Results 171 to 180 of about 14,665 (304)

Real-World Evidence for Drug Value Assessment in China: Learning from International Experiences. [PDF]

Drugs Real World Outcomes
Hartzema AG, Gehchan A, Guo JD, Xuan J.
europepmc   +1 more source

RWD insights into the use, safety and effectiveness of novel treatments

Alzheimer's & Dementia
AbstractIn Japan, the regulatory authority approved the drug in September 2023, and on December 20, it became available for prescription country‐wide under the health insurance system. However, there are strict patient, physician, and facility requirements for the prescription of Lecanemab, and various problems are anticipated in its future ...
openaire   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Innovative Clinical Trial Approach for Evaluating Digital Medical Devices Under European Fast-Track Regulatory Frameworks. [PDF]

Stat Med
Ursino M, Boulet S, Collignon C, Francis-Oliviero F, Lhomme E, Porcher R, Saillour F, Varoquaux G, Vercamer V, Thiébaut R, Zohar S.   +10 more
europepmc   +1 more source

COVID-19 RWD processing

Report on the data processing activities related to data harvest curation normalization and validation of the COVID19 data as identified in WP1 Task 31 and Task 32 ...
openaire   +1 more source

RWD insights into the global cost of Alzheimer’s and dementia

Alzheimer's & Dementia
AbstractIt is well recognised that Alzheimer’s disease and related dementia disorders (ADRD) are associated with very high societal costs. The total global costs of dementia have been estimated to over 1.3 trillion US$ annually (Wimo, Seeher et al. 2023).
openaire   +1 more source

Powdered hibiscus anthocyanin‐nanofibril complexes as natural colourants: Stability and application in yoghurt and soft candy

Coloration Technology, EarlyView.
Abstract The instability of anthocyanins limits their application as natural food colorants. This study aimed to enhance the stability of anthocyanins extracted from Hibiscus sabdariffa through copigmentation with protein nanofibrils produced from pea, rice, gluten and whey isolates. Linear and curly nanofibril structures were prepared and incorporated
Vildan Eyiz, İsmail Tontul, Selman Türker   +2 more
wiley   +1 more source

RWD Domain-Containing Protein 3 [PDF]

, 2020
openaire   +1 more source

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source

Editorial: Utilizing real-world evidence for better endocrine health management. [PDF]

Front Endocrinol (Lausanne)
Mei M, Lopes LC, Li C.
europepmc   +1 more source