Results 21 to 30 of about 1,564 (152)

Analysis of Homozygous-by-Descent (HBD) Segments for Purebred and Crossbred Pigs in Russia

Life, 2021
Intensive selection raises the efficiency of pig farming considerably, but it also promotes the accumulation of homozygosity, which can lead to an increase in inbreeding and the accumulation of deleterious variation.
Siroj Bakoev, Anatoly Kolosov, Faridun Bakoev, Olga Kostyunina, Nekruz Bakoev, Timofey Romanets, Olga Koshkina, Lyubov Getmantseva   +7 more
doaj   +1 more source

Ethiopian indigenous goats offer insights into past and recent demographic dynamics and local adaptation in sub‐Saharan African goats

Evolutionary Applications, 2021
Knowledge on how adaptive evolution and human socio‐cultural and economic interests shaped livestock genomes particularly in sub‐Saharan Africa remains limited.
Getinet M. Tarekegn, Negar Khayatzadeh, Bin Liu, Sarah Osama, Aynalem Haile, Barbara Rischkowsky, Wenguang Zhang, Kassahun Tesfaye, Tadelle Dessie, Okeyo A. Mwai, Appolinaire Djikeng, Joram M. Mwacharo   +11 more
doaj   +1 more source

The Signatures of Autozygosity among Patients with Colorectal Cancer [PDF]

Cancer Research, 2008
Abstract Previous studies have shown that among populations with a high rate of consanguinity, there is a significant increase in the prevalence of cancer. Single nucleotide polymorphism (SNP) array data (Affymetrix, 50K XbaI) analysis revealed long regions of homozygosity in genomic DNAs taken from tumor and matched normal tissues of
Manny D, Bacolod, Gunter S, Schemmann, Shuang, Wang, Richard, Shattock, Sarah F, Giardina, Zhaoshi, Zeng, Jinru, Shia, Robert F, Stengel, Norman, Gerry, Josephine, Hoh, Tomas, Kirchhoff, Bert, Gold, Michael F, Christman, Kenneth, Offit, William L, Gerald, Daniel A, Notterman, Jurg, Ott, Philip B, Paty, Francis, Barany   +18 more
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Human population structure, genome autozygosity and human health [PDF]

Genome Medicine, 2009
A major transition in human population structure is currently under way, moving from a historical metapopulation, comprising small and mainly rural endogamous communities, to large and increasingly panmictic urban populations. This process is predicted to increase outbreeding, and preliminary data from genomic surveys have helped to quantify the ...
Campbell, H., Rudan, I., Bittles, A.H., Wright, A.F.   +3 more
openaire   +5 more sources

Autozygosity Mapping by Genome-wide Single Nucleotide Polymorphism Array Identifies a Novel Homozygous HR Mutation in a Consanguineous Family with Universal Hereditary Hair Loss

International Journal of Dermatology and Venerology, 2021
. Objective:. Isolated hereditary hypotrichosis is caused by mutations in as many as 11 different genes. The conventional mutation detection strategy consists of sequencing of individual candidate genes separately, a time consuming and costly approach ...
Sirous Zeinali, Leila Youssefian, Hassan Vahidnezhad, Amir Hossein Saeidian, Soheila Sotoudeh, Hamideh Bagherian, Jouni Uitto   +6 more
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The Relationship between Runs of Homozygosity and Inbreeding in Jersey Cattle under Selection. [PDF]

PLoS ONE, 2015
Inbreeding is often an inevitable outcome of strong directional artificial selection but on average it reduces population fitness with increased frequency of recessive deleterious alleles. Runs of homozygosity (ROH) representing genomic autozygosity that
Eui-Soo Kim, Tad S Sonstegard, Curtis P Van Tassell, George Wiggans, Max F Rothschild   +4 more
doaj   +1 more source

Genome‐wide autozygosity mapping in human populations [PDF]

Genetic Epidemiology, 2008
AbstractIndividuals are frequently observed to have long segments of uninterrupted sequences of homozygous markers. One of the major mechanisms that gives rise to such long homozygous segments is consanguineous marriages, where parents pass shared chromosomal segments to their child. Such chromosomal segments are also known as autozygous segments.
Shuang, Wang, Chad, Haynes, Francis, Barany, Jurg, Ott   +3 more
openaire   +2 more sources

Exploiting the Autozygome to Support Previously Published Mendelian Gene-Disease Associations: An Update

Frontiers in Genetics, 2020
There is a growing interest in standardizing gene-disease associations for the purpose of facilitating the proper classification of variants in the context of Mendelian diseases.
Sateesh Maddirevula, Hanan E. Shamseldin, Amy Sirr, Lama AlAbdi, Lama AlAbdi, Russell S. Lo, Nour Ewida, Mashael Al-Qahtani, Mais Hashem, Firdous Abdulwahab, Omar Aboyousef, Namik Kaya, Dorota Monies, May H. Salem, Naffaa Al Harbi, Hesham M. Aldhalaan, Hamad Alzaidan, Hamad Alzaidan, Hadeel M. Almanea, Abrar K. Alsalamah, Fuad Al Mutairi, Samira Ismail, Ghada M. H. Abdel-Salam, Amal Alhashem, Amal Alhashem, Ali Asery, Eissa Faqeih, Amal AlQassmi, Waleed Al-Hamoudi, Talal Algoufi, Mohammad Shagrani, Mohammad Shagrani, Aimée M. Dudley, Fowzan S. Alkuraya, Fowzan S. Alkuraya   +34 more
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Effect of artificial selection on runs of homozygosity in u.s. Holstein cattle. [PDF]

PLoS ONE, 2013
The intensive selection programs for milk made possible by mass artificial insemination increased the similarity among the genomes of North American (NA) Holsteins tremendously since the 1960s.
Eui-Soo Kim, John B Cole, Heather Huson, George R Wiggans, Curtis P Van Tassell, Brian A Crooker, George Liu, Yang Da, Tad S Sonstegard   +8 more
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Genetic Background and Inbreeding Depression in Romosinuano Cattle Breed in Mexico

Animals, 2021
The ultimate goal of genetic selection is to improve genetic progress by increasing favorable alleles in the population. However, with selection, homozygosity, and potentially harmful recessive alleles can accumulate, deteriorating genetic variability ...
Jorge Hidalgo, Alberto Cesarani, Andre Garcia, Pattarapol Sumreddee, Neon Larios, Enrico Mancin, José Guadalupe García, Rafael Núñez, Rodolfo Ramírez   +8 more
doaj   +1 more source