansell, N, Melle, I, Simonson, M.A., Glahn, D C, Roussos, P, Boomsma, D.I.; id_orcid, Martin, N G, Andreassen, O A, McRae, A, Horan, M, Deary, I.J.   +96 more
core   +4 more sources

Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish

BMC Genomics, 2023
Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity
Megan T. Lynch, Kristin A. Maloney, Huichun Xu, James A. Perry, Regeneron Genetics Center, Alan R. Shuldiner, Braxton D. Mitchell   +6 more
doaj   +1 more source

Analysis of Homozygous-by-Descent (HBD) Segments for Purebred and Crossbred Pigs in Russia

Life, 2021
Intensive selection raises the efficiency of pig farming considerably, but it also promotes the accumulation of homozygosity, which can lead to an increase in inbreeding and the accumulation of deleterious variation.
Siroj Bakoev, Anatoly Kolosov, Faridun Bakoev, Olga Kostyunina, Nekruz Bakoev, Timofey Romanets, Olga Koshkina, Lyubov Getmantseva   +7 more
doaj   +1 more source

Ethiopian indigenous goats offer insights into past and recent demographic dynamics and local adaptation in sub‐Saharan African goats

Evolutionary Applications, 2021
Knowledge on how adaptive evolution and human socio‐cultural and economic interests shaped livestock genomes particularly in sub‐Saharan Africa remains limited.
Getinet M. Tarekegn, Negar Khayatzadeh, Bin Liu, Sarah Osama, Aynalem Haile, Barbara Rischkowsky, Wenguang Zhang, Kassahun Tesfaye, Tadelle Dessie, Okeyo A. Mwai, Appolinaire Djikeng, Joram M. Mwacharo   +11 more
doaj   +1 more source