Results 131 to 140 of about 12,767 (235)

RWD insights into the global cost of Alzheimer’s and dementia

Alzheimer's & Dementia
AbstractIt is well recognised that Alzheimer’s disease and related dementia disorders (ADRD) are associated with very high societal costs. The total global costs of dementia have been estimated to over 1.3 trillion US$ annually (Wimo, Seeher et al. 2023).
openaire   +1 more source

Innovative Clinical Trial Approach for Evaluating Digital Medical Devices Under European Fast-Track Regulatory Frameworks. [PDF]

Stat Med
Ursino M, Boulet S, Collignon C, Francis-Oliviero F, Lhomme E, Porcher R, Saillour F, Varoquaux G, Vercamer V, Thiébaut R, Zohar S.   +10 more
europepmc   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

COVID-19 RWD processing

Report on the data processing activities related to data harvest curation normalization and validation of the COVID19 data as identified in WP1 Task 31 and Task 32 ...
openaire   +1 more source

Editorial: Utilizing real-world evidence for better endocrine health management. [PDF]

Front Endocrinol (Lausanne)
Mei M, Lopes LC, Li C.
europepmc   +1 more source

Do the biological characteristics of trout (Salmo trutta) smolts influence their spring migration timing and maiden marine sojourn duration?

Journal of Fish Biology, EarlyView.
Abstract Anadromous salmonids migrate seaward to exploit feeding and growth opportunities in marine habitats, yet how smolt biological characteristics influence their marine migratory behavior remains poorly understood. This study used 9 years of trout (Salmo trutta) population monitoring data from 15,595 tagged age‐0+ parr, 1033 smolts detected ...
Jonathan P. Gillson, Robert E. Blackwell, Stephen D. Gregory, Jessica E. Marsh, Tea Bašić, Sophie A. M. Elliott, R. Andrew King, David L. Maxwell, William D. Riley, Jamie R. Stevens, Alan M. Walker, Rasmus B. Lauridsen   +11 more
wiley   +1 more source

Contrasting life‐history strategies of three sympatric icefish species in the northern Scotia Sea

Journal of Fish Biology, EarlyView.
Abstract Comprehending a species' life‐history strategies is crucial to inform effective conservation efforts. Commercial fishing impacts icefish (family: Channichthyidae) in the Scotia Sea, but detailed information on species‐specific life histories remains largely unknown.
Huw W. James, Timothy Jones, Fabrice Stephenson, Philip R. Hollyman, William D. K. Reid, Martin A. Collins   +5 more
wiley   +1 more source

RWD insights into the use, safety and effectiveness of novel treatments

Alzheimer's & Dementia
AbstractIn Japan, the regulatory authority approved the drug in September 2023, and on December 20, it became available for prescription country‐wide under the health insurance system. However, there are strict patient, physician, and facility requirements for the prescription of Lecanemab, and various problems are anticipated in its future ...
openaire   +1 more source

Dynamic Vibration Analysis and Suppression Research of Reamer String While Drilling

Shiyou jixie
In the application of ream while drilling technology， there are still several issues such as severe vibration of drill string system leading to cutter fragmentation and thread joint failure， complex stress state of long string under complex drilling ...
Hou Fuxiang, Yu Fusheng, Zhang Yanping, Li Jiayuan, Guan Ning, Li Yang   +5 more
doaj  

Defining a standards framework for ophthalmology real-world data methodologies through an expert-led Delphi consensus. [PDF]

Eye (Lond)
Gabrielle PH, Bandello F, Couturier A, Dinah C, Downey A, Invernizzi A, Khanani AM, Rocha JCP, Saffar I, Zarranz-Ventura J, Singh RP.   +10 more
europepmc   +1 more source