Results 201 to 210 of about 14,665 (304)

A scoping review on using real-world data to evaluate the effectiveness of mHealth applications. [PDF]

NPJ Digit Med
Gehder S, Brückner S, Gilbert S, Goeldner M.   +3 more
europepmc   +1 more source

Methods Applied to Assess Real-World Effectiveness of Drugs: A Scoping Review. [PDF]

Pharmacol Res Perspect
von Osmanski BI, Petersen J, Petersen CT, Bentsen AH, Jimenez-Solem E, Ankarfeldt MZ.   +5 more
europepmc   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

Imatinib outcomes in chronic myeloid leukemia across diverse health care settings: a systematic review and meta-analysis. [PDF]

Blood Cancer J
Miranda-Galvis M, Wilson J, Reategui-Almonacid Y, Johnston L, Taylor AO, Sadek R, Tjioe K, Cortes JE.   +7 more
europepmc   +1 more source

Big Data in Cancer Genomics: Computational Foundations and Emerging Pathways for Precision Oncology

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT This review aims to explore the computational foundations of big data in cancer genomics and examine emerging pathways that support precision oncology and personalized cancer care. A narrative review approach was adopted to synthesize evidence from PubMed, Scopus, Web of Science, and IEEE Xplore.
Nur Vanu, Nur Mohammad, Fahad Ahmed, Towsif Alam, Koushik Saha, Durga Shahi, Adib Hossain, Mia Md. Tofayel Gonee Manik, Mst. Rina Parvin   +8 more
wiley   +1 more source

Identifying the Initiation of a New Line of Therapy for Metastatic Lung, Breast, and Colorectal Cancer in Real-World Data: A Scoping Review. [PDF]

Pharmacoepidemiol Drug Saf
Onasanya O, Mahmoudpour SH, Bates B, Shui IM, Liu G, Tan EH, Yang YH, Salas M, Fadare J, Bennett D, Drummond PLM, Shin JJ, Guleria S, Wang JR, Hada M, Denis H, Setoguchi S, Truter I, Lopes LC, Dixon RW.   +19 more
europepmc   +1 more source

The suppressor of cytokine signaling 3 regulates glioma stem cell maintenance and immune microenvironment through signal transducer and activator of transcription 3 signaling

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
We found that SOCS3 deficiency activates STAT3 to enhance glioma stem cell (GSC) stemness and survival. We demonstrated that IL‐6 rescues STAT3 signaling and reverses SOCS3‐mediated tumor suppression. We revealed that SOCS3‐low GSCs exhibit enriched p53 and JAK‐STAT pathway activity. This study provides new mechanistic insights into SOCS3‐STAT3 axis in
Jingtao Wang, Gaolei Hou, Zhaofei Song, Kai Gao, Hongbin Wang, Tao Li   +5 more
wiley   +1 more source

Supporting complex mental health care and services research today and beyond: a mini-review of real-world evidence strategies and informed approaches. [PDF]

Front Health Serv
Hendricks-Sturrup RM, Gaspar FW.
europepmc   +1 more source

The role of protein arginine methyltransferases in sickle cell‐mediated neurovascular impairments in mice

British Journal of Pharmacology, Volume 183, Issue 18, Page 5586-5601, September 2026.
Background and Purpose Sickle cell disease (SCD) is a hereditary blood disorder caused by mutation of β‐globin. In SCD, haemoglobin polymerization causes red blood cells to assume a rigid sickle‐shape leading to neurovascular alterations, including development of vascular dementia – characterized by cognitive impairment and reduced cerebral perfusion ...
Julia Zaccarelli‐Magalhães, Mariana Sayuri Berto Udo, Drew James Smith, Julia Langman, Luiz Henrique Matuguma, Guilherme Nagamine Gomes, Peter Rodriguez, Ammar Husan, Quanguang Zhang, Christopher G. Kevil, Cristiane Teresinha Citadin, Hung Wen Lin   +11 more
wiley   +1 more source

Advancing health technology assessment in Taiwan: over 15 years of evidence-based reform, innovation, and patient partnership. [PDF]

Int J Technol Assess Health Care
Huang LY, Lin SY, Liu MH.
europepmc   +1 more source