Results 51 to 60 of about 11,434,443 (306)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Rupture process of the 2023 MW 6.1 Jishishan (China) earthquake in a compressional stress regime and implications for seismic hazards

Geomatics, Natural Hazards & Risk
On 18 December 2023, an MW 6.1 earthquake struck Jishishan County, China, and occurred on a blind thrust fault at the northeastern edge of the Tibetan Plateau.
Xiangyun Guo, Xu Zhang, Xinxin Yin, Lei Yi, Anjian Wang, Chaoyong Peng, Shiguang Wang, Bo Zhang, Long Zhang, Zhenyue Li   +9 more
doaj   +1 more source

Ex vivo Follicle Rupture and in situ Zymography in Drosophila

Bio-Protocol, 2018
Ovulation, the process of releasing a mature oocyte from the ovary, is crucial for animal reproduction. In order for the process of ovulation to occur, a follicle must be fully matured and signaled to rupture from the ovary.
Elizabeth Knapp, Lylah Deady, Jianjun Sun   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Dual Mechanism Transition Controls Rupture Development of Large Deep Earthquakes

AGU Advances
Deep earthquakes at depths below 500 km are under prohibitive pressure and temperature conditions for brittle failure. Individual events show diverse rupture behaviors and a coherent mechanism to explain their rupture nucleation, propagation, and ...
Zhe Jia, Wenyuan Fan, Wei Mao, Peter M. Shearer, Dave A. May   +4 more
doaj   +1 more source

Quick output parameters related to the 7 January 2025 M6.8 earthquake in Dingri County, Xizang

地震科学进展
At 09:05 on January 7, 2025 (Beijing time), a magnitude 6.8 earthquake occurred in Dingri, Xizang Autonomous Region. The Institute of Geophysics, China Earthquake Administration launched a rapid earthquake emergency response after the earthquake, and ...
Kun Chen, Ting Yang, Yongzhe Wang, Xiangyun Guo, Zhe Zhang, Xu Zhang, Ruifeng Liu   +6 more
doaj   +1 more source

Geometry of Active Faults and Their Rupture Process.

The Quaternary Research (Daiyonki-Kenkyu), 2000
活断層の情報として,最も基本的な情報である地表分布形態のうち,断層の分岐形態,横ずれ断層の縦ずれ変位分布パターン,断層線に沿った変位の累積過程は,断層の破壊過程に密接に関連し,地震動予測のために不可欠な情報源となることを予測する.また,これまで地震発生前には不可能であった破壊開始点や破壊伝播方向の予測やセグメント区分および活断層の発生に関して,新たな視点を提示する.
Nakata, Takashi, Suzuki, Yasuhiro
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Quick output parameters related to the 2 December 2023 MW7.6 Mindanao, Philippines earthquake

地震科学进展
At 22:37 on December 2, 2023 (Beijing time), a M7.6 earthquake occurred in the eastern waters of Mindanao，Philippines. The Institute of Geophysics, China Earthquake Administration initiated the response mechanism after this earthquake and organized ...
Yongzhe Wang, Xu Zhang, Zhe Zhang, Kun Chen, Ruifeng Liu   +4 more
doaj   +1 more source

Fatigue crack growth under pulsatile pressure and plaque rupture

, 2014
Identification of vulnerable plaque pre-rupture is extremely important for patient risk stratification. The mechanism of plaque rupture is still not entirely clear, but it is thought to be a process involving multiple factors.
Tang, T. Y., Li, Z. Y., Pei, X., Wu, B. J., Gillard, J. H.   +4 more
core   +1 more source