Results 241 to 250 of about 14,665 (304)

Mechanisms of Lycium barbarum Treatment in Sepsis‐Induced Myocardial Injury: A Network Pharmacology and Experimental Validation Study

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
The chemical characterization of the LB extract confirmed the presence of polysaccharides and specific small‐molecule constituents (e.g., rutin, isoquercitrin). Network pharmacology analysis predicted that the bioactive components of LB were able to interact with core targets such as TP53, AKT1, and JUN, and molecular docking simulations suggested ...
Ruxin Liu, Chunxia Ma, Yujiao Tang, Xue Bai, Liting Yang, Yi Hu, Zesu Niu, Weiliang Xue, Ling Zhang, Mengfei Chen   +9 more
wiley   +1 more source

Bridging evidence worlds: policy and practice pathways for integrating clinical trials and real-world data in drug development and HTA. [PDF]

Front Pharmacol
Sagkriotis A.
europepmc   +1 more source

Development and Release of the Munich UICC Staging Tool (MUST): Advancing UICC Staging in Real‐World Data With Insights From Pancreatic and Stomach Cancer

International Journal of Cancer, Volume 159, Issue 3, Page 757-767, 1 August 2026.
Accurate cancer staging is essential for cancer research and treatment evaluation. However, real‐world data often include incomplete or inconsistent UICC staging classifications. The presented Munich UICC Staging Tool (MUST) automates UICC stage derivation from TNM classifications and tumor characteristics, incorporating novel real‐world data rules to ...
Brigitte Kühnel, Sophie Schneiderbauer, Sebastian Lange, Dirk Wilhelm, Helmut Friess, Marcus Feith, Ursula Ehmer, Florian Bassermann, Julian W. Holch, Stefan M. Munker, Jens Neumann, Jens Werner, Hubert J. Stein, Theres Fey, Ulrich Mansmann, Hana Algül, Karin Berger‐Thürmel, H. Carlo Maurer, Daniel Nasseh   +18 more
wiley   +1 more source

A specific basal forebrain-medial prefrontal cholinergic pathway improves attentional control in male mice. [PDF]

Sci Rep
Fois GR, Medrano MC, Proville R, Caille S, Guillem K.   +4 more
europepmc   +1 more source

Morroniside Attenuates Doxorubicin‐Induced Cardiotoxicity by Activating the PI3K/AKT/Nrf2/HO‐1 Pathway to Inhibit Ferroptosis and Oxidative Stress

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Mor activates the PI3K/AKT pathway to promote Nrf2 nuclear translocation and HO‐1 expression, enhancing antioxidants, curbing Fe2+‐induced ROS/lipid peroxidation, suppressing ferroptosis, and alleviating Dox‐induced cardiotoxicity. ABSTRACT Cardiotoxicity induced by doxorubicin (Dox) significantly contributes to increased mortality among cancer ...
Zhi‐Hui Lin, Xing‐Yu Lin, Wen‐Jie Lu, Meng‐Qi Wu, Dong‐Yan Song, Rui‐Dong Cheng   +5 more
wiley   +1 more source

Cost-effectiveness of integrative oncology for sustainable and patient-centred cancer care: a systematic review in the context of the WHO global traditional medicine strategy 2025-2034. [PDF]

Front Public Health
Schad F, Thronicke A, Reinhold T, Oei SL, Boujnah H, Baldini E, Szőke H, Fuller-Shavel N, Seifert G.   +8 more
europepmc   +1 more source

Inhibiting the Endothelial Mechanosensitive Channel Piezo1 Restores Hippocampal Blood–Brain Barrier Integrity to Improve Anesthesia‐ and Surgery‐Induced Cognitive Decline

MedComm, Volume 7, Issue 8, August 2026.
Approximately 10%–30% of elderly patients develop cognitive decline after surgery. How brain regions coordinate cellular networks to mediate this remains unclear. Anesthesia/surgery induces Piezo1 in hippocampal endothelial cells of aged mice. Endothelial Piezo1 deletion restores BBB integrity and improves cognition.
Yong Qiu, Chunheng Mo, Jinyan Wu, Jiachen Li, Shiyu Xu, Lu Chen, Liyin Zhang, Xingming Huang, Yi Zhang, Meng Sun, Yi Kang, Tao Zhu, Bi‐Sen Ding, Guo Chen   +13 more
wiley   +1 more source

Lenvatinib as Second-Line Regimen after Atezolizumab plus Bevacizumab Combination Therapy. [PDF]

Liver Cancer
Kudo M.
europepmc   +1 more source

Active Safety Surveillance Using Real‐World Evidence (ASSURE) Implementation: Transparent and Reproducible Real‐World Evidence Standardized Framework to Support Safety Signal Evaluation

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 8, August 2026.
ABSTRACT Purpose To summarize experience with Johnson & Johnson's novel Active Safety Surveillance Using Real‐world Evidence (ASSURE) program for producing efficient, transparent, applicable, and impactful RWE to support routine pharmacovigilance processes.
Kevin Haynes, Jenna Reps, Jill Hardin, Eva‐Maria Didden, James Gilbert, Joel Swerdel, Justin Bohn, Mitchell M. Conover, Amir Sarayani, Anthony G. Sena, Emily Yost, Valerie van Baalen, Kourtney Davis, Patrick Ryan, Martijn Schuemie   +14 more
wiley   +1 more source

Advancing real-world data integration in nursing research: A policy perspective on Japan's next-generation medical infrastructure law and the EU EHDS framework. [PDF]

Jpn J Nurs Sci
Kubota K, Ishibashi S.
europepmc   +1 more source