Results 71 to 80 of about 27,021 (267)

Maintaining patient registries, on the basis of which regulatory authorities can make decisions regarding medicines

Реальная клиническая практика: данные и доказательства, 2023
The use of data and evidence from real clinical practice (RWD / RWE) is becoming more and more relevant to the healthcare system when making critical decisions in the field of drug circulation regulation, as well as making decisions on the inclusion or ...
A. V. Ivanov, V. N. Semykin
doaj   +1 more source

High-energy emission of fast rotating white dwarfs

, 2005
The process of energy release in the magnetosphere of a fast rotating, magnetized white dwarf can be explained in terms of the canonical spin-powered pulsar model.
Biermann, P. L., Ikhsanov, N. R.
core   +1 more source

External control during RWD/RWE research: a methodological approach

Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice, 2022
At the moment, randomized controlled trials (RCTs) are the gold standard for providing evidence of the effectiveness and safety of medicines. If it is impossible to randomize and create an internal control group, alternative methods of collecting evidence are used, for example, the use of so-called external control groups created, among other things ...
A. A. Zhuravkov, A. S. Kolbin
openaire   +2 more sources

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Nova-like Cataclysmic Variables in the Infrared [PDF]

, 2014
Novalike cataclysmic variables have persistently high mass transfer rates and prominent steady state accretion disks. We present an analysis of infrared observations of twelve novalikes obtained from the Two Micron All Sky Survey, the Spitzer Space ...
Allard, Ballouz, Belle, Beuermann, Beuermann, Beuermann, Bidelman, Bisikalo, Bode, Carciofi, Carolyn S. Brinkworth, Christian Knigge, Ciardi, Cohen, Cowley, Cynthia S. Froning, D'Alessio, D. W. Hoard, David R. Ciardi, Debes, Diaz, Diaz, Dubus, Evans, Evans, Farihi, Gautier, Gerard T. van Belle, Greenstein, Gänsicke, Haro, Harrison, Harrison, Harrison, Hellier, Hoard, Hoard, Hoard, Hoard, Hoard, Hoard, Hoard, Hoard, Honeycutt, Howell, Hutchings, J. E. Drew, Jarrett, Jura, Jura, Jura, Kafka, Kafka, Knigge, Knigge, Knox S. Long, Kraft, Kraicheva, Kunegunda Belle, Lee, Linnell, Linnell, Linnell, Linnell, Linnell, Linnell, Linnell, M. L. Pretorius, Mardirossian, Martínez-Pais, McArthur, Melikian, Melikian, Noebauer, Orosz, Orosz, Patten, Paula Szkody, Pişmiş, Prinja, Proga, Protitch, Protitch, Puebla, Puebla, Qian, Qian, Reach, Ribeiro, Rodríguez-Gil, Rutten, S. Kafka, Skillman, Skrutskie, Smith, Spitzer, Spruit, Stefanie Wachter, Steve B. Howell, Sytov, Taam, Taam, Warner, Warner, Warner, Willems, Willems, Wright, Wright, Wu, Wu, Zuckerman, Zuckerman   +112 more
core   +5 more sources

MES-CoBrad D8.3 Participant recruitment, Pre-existing RWD access, Prospective RWD acquisition and secure storage -v1

, 2022
The Multidisciplinary Expert System for the Assessment & Management of Complex Brain Disorders (MES-CoBraD) project integrates a group of professionals with inter-expertise and where a wide number of different fields of research interact. Four centres from the collaborative effort, have agreed to incorporate participant data, ranging from clinical ...
openaire   +1 more source

Facilitating Expedited Drug Approval– the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, Accepted Article.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Cross-sectional analysis of use of real-world data in single technology appraisals of oncological medicine by the National Institute for Health and Care Excellence in 2011–2021

BMJ Open
Objectives This study aims to identify how real-world data (RWD) have been used in single technology appraisals (STAs) of cancer drugs by the National Institute for Health and Care Excellence (NICE).Design Cross-sectional study of NICE technology ...
Jiyeon Kang, John Cairns
doaj   +1 more source

V3885 Sagittarius: a Comparison with a Range of Standard Model Accretion Disks

, 2009
A $\widetilde{\chi}^2$ analysis of standard model accretion disk synthetic spectrum fits to combined $FUSE$ and STIS spectra of V3885 Sagittarius, on an absolute flux basis, selects a model that accurately represents the observed SED.
Barrett, Paul E., Godon, Patrick, Hubeny, Ivan, Linnell, Albert P., Sion, Edward M., Szkody, Paula   +5 more
core   +1 more source