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Structural basis for diamide modulation of ryanodine receptor
Nature Chemical Biology, 2020R. Ma +15 more
semanticscholar +1 more source
Ryanodine receptors as leak channels
European Journal of Pharmacology, 2014Ryanodine receptors are Ca(2+) release channels of internal stores. This review focuses on those situations and conditions that transform RyRs from a finely regulated ion channel to an unregulated Ca(2+) leak channel and the pathological consequences of this alteration.
Agustín, Guerrero-Hernández +2 more
openaire +2 more sources
Modulation of cardiac ryanodine receptor 2 by calmodulin
Nature, 2019D. Gong +9 more
semanticscholar +1 more source
Electron Microscopy of Ryanodine Receptors
2010Publisher Summary This chapter reviews the contributions of cryo-electron microscopy (cryo-EM) and single-particle three-dimensional reconstruction (3D cryo-EM) to understanding the structural architecture of ryanodine receptors (RyRs). 3D reconstructions at about 1-nm resolution are determined for RyRs in putatively open and closed states, and ...
Terence C, Wagenknecht, Zheng, Liu
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Methylxanthines and Ryanodine Receptor Channels
2010Methylxanthines of either natural or synthetic origin have a number of interesting pharmacological features. Proposed mechanisms of methylxanthine-induced pharmacological effects include competitive antagonism of G-coupled adenosine A(1) and A(2A) receptors and inhibition of phosphodiesterases.
Serge, Guerreiro +2 more
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
exaly
Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2
Science, 2016W. Peng +7 more
semanticscholar +1 more source