Results 171 to 180 of about 31,472 (217)

Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy. [PDF]

J Cachexia Sarcopenia Muscle
Souidi M, Resta J, Dridi H, Sleiman Y, Reiken S, Formoso K, Colombani S, Amédro P, Meyer P, Charrabi A, Vincenti M, Liu Y, Soni RK, Lezoualc'h F, Stéphane Blot DVM, Rivier F, Cazorla O, Parini A, Marks AR, Mialet-Perez J, Lacampagne A, Meli AC.   +21 more
europepmc   +1 more source

The Effect of Acidic Residues on the Binding between Opicalcin1 and Ryanodine Receptor from the Structure-Functional Analysis. [PDF]

J Nat Prod
Yao J, Hua X, Huo W, Xiao L, Wang Y, Tang Q, Valdivia CR, Valdivia HH, Dong W, Xiao L.   +9 more
europepmc   +1 more source

Correction to: Ryanodine receptor remodeling in cardiomyopathy and muscular dystrophy caused by lamin A/C gene mutation. [PDF]

Hum Mol Genet
europepmc   +1 more source

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Ryanodine Receptor as Insecticide Target

Current Pharmaceutical Design, 2022
: The ryanodine receptor (RyR) is one of the primary targets of commercial insecticides. The diamide insecticide family, including flubendiamide, chlorantraniliprole, cyantraniliprole, etc., targets insect RyRs and can be used to control a wide range of destructive agricultural pests.
Han Zuilhof, Hadiatullah Hadiatullah
exaly   +3 more sources

Ryanodine receptors

Cell Calcium, 2005
RyRs are large homotetrameric proteins that are approximately 4/5 cytoplasmic and approximately 1/5 transmembrane and luminal in mass. Mutations in RyRs produce human disease and many of these disease-causing mutations are in the cytoplasmic domains. To elucidate the mechanisms of a disease and to develop interventions, it is crucial to determine how ...
Stephan Lehnart, Xander Wehrens, Andrew Marks   +2 more
  +6 more sources

Ryanodine Receptors

2023
The ryanodine receptor (RyR) is the largest known channel, named for specifically binding the alkaloid ryanodine. It is a homotetramer with high conductance for monovalent and divalent cations. Although not very Ca2+ selective, RyRs function as a Ca2+ release channel from the sarco/endoplasmic reticulum, amplifying the initial Ca2+ signaling from the ...
Benitah, Jean-Pierre, Pereira, Laetitia, Yin, Liheng, Mercadier, Jean-Jacques, Gandon-Renard, Marine, Val-Blasco, Almudena, Perrier, Romain, Gómez, Ana Maria   +7 more
openaire   +1 more source

Ryanodine receptor channelopathies

Biochemical and Biophysical Research Communications, 2004
Ryanodine receptors (RyR) are the Ca2+ release channels of sarcoplasmic reticulum that provide the majority of the [Ca2+] necessary to induce contraction of cardiac and skeletal muscle cells. In their cellular environment, RyRs are exquisitely regulated by a variety of cytosolic factors and accessory proteins so that their output signal (Ca2+) induces ...
Nancy A, Benkusky, Emily F, Farrell, Héctor H, Valdivia   +2 more
openaire   +2 more sources

Muscling in on the ryanodine receptor

Nature Structural & Molecular Biology, 2015
The ryanodine receptor (RyR), an ion channel regulating intracellular calcium release in excitable cells, has been challenging for structural analysis because of its colossal proportions compared to most other ion channels. Three independent groups have now used recent technological advancements in single-particle cryo-EM to make giant strides in ...
Ivana Y, Kuo, Barbara E, Ehrlich
openaire   +2 more sources

Role of Ryanodine Receptors

Critical Reviews in Biochemistry and Molecular Biology, 1994
Recent findings on the ryanodine receptor of vertebrates, a Ca-release channel protein for the caffeine- and ryanodine-sensitive Ca pools, are reviewed in this article. Three distinct genes, i.e., ryr1, ryr2, and ryr3, express different isoforms in specific locations: Ryr1 in skeletal muscle and Purkinje cells of cerebellum; Ryr2 in cardiac muscle and ...
openaire   +2 more sources