Results 81 to 90 of about 2,684,234 (246)

Voltage-dependent modulation of cardiac ryanodine receptors (RyR2) by protamine.

PLoS ONE, 2009
It has been reported that protamine (>10 microg/ml) blocks single skeletal RyR1 channels and inhibits RyR1-mediated Ca2+ release from sarcoplasmic reticulum microsomes.
Paula L Diaz-Sylvester, Julio A Copello
doaj   +1 more source

Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes

Cell Death and Disease, 2010
Overactivation of ionotropic glutamate receptors in oligodendrocytes induces cytosolic Ca2+ overload and excitotoxic death, a process that contributes to demyelination and multiple sclerosis.
Asier Ruiz, C. Matute, Elena Alberdi
semanticscholar   +1 more source

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source

Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression

Nature Communications
Ryanodine receptor 1 Ca2+ leak is a signal in skeletal muscle, but chronic leak can underlie pathology. Here we show that in healthy male mouse, limb-girdle muscle presents higher sympathetic input, elevated ryanodine receptor 1 basal phosphorylation ...
Aldo Meizoso-Huesca, Cedric R. Lamboley, James R. Krycer, Mark P. Hodson, James E. Hudson, Bradley S. Launikonis   +5 more
doaj   +1 more source

Dopamine D1 Receptors Participate in Cocaine-Induced Place Preference via Regulation of Ryanodine Receptor Expression

Journal of Pharmacological Sciences, 2011
.: Ryanodine receptors (RyRs) with three different isoforms in the brain play a role to facilitate Ca2+ release from the intracellular Ca2+ pool. Although cocaine is a strongly addictive psychostimulant that dramatically affects the central nervous ...
Kazuhiro Kurokawa, Koji Mizuno, Masahiro Shibasaki, Seitaro Ohkuma   +3 more
doaj   +1 more source

A new approach to an old disease: Ageing, arrhythmogenic substrate and the role of risk‐factor modification in atrial fibrillation

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) prevalence rises sharply with age due to two independent mechanisms. Ageing produces irreversible arrhythmogenic substrate changes through progressive fibrosis, cellular senescence and mitochondrial dysfunction, while modifiable risk factors such as obesity, hypertension, sleep apnoea, diabetes and alcohol use promote ...
Udit Thakur, Jonathan M. Kalman
wiley   +1 more source

The interaction of ryanoids with individual ryanodine receptor channels

Biological Research, 2004
Ryanodine binds with high affinity and specificity to a class of Ca2+-release channels known as ryanodine receptors (RyR). The interaction with RyR results in a dramatic alteration in function with open probability (Po) increasing markedly and rates of ...
ALAN J WILLIAMS, BHAVNA TANNA
doaj  

Regulatory Mechanisms and Pathophysiological Significance of IP3 Receptors and Ryanodine Receptors in Drug Dependence

Journal of Pharmacological Sciences, 2013
Calcium is a ubiquitous intracellular signaling molecule required for initiating and regulating neuronal functions. Ca2+ release from intracellular stores in the endoplasmic reticulum into intracellular spaces via intracellular Ca2+–releasing channels ...
Koji Mizuno, Kazuhiro Kurokawa, Seitaro Ohkuma   +2 more
doaj   +1 more source

Sirtuin signalling governs calcium homeostasis and mitochondrial function in metabolic syndrome cardiomyocytes

Experimental Physiology, EarlyView.
Abstract Metabolic syndrome (MetS) is a major contributor to cardiovascular disease and is characterized by impaired Ca2+ handling and mitochondrial dysfunction in cardiomyocytes. However, the upstream mechanisms linking metabolic stress to these alterations remain incompletely defined.
Firat Akat, Leila Aryan, Suatnur Şık, Erkan Tuncay   +3 more
wiley   +1 more source

Increase of Type 2 Ryanodine Receptors in Mouse Nucleus Accumbens in the Development and Expression of Morphine-Induced Place Preference

Journal of Pharmacological Sciences, 2014
.: The present study investigated the effect of ryanodine receptors (RyRs) in the development and expression of morphine-induced conditioned place preference (CPP).
Kazuhiro Kurokawa, Koji Mizuno, Seitaro Ohkuma   +2 more
doaj   +1 more source