Results 31 to 40 of about 12,767 (235)

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Improving Web user Experience by Adapting RWD

International Journal of Engineering and Advanced Technology, 2020
Responsive Web Design (RWD) is a design which focuses on responsively fitting in whatever device the website is accessed from. It involves writing code for all possible screen sizes and bundling them together. Hence when the website is accessed, the whole bundle alongside the code for all screen sizes are downloaded to the user’s device and acts ...
K. Naveen Bharathi, M. Kavitha Margret
openaire   +2 more sources

SemantiPack: An Efficient Real-World Data Compressor Using Structural and Semantic Metadata

IEEE Access
The exponential growth of Real-World Data (RWD), primarily collected from IoT sensors and spanning domains such as mobility, environment, and energy consumption, presents critical challenges due to its scale, heterogeneity, and structural variability ...
Yoshiteru Nagata, Daiki Kohama, Yoshiki Watanabe, Shin Katayama, Kenta Urano, Takuro Yonezawa, Nobuo Kawaguchi   +6 more
doaj   +1 more source

Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy

Frontiers in Oncology, 2022
Radiation-induced heart disease (RIHD) is a recent concern in patients with lung cancer after being treated with radiotherapy. Most of information we have in the field of cardiac toxicity comes from studies utilizing real-world data (RWD) as randomized ...
Azadeh Abravan, Azadeh Abravan, Gareth Price, Gareth Price, Kathryn Banfill, Tom Marchant, Matthew Craddock, Matthew Craddock, Joe Wood, Marianne C. Aznar, Marianne C. Aznar, Alan McWilliam, Alan McWilliam, Marcel van Herk, Marcel van Herk, Corinne Faivre-Finn, Corinne Faivre-Finn   +16 more
doaj   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Role of RWD / RWE in health technology assessment

Real-World Data & Evidence, 2023
For many reasons randomized clinical trials today can»t cope with the tasks set by modern health care, which was clearly demonstrated by the COVID-19 pandemic. This gave new impetus to the development of the RWD / RWE. It became obviously that in cases of impossibility, unethical and other reasons, new methods for obtaining high-quality evidence may be
V. G. Borovskaya, A. A. Kurylev
openaire   +2 more sources

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Expert survey on real‐world data utilization and real‐world evidence generation for regulatory decision‐making in drug lifecycle in Korea

Clinical and Translational Science
As the importance of utilizing real‐world data (RWD)/real‐world evidence (RWE) for supporting regulatory scientific decision‐making continues to grow, experiences and inputs from experts become crucial for developing a systematic and practice‐oriented ...
Hankil Lee, Hyeon‐Soo Ahn, Sol Kwon, Hye‐Young Kang, Euna Han   +4 more
doaj   +1 more source

Exploring the influential factors of roadway departure crashes on rural two-lane highways with logit model and association rules mining

International Journal of Transportation Science and Technology, 2021
Roadway departure (RwD) crashes are a major contributor of rural two-lane (R2L) highway crashes and fatalities. For targeted reduction of crashes and fatalities due to roadway departure, a thorough understanding of factors associated with RwD crashes is ...
M. Ashifur Rahman, Xiaoduan Sun, Subasish Das, Sushmita Khanal   +3 more
doaj   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source