Results 91 to 100 of about 11,434,443 (306)

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini   +12 more
wiley   +1 more source

Elastic and statistically brittle (ESB) model, damage localization and catastrophic rupture

open access: yes, 2007
In this paper, an elastic and statistically brittle (ESB) model is applied to the process of damage evolution induced catastrophic rupture and the influence of localization and softening on catastrophic rupture is discussed.
Bai YL(白以龙)   +2 more
core   +2 more sources

Wire Rupture Optimization in Wire Electrical Discharge Machining using Taguchi Approach

open access: yesMATEC Web of Conferences, 2017
Wire electrical discharge machining (WEDM) is one of the most important nontraditional machining process that is well-known for cutting difficult to machine materials. The wire electrode along with machining parameters control the WEDM process.
Maher Ibrahem   +2 more
doaj   +1 more source

How Does Dissipation Affect the Transition from Static to Dynamic Macroscopic Friction?

open access: yesLubricants, 2015
Description of the transitional process from a static to a dynamic frictional regime is a fundamental problem of modern physics. Previously, we developed a model based on the well-known Frenkel-Kontorova model to describe dry macroscopic friction.
Naum I. Gershenzon   +2 more
doaj   +1 more source

Influence of disorder on the rupture process of fibrous materials

open access: yesPhysica A: Statistical Mechanics and its Applications, 2010
Abstract Based on computational modelling the influence of disorder on the rupture process of fibrous materials have been evaluated. This has been done by simulating a bundle of parallel fibers under a constant uniaxial force. The disorder process was introduced by randomly assigning a strength threshold to each fiber of the bundle according to the ...
I.L. Menezes-Sobrinho, A.L.S. Rodrigues
openaire   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram   +3 more
wiley   +1 more source

An investigation into accelerated rehabilitation strategies following an achilles tendon rupture [PDF]

open access: yes
Background Rupture of the Achilles tendon occurs in over 11,000 people annually in the UK. Traditional management using cast immobilisation is being slowly replaced by immediate weight bearing rehabilitation, but currently there is no consensus ...
Kearney, Rebecca S.
core  

The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta   +11 more
wiley   +1 more source

Investigation into Mechanism of Floor Dynamic Rupture by Evolution Characteristics of Stress and Mine Tremors: A Case Study in Guojiahe Coal Mine, China

open access: yesShock and Vibration, 2018
In order to explore the mechanism of floor dynamic rupture, the current study adopts a thin plate model to further investigate the condition of floor failure.
Guangjian Liu   +5 more
doaj   +1 more source

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