Results 181 to 190 of about 31,472 (217)
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Structure and function of ryanodine receptors
American Journal of Physiology-Cell Physiology, 1994Membrane depolarization, neurotransmitters, and hormones evoke a release of Ca2+ from intracellular Ca(2+)-storing organelles like the endoplasmic reticulum and, in muscle, the sarcoplasmic reticulum (SR). In turn, the released Ca2+ serves to trigger a variety of cellular responses.
R, Coronado +3 more
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Ryanodine receptors as leak channels
European Journal of Pharmacology, 2014Ryanodine receptors are Ca(2+) release channels of internal stores. This review focuses on those situations and conditions that transform RyRs from a finely regulated ion channel to an unregulated Ca(2+) leak channel and the pathological consequences of this alteration.
Agustín, Guerrero-Hernández +2 more
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Ryanodine receptors in smooth muscle
Frontiers in Bioscience, 2002The sarcoplasmic reticulum (SR) of smooth muscle is endowed with two different types of Ca2+ release channels, i.e. inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs). In general, both release channels mobilize Ca2+ from the same internal store in smooth muscle.
Agustín, Guerrero-Hernández +3 more
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Electron Microscopy of Ryanodine Receptors
2010Publisher Summary This chapter reviews the contributions of cryo-electron microscopy (cryo-EM) and single-particle three-dimensional reconstruction (3D cryo-EM) to understanding the structural architecture of ryanodine receptors (RyRs). 3D reconstructions at about 1-nm resolution are determined for RyRs in putatively open and closed states, and ...
Terence C, Wagenknecht, Zheng, Liu
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Increasing Ryanodine Receptor Open Probability Alone Does Not Produce Arrhythmogenic Calcium Waves
Circulation Research, 2007Andrew Trafford, David Eisner
exaly