Results 21 to 30 of about 2,131 (168)

Autozygosity influences cardiometabolic disease-associated traits in the AWI-Gen sub-Saharan African study [PDF]

Nature Communications, 2020
The prevalence of cardiometabolic diseases (CMDs) is increasing rapidly across Africa. Here, the authors investigate autozygosity in CMD-associated traits in over 10,000 sub-Saharan African individuals, showing these traits are influenced by sex-specific
Francisco C. Ceballos, Scott Hazelhurst, David W. Clark, Godfred Agongo, Gershim Asiki, Palwende R. Boua, F. Xavier Gómez-Olivé, Felistas Mashinya, Shane Norris, James F. Wilson, Michèle Ramsay   +10 more
doaj   +6 more sources

Autozygosity islands and ROH patterns in Nellore lineages: evidence of selection for functionally important traits [PDF]

BMC Genomics, 2018
Background The aim of this study was to assess genome-wide autozygosity in a Nellore cattle population and to characterize ROH patterns and autozygosity islands that may have occurred due to selection within its lineages.
Elisa Peripolli, Julia Metzger, Marcos Vinícius Antunes de Lemos, Nedenia Bonvino Stafuzza, Sabrina Kluska, Bianca Ferreira Olivieri, Fabieli Louise Braga Feitosa, Mariana Piatto Berton, Fernando Brito Lopes, Danísio Prado Munari, Raysildo Barbosa Lôbo, Cláudio de Ulhoa Magnabosco, Fernando Di Croce, Jason Osterstock, Sue Denise, Angélica Simone Cravo Pereira, Fernando Baldi   +16 more
doaj   +3 more sources

Autozygosity in a Turkish family with scoliosis, blindness, and arachnodactyly syndrome [PDF]

Annals of Saudi Medicine, 2015
BACKGROUND AND OBJECTIVES: Blindness-scoliosis-arachnodactyly syndrome has been described in a family with parental consanguinity. We present the strategy employed to determine the gene locus responsible for the syndrome.
Seda Orenay-Boyacioglu, Mustafa Tekin, Munis Dundar   +2 more
doaj   +3 more sources

Autozygosity mapping of Bardet-Biedl syndrome to 12q21.2 and confirmation of FLJ23560 as BBS10 [PDF]

European Journal of Human Genetics, 2007
Bardet-Biedl syndrome (BBS) is a genetically heterogeneous autosomal recessive disorder characterized by variable obesity, pigmentary retinopathy, polydactyly, mental retardation, hypogonadism and renal failure.
Maher, ER, Johnson, CA, Macdonald, F, MacDonald, Fiona, Banin, E, Maher, Eamonn, Stone, EM, Ahmed, S, Pasha, Shanaz, Trembath, RC, Smith, UM, Johnson, Colin, White, DRA, Rattenberry, E, Rajab, A, Nishimura, D, Raeburn, S, Pasha, S, Sheffield, VC, Stone, ED, Ganesh, A, White, DRE   +21 more
core   +5 more sources

Runs of homozygosity reveal genome-wide autozygosity in Italian sheep breeds [PDF]

Animal Genetics, 2018
The availability of dense single nucleotide polymorphism (SNP) assays allows for the determination of autozygous segments based on runs of consecutive homozygous genotypes (ROH).
Portolano, B., Ciani, E., M. T. Sardina, Sottile, G., B. Portolano, S. Mastrangelo, Sardina, M. T., Pilla, F., E. Ciani, F. Pilla, null null, G. Sottile, Mastrangelo, S.   +12 more
core   +4 more sources

Relationships between estimated autozygosity and complex traits in the UK Biobank.

PLoS Genetics, 2018
Inbreeding increases the risk of certain Mendelian disorders in humans but may also reduce fitness through its effects on complex traits and diseases. Such inbreeding depression is thought to occur due to increased homozygosity at causal variants that ...
Emma C Johnson, Luke M Evans, Matthew C Keller   +2 more
doaj   +5 more sources

A Dominant Founder Lineage Has Possible Fitness Costs for the Endangered Mexican Grey Wolf. [PDF]

Mol Ecol
ABSTRACT The Mexican grey wolf (Canis lupus baileyi) is an endangered and genetically distinct subspecies of grey wolf adapted to the warm climates of the southwestern United States and Mexico. Following centuries of eradication efforts, Mexican grey wolves were protected under the Endangered Species Act in 1976, prompting an international ex situ ...
Loera Y, Khakoo M, Krueckeberg E, Nilsson IG, Wu Z, Dwire M, Adams J, Waits L, Oakleaf JK, Campbell ML, Dunnum JL, Cook JA, vonHoldt BM.   +12 more
europepmc   +2 more sources

No Pedigree, No Problem: Genomic Inbreeding Tracks Genetic Rescue With High Resolution. [PDF]

Evol Appl
ABSTRACT With increasing habitat fragmentation and population isolation, inbreeding becomes a pressing concern for the persistence of wildlife populations. Detailed inbreeding monitoring is crucial for assessing extinction risk and evaluating the effectiveness of conservation management strategies.
Mitchell C, Deakin S, Festa-Bianchet M, Pelletier F, Coltman D.   +4 more
europepmc   +2 more sources

Assessment of Autozygosity Derived From Runs of Homozygosity in Jinhua Pigs Disclosed by Sequencing Data [PDF]

Frontiers in Genetics, 2019
Jinhua pig, a well-known Chinese indigenous breed, has evolved as a pig breed with excellent meat quality, greater disease resistance, and higher prolificacy.
Zhong Xu, Hao Sun, Zhe Zhang, Qingbo Zhao, Babatunde Shittu Olasege, Qiumeng Li, Yang Yue, Peipei Ma, Xiangzhe Zhang, Qishan Wang, Yuchun Pan, Yuchun Pan   +11 more
doaj   +3 more sources

Ethiopian indigenous goats offer insights into past and recent demographic dynamics and local adaptation in sub‐Saharan African goats

Evolutionary Applications, 2021
Knowledge on how adaptive evolution and human socio‐cultural and economic interests shaped livestock genomes particularly in sub‐Saharan Africa remains limited.
Getinet M. Tarekegn, Negar Khayatzadeh, Bin Liu, Sarah Osama, Aynalem Haile, Barbara Rischkowsky, Wenguang Zhang, Kassahun Tesfaye, Tadelle Dessie, Okeyo A. Mwai, Appolinaire Djikeng, Joram M. Mwacharo   +11 more
doaj   +1 more source