Results 51 to 60 of about 207,582 (294)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Dynamic model of fiber bundles
, 2004 A realistic continuous-time dynamics for fiber bundles is introduced and studied both analytically and numerically. The equation of motion reproduces known stationary-state results in the deterministic limit while the system under non-vanishing stress ...
B.-G Yoon +6 more
core +1 more source
Focal adhesions as mechanosensors: the two-spring model [PDF]
, 2004 Adhesion-dependent cells actively sense the mechanical properties of their environment through mechanotransductory processes at focal adhesions, which are integrin-based contacts connecting the extracellular matrix to the cytoskeleton.
Schwarz, Ulrich S. +2 more
core +2 more sources
Intraoperative rupture cerebral aneurysm and computational flow dynamics
Asian Journal of Neurosurgery, 2018 Intraoperative aneurysmal rupture (IAR) is the most fearsome complication of aneurysm surgery. IAR associates with high morbidity and mortality. In recent years, we have many studies regarding using computational fluid dynamics (CFD) in aneurysm surgery.
Senko, Ilya +7 more
openaire +3 more sources
Ultrafast ultrasound captures dynamic rupture behavior [PDF]
Proceedings of Meetings on Acoustics, 2018 We apply shear wave elastography, a medical imaging technique that uses ultrafast ultrasound to analyze rupture nucleation. In order to better understand friction and rupture processes which are responsible for earthquake nucleation, we build a laboratory experiment that reproduces the stick-slip behavior of a seismic fault for soft elastic materials ...
Aichele, Johannes +4 more
openaire +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Quasi-static stationary-periodic model of percussive deep drilling [PDF]
, 2005 Copyright @ 2005 Patron EditoreIn the percussively deep drilling, the rock is modeled by an infinite elastic medium with a semi-infinite cylindrical bore-hole having a curvilinear bottom.
Mikhailov, SE, Namestnikova, IV
core
On the speed of fast and slow rupture fronts along frictional interfaces [PDF]
, 2015 The transition from stick to slip at a dry frictional interface occurs through the breaking of the junctions between the two contacting surfaces. Typically, interactions between the junctions through the bulk lead to rupture fronts propagating from weak ...
Malthe-Sørenssen, Anders +4 more
core +3 more sources
Frontiers in Neurology, 2023 Background and purposeThe translucent area on the surface of intracranial aneurysms (IAs) is associated with rupture risk. In the present study, the Polyflow module of the Ansys software was used to simulate and analyze the thickness of the aneurysm wall
Xin-xin Fan +11 more
doaj +1 more source
Stochastic Dynamics for Earthquake Ruptures
, 2018 In this paper, we propose a stochastic dynamic model for earthquake rupture and suggest that the Langevin equation of frictions may be used for interpreting the slip distributions of rupture processes in earthquakes. The steady-state solution of the derived Langevin equation analytically attains the truncated exponential (TEX) distribution that is ...
Wu, Tsung-Hsi, Chen, Chien-Chih
openaire +2 more sources