ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini +12 more
wiley +1 more source
Elastic and statistically brittle (ESB) model, damage localization and catastrophic rupture
In this paper, an elastic and statistically brittle (ESB) model is applied to the process of damage evolution induced catastrophic rupture and the influence of localization and softening on catastrophic rupture is discussed.
Bai YL(白以龙) +2 more
core +2 more sources
Wire Rupture Optimization in Wire Electrical Discharge Machining using Taguchi Approach
Wire electrical discharge machining (WEDM) is one of the most important nontraditional machining process that is well-known for cutting difficult to machine materials. The wire electrode along with machining parameters control the WEDM process.
Maher Ibrahem +2 more
doaj +1 more source
How Does Dissipation Affect the Transition from Static to Dynamic Macroscopic Friction?
Description of the transitional process from a static to a dynamic frictional regime is a fundamental problem of modern physics. Previously, we developed a model based on the well-known Frenkel-Kontorova model to describe dry macroscopic friction.
Naum I. Gershenzon +2 more
doaj +1 more source
Influence of disorder on the rupture process of fibrous materials
Abstract Based on computational modelling the influence of disorder on the rupture process of fibrous materials have been evaluated. This has been done by simulating a bundle of parallel fibers under a constant uniaxial force. The disorder process was introduced by randomly assigning a strength threshold to each fiber of the bundle according to the ...
I.L. Menezes-Sobrinho, A.L.S. Rodrigues
openaire +1 more source
White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram +3 more
wiley +1 more source
Parametrical Function Describing Influences of the Redistribution of Incorporated Oil for Rupture Process Reconstruction in Rubber. [PDF]
Datta S, Stoček R, Harea E.
europepmc +1 more source
An investigation into accelerated rehabilitation strategies following an achilles tendon rupture [PDF]
Background Rupture of the Achilles tendon occurs in over 11,000 people annually in the UK. Traditional management using cast immobilisation is being slowly replaced by immediate weight bearing rehabilitation, but currently there is no consensus ...
Kearney, Rebecca S.
core
The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease
ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta +11 more
wiley +1 more source
In order to explore the mechanism of floor dynamic rupture, the current study adopts a thin plate model to further investigate the condition of floor failure.
Guangjian Liu +5 more
doaj +1 more source

