Results 251 to 260 of about 14,665 (304)

Diosgenin Alleviates Age‐Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1/PGC‐1α Signaling Pathway

Aging Cell, Volume 25, Issue 8, August 2026.
As a critical bioactive component of Polygonatum sibiricum, diosgenin improves age‐related declines in skeletal muscle mass and function by activating the SIRT1/PGC‐1α pathway, upregulating the expression of the myokine METRNL and IGF‐1, and promoting satellite cell proliferation and myogenic differentiation.
Xin Zeng, Han Ding, Ziye Li, Qian Wang, Peiyao Guan, Tingting Wang, Jiayun Wang, Yansong Fu, Lizhang Chen, Hong Qin   +9 more
wiley   +1 more source

Integrating B Cell Differentiation Model With Real-World Data Informs Determinants for Antibody-Secreting Cell Depletions in Systemic Sclerosis. [PDF]

CPT Pharmacometrics Syst Pharmacol
Nakada T, Saito R, Ishigaki S, Takei H, Yoshimoto K, Akiyama M, Takeuchi T, Kaneko Y, Miyoshi F.   +8 more
europepmc   +1 more source

Prognostic factors of optical coherence tomography angiography in intermediate and advanced primary open‐angle glaucoma: A systematic review and meta‐analysis

Acta Ophthalmologica, Volume 104, Issue 5, Page e491-e502, August 2026.
Abstract Conventional optical coherence tomography (OCT) has a floor effect in patients with severe visual field loss, such as seen in advanced primary open‐angle glaucoma (POAG). OCT angiography (OCTA) does not suffer from such a floor effect. However, which OCTA parameters are most useful for monitoring longitudinal progression is unclear.
Kamya Katarya, Victor A. de Vries, João Barbosa‐Breda, Luisa Sanchez Brea, Danilo Andrade De Jesus, Wishal D. Ramdas   +5 more
wiley   +1 more source

Evaluating Data Quality by Proxy: Can We Evaluate All Dimensions of the European Medicines Agency Data Quality Framework for Registry-Based Post-Authorization Safety Studies? [PDF]

Pharmacoepidemiol Drug Saf
Dobay P, Sabidó M.
europepmc   +1 more source

Cesni‐cel (ARI0002h) in ultra‐high‐risk multiple myeloma with plasma cell leukaemia or central nervous system involvement

British Journal of Haematology, Volume 209, Issue 2, Page 610-620, August 2026.
ARI0002h induced response in 15/17 patients with plasma cell leukaemia (PCL)/central nervous system (CNS)‐multiple myeloma (MM) (87% achieved ≥ very good partial response [VGPR]) with a median progression‐free survival (PFS)/overall survival (OS) of 10.5 and 15.9 months respectively.
Carlos Jimenez‐Mira, Natalia Tovar, Núria Martínez‐Cibrián, Verónica González‐Calle, Nil Albiol, Nieves López‐Muñoz, Aina Oliver‐Caldés, Azucena González, José Miguel Mateos, Marta Español‐Rego, Laura Rosiñol, Manel Juan, Paola Charry, José María Sanchez‐Pina, Sergio Navarro, Daniel Munárriz, Lucía López‐Corral, Valentín Ortiz‐Maldonado, Sara Varea, Eulalia Olesti, Julio Delgado, Álvaro Urbano‐Ispizua, Joaquín Martínez‐López, María Victoria Mateos, Luis Gerardo Rodríguez‐Lobato, Carlos Fernández de Larrea   +25 more
wiley   +1 more source

Benzbromarone as a Novel Candidate for Preventing Alzheimer's Disease: Evidence From Real-World Data Screening and in Vitro Validation. [PDF]

Clin Transl Sci
Sakagami S, Yoshida Y, Uemura S, Kumamoto T, Tsukamoto R, Nishi T, Kawano S, Fukuoka K, Ino H, Hamamura K, Ohdo S, Matsunaga N.   +11 more
europepmc   +1 more source

A Simulation‐Based Assessment of Dosage Regimen Appropriateness for Multiple Myeloma Medicines Reflecting Demographic and Ethnic Differences

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Bridging studies are often waived for orphan diseases such as multiple myeloma (MM) due to challenges in conducting clinical trials in small and heterogeneous populations. However, demographic and regional differences between trial participants and Asian populations may influence drug exposure and response.
Minji Kang, Suein Choi, Sung‐Soo Park, Sungpil Han, Seunghoon Han   +4 more
wiley   +1 more source

Introducing the J-CONNECT database: a real-world oncology resource for Japan. [PDF]

Int J Clin Oncol
Okada M, Matsumoto S, Maehara Y, Kanayama T, Lambrelli D, Koga T, Muto M.   +6 more
europepmc   +1 more source

OPTIMIZATION OF DRIVING TECHNIQUE OF RWD RACING CAR FOR FASTER CORNERING

Journal of KONES. Powertrain and Transport, 2015
openaire   +2 more sources

Exploring Risks of Adverse Drug Events From Single Drug to Three‐Drug Combination

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Use of three‐drug combinations is common and could increase the risk of adverse drug events (ADEs). Signals of ADEs from three‐drug combinations could be identified from real‐world data, and the risks of ADEs from single drug exposure to three‐drug combination exposure could be illustrated by a graphic model.
Yi Shi, Anna Sun, Chien‐Wei Chiang, Yuedi Yang, Katherine M. Hunold, Jing Xu, Mu Shan, Allison Lu, Massimiliano Russo, Jeffrey M. Caterino, Michael T. Eadon, Lang Li, Jing Su, Macarius Donneyong, Pengyue Zhang   +14 more
wiley   +1 more source