Cell Proliferation, EarlyView.PCSK9 aggravates AAA by promoting ferroptosis in VSMCs. In the pathological AAA environment, PCSK9 upregulation triggers ferritinophagy‐dependent degradation of FTH1, leading to Fe2+ release, triggering lipid peroxidation and ferroptosis, exacerbating AAA.
Mengdie Xia +13 more
wiley +1 more source
Dynamic Vibration Analysis and Suppression Research of Reamer String While Drilling
Shiyou jixieIn the application of ream while drilling technology， there are still several issues such as severe vibration of drill string system leading to cutter fragmentation and thread joint failure， complex stress state of long string under complex drilling ...
Hou Fuxiang +5 more
doaj
Defining a standards framework for ophthalmology real-world data methodologies through an expert-led Delphi consensus. [PDF]
Eye (Lond)Gabrielle PH +10 more
europepmc +1 more source
Participant recruitment, Pre-existing RWD access, Prospective RWD acquisition and secure storage -v4
D8.3-D8.7, reported in 5 deliverables, each one being an update of the previous one, aim to: (a) reflect the number of participants enrolled prospectively on a biannual basis until the end of the study and verify ethical RWD acquisition following informed consent and IRB approval; (b) document the amount of RWD reflective of our CoBraD Protocol ...
openaire +1 more source
Elevated lymphoma risk in patients with chronic pruritus and chronic prurigo
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Background and objectives Chronic pruritus (CP) and chronic prurigo (CPG, including prurigo nodularis) are prevalent, debilitating diseases with diverse comorbidities, including malignancies. This retrospective cohort study evaluated the prevalence and risk of lymphoma in CP and CPG patients, including key risk factors, and sex‐ and ancestry ...
Svenja Royeck +10 more
wiley +1 more source
Evaluating treatment effectiveness: Complementing RCTs with real-world data. [PDF]
Am J Health Syst PharmRivera CG +3 more
europepmc +1 more source
Participant recruitment, Pre-existing RWD access, Prospective RWD acquisition and secure storage -v1
D8.3-D8.7, reported in 5 deliverables, each one being an update of the previous one, aim to: (a) reflect the number of participants enrolled prospectively on a biannual basis until the end of the study and verify ethical RWD acquisition following informed consent and IRB approval; (b) document the amount of RWD reflective of our CoBraD Protocol ...
openaire +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aim Although finerenone has shown efficacy in randomized trials, evidence from routine clinical practice remains limited. We aimed to assess the real‐world effectiveness and safety of finerenone in people with type 2 diabetes (PWT2D) and chronic kidney disease (CKD), with a particular focus on residual cardiorenal risk as reflected by changes ...
Oscar Moreno‐Pérez +13 more
wiley +1 more source
Maximizing the impact of real-world evidence on cancer treatment: what do we need to achieve it? [PDF]
J Comp Eff ResBermejo B +9 more
europepmc +1 more source
Participant recruitment, Pre-existing RWD access, Prospective RWD acquisition and secure storage -v2
D8.3-D8.7, reported in 5 deliverables, each one being an update of the previous one, aim to: (a) reflect the number of participants enrolled prospectively on a biannual basis until the end of the study and verify ethical RWD acquisition following informed consent and IRB approval; (b) document the amount of RWD reflective of our CoBraD Protocol ...
openaire +1 more source