Results 201 to 210 of about 2,484 (221)

Engineering and characterization of a long half-life relaxin receptor RXFP1 agonist

2022
Abstract Relaxin-2 is a peptide hormone with important roles in human cardiovascular and reproductive biology. Its ability to activate cellular responses such as vasodilation, angiogenesis, and anti-inflammatory and anti-fibrotic effects have led to significant interest in using relaxin-2 as a therapeutic for heart ...
Sarah C. Erlandson, Jialu Wang, Haoran Jiang, Howard A. Rockman, Andrew C. Kruse   +4 more
openaire   +1 more source

1698 PRESENCE OF RXFP1 RECEPTORS IN PEYRONIE'S DISEASE PLAQUE TISSUE

Journal of Urology, 2012
evaluated by using ANCOVA. Chi square test was used to evaluate the association between existence or direction of curvature and ED. RESULTS: A total of 220 patients with PD underwent penile Doppler ultrasound assessment between 2008-2010. The mean age of the patients was 55.0 9 and 69.5% had vasculogenic ED (10% arteriogenic, 43.2% venogenic and 16.4 ...
Ronak Gor, Michael Hanzly, Richard Blatter, Timothy Cooney, Justine Schober, Michael Metro   +5 more
openaire   +1 more source

RXFP1 Is Expressed on the Sperm Acrosome, and Relaxin Stimulates the Acrosomal Reaction of Human Spermatozoa

Annals of the New York Academy of Sciences, 2009
The function of relaxin in human reproductive processes remains poorly understood. Nevertheless, relaxin is produced by the prostate in men and by the corpora lutea of ovaries and endometrium in women. Previous studies with contrasting results have suggested a possible role of relaxin on sperm function and fertilization.
GIANESELLO, LISA, FERLIN, ALBERTO, MENEGAZZO M, PEPE A, FORESTA, CARLO   +4 more
openaire   +3 more sources

Targeting RXFP1 by Ligustilide: A novel therapeutic approach for alcoholic hepatic steatosis

International Immunopharmacology
Ligustilide (Lig) is the main active ingredient of Umbelliferae Angelicae Sinensis Radix (Chinese Angelica) and Chuanxiong Rhizoma (Sichuan lovase rhizome). Lig possesses various pharmacological properties and could treat obesity by regulating energy metabolism.
Hong-Xu, Yang, Xue-Li, Jiang, Rong-Mei, Zuo, Yan-Ling, Wu, Ji-Xing, Nan, Li-Hua, Lian   +5 more
openaire   +2 more sources

1769-P: Development of Adipose Fibrosis and Dysfunction in Aged Rxfp1-/- Mice

Diabetes, 2019
The hormone relaxin has roles in insulin sensitivity and age-related fibrosis in several organs, but the effect on adipose is unknown. Given the association of adipose fibrosis to dysfunction and progression of metabolic disease, we analyzed adipose tissue in aged mice lacking the relaxin receptor RXFP1.
ROBERT BENNETT, FREDERICK HAMEL, RONDA L. SIMPSON, ALEXANDER I. AGOULNIK   +3 more
openaire   +1 more source

RXFP1

2021
openaire   +1 more source

Alpha-adrenergic activation upregulates expression of relaxin receptor RXFP1 in cardiomyocytes.

Annals of the New York Academy of Sciences, 2009
Cardiac RXFP1 was upregulated upon activation of the alpha(1)-adrenergic receptor (AR) through signal pathways involving protein kinase A and C and ERK. In contrast, beta(1)-AR activation downregulated expression of cardiac RXFP1 and it further counteracted the alpha(1)-AR-mediated RXFP1 upregulation.
Xiao-Lei, Moore, Alice, Hong, Xiao-Jun, Du   +2 more
openaire   +1 more source

Relaxin Receptor-LGR7 (RXFP1)

2008
Andrew L. Gundlach, Loretta Piccenna
openaire   +1 more source

The anti‐fibrotic actions of relaxin are mediated through AT 2 R‐associated protein phosphatases via RXFP1‐AT 2 R functional crosstalk in human cardiac myofibroblasts

FASEB Journal, 2020
Chao Wang, Anita A Pinar, Robert E Widdop   +2 more
exaly  

RXFP1

2018
openaire   +1 more source