European Journal of Haematology, EarlyView.ABSTRACT Multiple myeloma (MM) is predominantly a disease of older adults, yet the randomized clinical trials (RCTs) that define standards of care are conducted largely in younger, fitter, and less comorbid populations. This creates a systematic mismatch between the populations generating evidence and those receiving treatment in routine practice ...
Enrica Antonia Martino +13 more
wiley +1 more source
Global Stakeholder Perspectives on Real-World Data and Evidence in Health Technology Assessment: An Exploratory Study. [PDF]
Healthcare (Basel)Zisis K +3 more
europepmc +1 more source
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Applicability of academic real-world data research in the case studies of the HTx project to practical health technology assessment work. [PDF]
Front PharmacolBjörvang C +13 more
europepmc +1 more source
Participant recruitment, Pre-existing RWD access, Prospective RWD acquisition and secure storage -v3
D8.3-D8.7, reported in 5 deliverables, each one being an update of the previous one, aim to: (a) reflect the number of participants enrolled prospectively on a biannual basis until the end of the study and verify ethical RWD acquisition following informed consent and IRB approval; (b) document the amount of RWD reflective of our CoBraD Protocol ...
openaire +1 more source
Application of the toolbox and the repository to unCoVer RWD
Scientific report of its usability and joint publications Task 42 and Task 45 ...
openaire +1 more source
Journal of Fish Biology, EarlyView.Abstract Anadromous salmonids migrate seaward to exploit feeding and growth opportunities in marine habitats, yet how smolt biological characteristics influence their marine migratory behavior remains poorly understood. This study used 9 years of trout (Salmo trutta) population monitoring data from 15,595 tagged age‐0+ parr, 1033 smolts detected ...
Jonathan P. Gillson +11 more
wiley +1 more source
Follow the data: tracking data quality and completeness in oncology real-world data. [PDF]
JAMIA OpenApp SJ +8 more
europepmc +1 more source
R WE ready for reimbursement? A round-up of developments in real-world evidence relating to health technology assessment: part 25. [PDF]
J Comp Eff ResArora P, Ramagopalan SV.
europepmc +1 more source
Modified fin morphology in mackerel icefish (Champsocephalus gunnari) may indicate nesting behaviour
Journal of Fish Biology, EarlyView.Abstract Monitoring reproductive traits in Southern Ocean species is challenging. Males in some channichthyids thicken the epithelium along their anal fins to aid nest construction. This study presents initial evidence that the only commercially harvested channichthyid, mackerel icefish (Champsocephalus gunnari), exhibits modifications to their anal ...
Huw W. James +4 more
wiley +1 more source