Results 221 to 230 of about 14,665 (304)

Use of RWD in the assessment of economic evaluations of innovative health products: lessons learned from the French National Authority for health (HAS). [PDF]

Int J Technol Assess Health Care
Ghabri S, Sion M.
europepmc   +1 more source

Single‐Cell RNA Sequencing Reveals Disrupted Stromal–Epithelial Crosstalk Impairs Gut Barrier in Depression

Brain and Behavior, Volume 16, Issue 8, August 2026.
scRNA‐seq atlas of the depressed mouse colon reveals that expansion of disease‐specific cCF1 and CTF stromal subsets disrupts epithelial homeostasis via enhanced TGF‐ß and suppressed WNT/ß‐catenin signaling, impairing stem cell function, differentiation, and intestinal barrier integrity.
Xiao‐Song Xu, Wan‐Ning Zhang, Xu‐Rui Hao, Xiao‐Yu Liu, Hong‐Chen Yu, Cai‐Xia Jia, Jian‐Ming Jiang, De‐Zhi Kong, Yan‐Ru Cai   +8 more
wiley   +1 more source

Editorial: Advancement of RWD/RWE utilization for enhancing drug development and benefit/risk assessment. [PDF]

Front Pharmacol
Uyama Y, Bérard A, Chan KA.
europepmc   +1 more source

Intermittent Hypoxia Exacerbates Lipopolysaccharide‐Induced Neurobehavioral Abnormalities: The Role of Neuroinflammation and Synaptic‐Related Proteins

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background Sepsis is a common systemic inflammatory disease clinically observed in patients with severe trauma or infectious diseases. Lipopolysaccharide (LPS) serves as a classic tool for studying infection‐related neuroinflammation and behavioral changes.
Yi‐Zhu Ding, Zong‐Fang Wang, Chen Dai, Yuan‐Zi Ye   +3 more
wiley   +1 more source

Demonstrating Clinical Performance of the Elecsys Anti-SARS-CoV-2 Anti-Nucleocapsid Immunoassay Using Real-World Data to Support Regulatory Decision-Making in the USA. [PDF]

Infect Dis Ther
Hod EA, Yang B, Magnus C, Rank CM, Yang F, Qiu A, Lipschitz J, Feit Y, Rai AJ, Baumfeld Andre E.   +9 more
europepmc   +1 more source

Chronic Smoking Impairs Glymphatic Transport and Cognitive Function in Adolescent Mice Through Cardiac, Vascular, and Perivascular Aquaporin‐4 Mechanisms

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Chronic smoking during adolescence impairs glymphatic transport, leading to cognitive decline and aberrant accumulation of phosphorylated tau in the hippocampal DG region. Smoking‐induced glymphatic dysfunction compromises synaptogenesis and neurogenesis in the hippocampal DG region.
Chuanxiang Lv, Chengyu Xia, Zean Li, Tao Liu, Zhuang Sha, Shiying Dong, Yu Qian, Mingqi Liu, Kang Zhang, Xinran Zhang, Rongcai Jiang, Li Bie   +11 more
wiley   +1 more source

Legal Basis and Regulatory Requirements for Utilizing Real-World Evidence in Medical Product Regulatory Decision-Making. [PDF]

Pharmacoepidemiol Drug Saf
Park S, Han E.
europepmc   +1 more source

hUC‐MSCs via β‐NGF Alleviate Cognitive Impairment After Tibial Fracture Surgery by Regulating the STMN2/NMNAT2‐SARM1‐NF‐κB Signaling Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
This study found that human umbilical cord mesenchymal stem cells secrete β‐NGF, which binds to the TrkA receptor on neurons, upregulates the protein levels of STMN2 and NMNAT2 in mice with perioperative neurocognitive disorders, and thereby downregulates the protein levels of SARM1 and p‐NF‐κB.
Kai Wang, Fangjun Wang, Yuhan Zhang, Wenbo Li, Shuai Li, Ying Zhou, Guangkuo Ma, Ziwei Xia, Xueyan Zhou, Liwei Wang   +9 more
wiley   +1 more source

BIRTH: Bayesian integration of real-world data for trials with hybrid arms. [PDF]

BMC Med Res Methodol
Wang W, Chen X, Li B, Jiang L, Yan F.
europepmc   +1 more source

CD147‐Conjugated Minocycline Nanomicelles Alleviate Neuroinflammation and Improve Neurological Function Following Intracerebral Hemorrhage

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Schematic illustration of the design and therapeutic mechanism of MINO@PNM@CD147, which enables CD147‐mediated brain‐targeted delivery, suppresses neuroinflammation, alleviates neuronal injury, and enhances neurological recovery following intracerebral hemorrhage (ICH).
Yang Liu, Yun Chen, Yuanyuan Liu, Zhe Li, Qingli Wang, V. Wee Yong, Ruixue Wei, Mengzhou Xue   +7 more
wiley   +1 more source