Results 51 to 60 of about 549,283 (299)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

The 2007 Azores earthquakes: A case of triggering? [PDF]

open access: yes, 2009
On 5 April (Mw=6.3) and 7 April 2007 (Mw=6.1 ) two earthquakes occur at the Formigas Islets (Azores Islands), both with same epicenter and felt (I=V/VI MSK) in S. Miguel Island.
Bezzghoud, M   +3 more
core  

Mechanical compression to characterize the robustness of liquid marbles [PDF]

open access: yes, 2015
In this work, we have devised a new approach to measure the critical pressure that a liquid marble can withstand. A liquid marble is gradually squeezed under a mechanical compression applied by two parallel plates.
Binks, Bernard P.   +3 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tsunami generation by ocean floor rupture front propagation: Hamiltonian description [PDF]

open access: yes, 2009
The Hamiltonian method is applied to the problem of tsunami generation caused by a propagating rupture front and deformation of the ocean floor. The method establishes an alternative framework for analyzing the tsunami generation process and produces ...
Pavlov, V. I., Tito, E. P., Tromp, J.
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Study of the fracture process of Al Hoceima earthquake (24/02/2004, Mw=6.2) from regional and teleseismic data. [PDF]

open access: yes, 2005
We studied the source time function (STF) and rupture process of the 2004 Alhoceima, Morocco earthquake of Mw = 6.2 using teleseismic and regional broad-band data. From regional broad-band data, STF function was determined using three large after- shocks
Bezzghoud, M   +4 more
core  

Andrade, Omori and Time-to-failure Laws from Thermal Noise in Material Rupture

open access: yes, 2003
Using the simplest possible ingredients of a rupture model with thermal fluctuations, we provide an analytical theory of three ubiquitous empirical observations obtained in creep (constant applied stress) experiments: the initial Andrade-like and Omori ...
A. Saichev, D. Sornette, T. Utsu
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

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