Results 281 to 290 of about 2,365,951 (330)
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Ryanodine receptors in smooth muscle
Frontiers in Bioscience, 2002The sarcoplasmic reticulum (SR) of smooth muscle is endowed with two different types of Ca2+ release channels, i.e. inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs). In general, both release channels mobilize Ca2+ from the same internal store in smooth muscle.
Agustín, Guerrero-Hernández +3 more
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Critical Reviews in Biochemistry and Molecular Biology, 1994
Recent findings on the ryanodine receptor of vertebrates, a Ca-release channel protein for the caffeine- and ryanodine-sensitive Ca pools, are reviewed in this article. Three distinct genes, i.e., ryr1, ryr2, and ryr3, express different isoforms in specific locations: Ryr1 in skeletal muscle and Purkinje cells of cerebellum; Ryr2 in cardiac muscle and ...
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Recent findings on the ryanodine receptor of vertebrates, a Ca-release channel protein for the caffeine- and ryanodine-sensitive Ca pools, are reviewed in this article. Three distinct genes, i.e., ryr1, ryr2, and ryr3, express different isoforms in specific locations: Ryr1 in skeletal muscle and Purkinje cells of cerebellum; Ryr2 in cardiac muscle and ...
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Ryanodine receptor gene expression thymomas
Muscle & Nerve, 1998Ryanodine receptor (RyR) antibodies are present in sera of myasthenics with thymoma, and their titer correlates with morbidity and mortality. We investigated whether skeletal muscle RyR expression in thymic tissues could be the source of immune sensitization to the RyR.
L L, Kusner, A, Mygland, H J, Kaminski
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Structural basis for diamide modulation of ryanodine receptor
Nature Chemical Biology, 2020R. Ma +15 more
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Ryanodine receptors as leak channels
European Journal of Pharmacology, 2014Ryanodine receptors are Ca(2+) release channels of internal stores. This review focuses on those situations and conditions that transform RyRs from a finely regulated ion channel to an unregulated Ca(2+) leak channel and the pathological consequences of this alteration.
Agustín, Guerrero-Hernández +2 more
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Electron Microscopy of Ryanodine Receptors
2010Publisher Summary This chapter reviews the contributions of cryo-electron microscopy (cryo-EM) and single-particle three-dimensional reconstruction (3D cryo-EM) to understanding the structural architecture of ryanodine receptors (RyRs). 3D reconstructions at about 1-nm resolution are determined for RyRs in putatively open and closed states, and ...
Terence C, Wagenknecht, Zheng, Liu
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Modulation of cardiac ryanodine receptor 2 by calmodulin
Nature, 2019D. Gong +9 more
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Methylxanthines and Ryanodine Receptor Channels
2010Methylxanthines of either natural or synthetic origin have a number of interesting pharmacological features. Proposed mechanisms of methylxanthine-induced pharmacological effects include competitive antagonism of G-coupled adenosine A(1) and A(2A) receptors and inhibition of phosphodiesterases.
Serge, Guerreiro +2 more
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