Results 131 to 140 of about 14,665 (304)

Opportunities and Challenges for AI-Based Analysis of RWD in Pharmaceutical R&D: A Practical Perspective [PDF]

Real world data (RWD) has become an important tool in pharmaceutical research and development. Generated every time patients interact with the healthcare system when diagnoses are developed and medical interventions are selected, RWD are massive and in ...
Burghaus, Rolf, Lippert, Jörg, Diedrich, Christian, Behr, Merle   +3 more
core   +1 more source

Bridging Real-World Data Gaps: Connecting Dots Across 10 Asian Countries

JMIR Medical Informatics
The economic trend and the health care landscape are rapidly evolving across Asia. Effective real-world data (RWD) for regulatory and clinical decision-making is a crucial milestone associated with this evolution.
Guilherme Silva Julian, Wen-Yi Shau, Hsu-Wen Chou, Sajita Setia   +3 more
doaj   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal

Periodontology 2000, EarlyView., 2023
Abstract In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news‐room/fact‐sheets/detail ...
Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard   +3 more
wiley   +1 more source

Beyond wound sealing: A dual‐functional adhesive nanofiber membrane promoting coagulation and osteogenesis in extraction sites

BMEMat, EarlyView.
Inspired by the suction mechanics of octopus suckers, a dual‐layer nanofiber membrane integrates antibacterial protection, strong wet adhesion, and osteogenic support, offering a bioinspired strategy for effective hemostasis and alveolar bone preservation.
Huijing Ma, Liheng Gao, Hao Liang, Wentao Jiang, Junyi Wang, Jiajia Wang, Shuhan Duan, Lingxi Meng, Adilijiang Yimiti, Wenjie Zhang   +9 more
wiley   +1 more source

A bioinspired catalytic nanoplatform for ferroptosis‐immunotherapy synergy in metastatic cancer

BMEMat, EarlyView.
The bioinspired nanoplatform MnMSN@MnP‐PEG co‐delivers manganese peroxidase and manganese ions to synergistically induce immunogenic ferroptosis and activate the cGAS‐STING pathway, eliciting potent antitumor immunity against primary and metastatic tumors.
Panpan Xue, Hai Cai, Ying Sun, Yaxin Ma, Siyuan Liu, Jinying Zhu, Yan Chen, Xuemei Zeng, Shuangqian Yan   +8 more
wiley   +1 more source

Resolution based on the results of the V annual scientific-practical conference "RWD/RWE. Possible and real" [PDF]

On September 19, 2024, in Moscow (Russian Federation), the V annual scientific-practical conference with international participation "RWD/RWE. Possible and Real" were organized and held.
D. Yu. Belousov, M. A. Borzova, A. S. Kolbin, V. V. Kalinichenko   +3 more
core   +2 more sources

Lower AKI Risk and Higher Survival With Microaxial Flow Pump Support During Elective PCI: A Propensity Score‐Matched Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Acute kidney injury (AKI) is associated with worse outcomes after percutaneous coronary intervention (PCI). Previous, smaller studies suggested nephroprotective effects of micro‐axial flow pump (mAFP) during PCI. This study aimed to compare renal outcomes of high‐risk PCI with mAFP or intraaortic balloon pump (IABP) support.
Elric Zweck, Andrew Shaw, Amin Polzin, Nudrat Noor, Sathya Unudurthi, Michael Cuchiara, Kai M. Schmidt‐Ott, Malte Kelm, Ralf Westenfeld, Rafael Kramann, Ravindra L. Mehta   +10 more
wiley   +1 more source

Optimizing Highway Funds by Integrating RWD Data into PMS Decision Making [PDF]

, 2015
Pavement structural response is an important indicator of pavement structural capacity, which influences performance measures, such as cracking. Traditionally, pavement management systems have tracked performance using condition indices based on visual ...
Van, Thomas P., Beckemeyer, Curt A., Steele, Douglas A.   +2 more
core  

LONGITUDINAL PERFORMANCE OPTIMIZATION OF RWD VEHICLE

Perner’s Contacts, 2019
The longitudinal performance of a vehicle is the ability to achieve the highest longitudinal acceleration on the given road surface and tyres. The engine is capable of high torque delivery especially in low vehicle speed. A pre-emptive controller has been deployed to control the torque delivery where tyres are being used in their peak friction area.
openaire   +1 more source