Results 211 to 220 of about 14,665 (304)

Modeling Item Responses to Understand Change over Time and Diagnostic Needs in Tandem

Journal of Educational Measurement, Volume 63, Issue 3, Fall 2026.
Abstract Achievement tests are often designed to measure student growth over time using vertical scales while also providing diagnostic information on mastery of specific skill areas. However, traditional assessments rarely integrate psychometric models appropriate for both purposes.
Stephen Tavares, James Soland
wiley   +1 more source

Risk factors for intensive care unit coronavirus disease 2019 pneumonia-associated invasive fungal infections: a Bayesian evidence synthesis integrating external and real-world data. [PDF]

Virol J
Wang C, Gong H, Wang J, Yang T, Wu Y, Wang Y, Cai Y.   +6 more
europepmc   +1 more source

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Assessing Overall Survival Benefits in Advanced Cancers: The Role of External Comparator Cohort Studies with Real-World Data. [PDF]

Clin Pharmacol Ther
Pignatti F, El-Galaly TC, Kaiser M, Porkka K, Doeswijk R, Mol P, Rivera DR, Lerro CC, Rohr UP, Verpillat P, Valachis A, Trapani D, Di Maio M, Latino N, Cordoba R, Cherny N, Koopman M, Martins-Branco D, Pentheroudakis G, Postmus D.   +19 more
europepmc   +1 more source

In Vivo Electrochemical Monitoring of Safinamide Pharmacokinetics in the Brain Explores Its Correlation With Vision‐Related Neuronal Activity

Advanced Science, Volume 13, Issue 43, 3 August 2026.
An electrochemical platform based on differential pulse amperometry enables real‐time, selective tracking of safinamide pharmacokinetics in the living brain with high spatiotemporal resolution. When integrated with electrophysiology, this approach reveals that drug‐induced suppression of vision‐related neuronal activity provides mechanistic insight ...
Xiaoke Nan, Chuqi Li, Qianhe Dai, Junlan Zhou, Lijiao Cao, Yuying Liu, Jinger Chen, Meiping Xiong, Yuhang Jiang, Xianchan Li   +9 more
wiley   +1 more source

Editorial: Utilizing real world data and real world evidence in veterinary medicine: current practices and future potentials. [PDF]

Front Vet Sci
Wright A, Mwacalimba K, Rai T.
europepmc   +1 more source

SCARFISH: A new SCAR action group to co‐ordinate Antarctic fish research

Journal of Fish Biology, EarlyView.
Jilda Alicia Caccavo, Cassandra Brooks, Erica Carlig, Rachel D. Cavanagh, Thomas Desvignes, Davide Di Blasi, Jennifer J. Freer, Laura Ghigliotti, Christopher Jones, Jin‐Hyoung Kim, Hayley Kwasniewski, Rebecca Konijnenberg, Dale Maschette, Mao Mori, Manuel Novillo, Matthew H. Pinkerton, José Pedro Queirós, William D. K. Reid, Anton P. Van de Putte, Julia M. York, SCARFISH members, José Abreu, Sadie Ainsworth, Rajendran Shobha Ajin, Valentina Bernal‐Durán, Emily Alana Burke, César A. Cárdenas, William A.J. Connor, Andrew Corso, Jacob M. Daane, Tracey Dornan, Patrick Eskuche‐Keith, Nur Azalina Suzianti Feisal, Denisse Fierro‐Arcos, Brittany Finucci, Simona Georgieva, Pedro M. Guerreiro, Svenja Halfter, Philip Hollyman, Huw W. James, Mario La Mesa, Felix Mark, Tshoanelo Miya, Noorashikin Noor, Daniela Nualart, Takehiro Okuda, Chiara Papetti, Charlie Plasman, María Lorena Romero Martínez, Francisco Santa Cruz, Julia Saravia, Daniela Storch, Katharina Teschke, Aimee van der Reis, Luis Vargas‐Chacoff, Andrea Walters, Joel Williams, Philippe Ziegler   +57 more
wiley   +1 more source

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, Volume 13, Issue 44, 7 August 2026.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Best Practices and Gaps in Current Regulatory and Health Technology Assessment Real-World Evidence Policies for Medicines and Medical Devices: Current State of Play and Next Steps. [PDF]

Clin Transl Sci
Cresswell K, Claire R, Issa L, Kubehl L, Bilal O, Purcell R, Clemente A, Wested J, Jensen LG, Sasane M, Peeters R, Shinkins B, Colvin H.   +12 more
europepmc   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, Volume 13, Issue 45, 13 August 2026.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source