Results 31 to 40 of about 202,733 (217)

Role of a Hidden Fault in the Early Process of the 2024 Mw7.5 Noto Peninsula Earthquake

Geophysical Research Letters
The 2024 Mw 7.5 Noto Peninsula, Japan, earthquake was initiated within the source region of intense swarm activity. To reveal the mainshock early process, we relocated the earthquake hypocenters and found that many key phenomena, including the mainshock ...
Keisuke Yoshida, Ryota Takagi, Yo Fukushima, Ryosuke Ando, Yusaku Ohta, Yoshihiro Hiramatsu   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Source rupture process of the Kocaeli, Turkey, earthquake of August 17, 1999, obtained by joint inversion of near‐field data and teleseismic data

Geophysical Research Letters, 2000
The rupture process of the 1999 Turkey earthquake is examined using both near‐field strong motion data and teleseismic body wave data. The derived source parameters are as follows: (strike, dip, slip) = (268°, 86°, 180°), nearly pure strike‐slip; the ...
Yuji Yagi, Masayuki Kikuchi
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

A multiple asymmetric bilateral rupture sequence derived from the peculiar tele-seismic P-waves of the 2025 Mandalay, Myanmar earthquake

Seismica
A large strike-slip earthquake occurred in central Myanmar on March 28, 2025. The aftershock distribution suggests that the rupture of the mainshock propagated mainly to the south. However, a large-amplitude phase lasting 20 s, followed by a short-period
Naohiro Inoue, Ryo Yamaguchi, Yuji Yagi, Ryo Okuwaki, Enescu Bogdan, Tira Tadapansawut   +5 more
doaj   +1 more source

Dynamic rupture of metal sheet subjected to laser irradiation and tangential subsonic airflow

Theoretical and Applied Mechanics Letters, 2018
: To reproduce the premature rupture process of metal sheet subjected to laser irradiation with subsonic airflow, which is an interesting phenomenon observed in the experiments given by Lawrence Livermore National Laboratory, a coupled numerical model ...
Xiaodong Xing, Te Ma, Ruixing Wang, Chenyu Cao, Hongwei Song, Chenguang Huang   +5 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source