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Flecainide Specifically Targets the Monovalent Countercurrent Through the Cardiac Ryanodine Receptor, While a Dominant Opposing Ca²⁺/Ba²⁺ Current Is Present. [PDF]

Int J Mol Sci
Gaburjakova J, Domsicova M, Poturnayova A, Gaburjakova M.   +3 more
europepmc   +1 more source

Correction to: Ryanodine receptor remodeling in cardiomyopathy and muscular dystrophy caused by lamin A/C gene mutation. [PDF]

Hum Mol Genet
europepmc   +1 more source

Role of ryanodine receptor cooperativity in Ca²⁺-wave-mediated triggered activity in cardiomyocytes. [PDF]

J Physiol
Zhong M, Karma A.
europepmc   +1 more source

Purinergic agonists increase [Ca²⁺]_i in rat conjunctival goblet cells through ryanodine receptor type 3.

Am J Physiol Cell Physiol
Fjaervoll HK, Fjaervoll KA, Yang M, Reiten OK, Bair J, Lee C, Utheim TP, Dartt D.   +7 more
europepmc   +1 more source

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Ryanodine Receptor

Encyclopedia of Molecular Pharmacology, 2021
T. Murayama, N. Kurebayashi, H. Ogawa
semanticscholar   +3 more sources

Ryanodine receptors

Cell Calcium, 2005
RyRs are large homotetrameric proteins that are approximately 4/5 cytoplasmic and approximately 1/5 transmembrane and luminal in mass. Mutations in RyRs produce human disease and many of these disease-causing mutations are in the cytoplasmic domains. To elucidate the mechanisms of a disease and to develop interventions, it is crucial to determine how ...
Stephan Lehnart, Xander Wehrens, Andrew Marks   +2 more
  +6 more sources

Ryanodine receptor channelopathies

Biochemical and Biophysical Research Communications, 2004
Ryanodine receptors (RyR) are the Ca2+ release channels of sarcoplasmic reticulum that provide the majority of the [Ca2+] necessary to induce contraction of cardiac and skeletal muscle cells. In their cellular environment, RyRs are exquisitely regulated by a variety of cytosolic factors and accessory proteins so that their output signal (Ca2+) induces ...
Nancy A, Benkusky, Emily F, Farrell, Héctor H, Valdivia   +2 more
openaire   +2 more sources

Ryanodine receptor dysfunction in human disorders.

Biochimica et biophysica acta. Molecular cell research, 2018
Regulation of intracellular calcium (Ca2+) is critical in all cell types. The ryanodine receptor (RyR), an intracellular Ca2+ release channel located on the sarco/endoplasmic reticulum (SR/ER), releases Ca2+ from intracellular stores to activate critical
Alexander Kushnir, Benjamin Wajsberg, A. Marks   +2 more
semanticscholar   +1 more source