Results 61 to 70 of about 2,684,234 (246)

AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor

Nature Communications, 2017
In this work the authors show that AIP (aryl hydrocarbon receptor-interacting protein), a gene frequently mutated in association with pituitary tumors, regulates neurotransmitter release by inhibiting calcium release from ryanodine receptors.
Bojun Chen, Ping Liu, Edward J. Hujber, Yan Li, Erik M. Jorgensen, Zhao-Wen Wang   +5 more
doaj   +1 more source

Prenatal Hypoxia Induced Dysfunction in Cerebral Arteries of Offspring Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundHypoxia during pregnancy could cause abnormal development and lead to increased risks of vascular diseases in adults. This study determined angiotensin II (AII)‐mediated vascular dysfunction in offspring middle cerebral arteries (MCA).
Jiaqi Tang, Na Li, Xueyi Chen, Qinqin Gao, Xiuwen Zhou, Yingying Zhang, Bailin Liu, Miao Sun, Zhice Xu   +8 more
doaj   +1 more source

Role of Leaky Neuronal Ryanodine Receptors in Stress-Induced Cognitive Dysfunction

Cell, 2012
Summary The type 2 ryanodine receptor/calcium release channel (RyR2), required for excitation-contraction coupling in the heart, is abundant in the brain.
Xiaoping Liu, Matthew J. Betzenhauser, S. Reiken, A. Meli, Wenjun Xie, Bi-xing Chen, O. Arancio, A. Marks   +7 more
semanticscholar   +1 more source

Myasthenia Gravis and Thymoma

Muscle &Nerve, EarlyView.
ABSTRACT Thymoma is the most common tumor of the anterior mediastinum. Approximately 20%–30% of patients with a thymoma develop myasthenia gravis (MG), and an additional one third may possess positive acetylcholine receptor (AChR) antibodies without MG.
Benjamin Claytor, Lukas Delasos, Daniel P. Raymond, Erik Seroogy, Jason Lempel, Yuebing Li   +5 more
wiley   +1 more source

Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability

Cell Reports, 2019
Summary: The excitability of CA1 hippocampal pyramidal cells is mediated by a slow AHP (sAHP) that responds to calcium increases by Cav1 calcium channels and ryanodine receptors (RyR).
Giriraj Sahu, Rima-Marie Wazen, Pina Colarusso, S.R. Wayne Chen, Gerald W. Zamponi, Ray W. Turner   +5 more
doaj   +1 more source

A mathematical model for the effects of amyloid beta on intracellular calcium. [PDF]

PLoS ONE, 2018
The accumulation of Alzheimer's disease (AD) associated Amyloid beta (Aβ) oligomers can trigger aberrant intracellular calcium (Ca2+) levels by disrupting the intrinsic Ca2+ regulatory mechanism within cells.
Joe Latulippe, Derek Lotito, Donovan Murby   +2 more
doaj   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

RNAi‐based functional genomics tools for the beet leafhopper using microinjection and nanoparticle‐based topical spray

Insect Science, EarlyView.
• First demonstration of functional RNAi in the beet leafhopper, Neoaliturus tenellus, using both dsRNA microinjection and star polycation nanoparticle‐mediated topical spray delivery.•Microinjection achieved over 90% knockdown of Gus and Pum3, revealing gene‐specific fitness effects on survival and fecundity in beet leafhopper.•Nanoparticle‐mediated ...
Jinlong Han, Maria Paula Mejia Alonzo, Meihua Cui, Katherine O. Puffer, Anna M. Wolff, Garret M. Miyake, Oliver T. Neher, Vamsi J. Nalam, Punya Nachappa   +8 more
wiley   +1 more source

Persistence of pro-arrhythmic spatio-temporal calcium patterns in atrial myocytes: a computational study of ping waves

Frontiers in Physiology, 2012
Clusters of ryanodine receptors within atrial myocytes are confined to spatially separated layers. In many species, these layers are not juxtaposed by invaginations of the plasma membrane, so that calcium-induced-calcium signals rely on centripetal ...
Rüdiger eThul, Stephen eCoombes, Martin D Bootman, Martin D Bootman   +3 more
doaj   +1 more source

The Airway Transcriptome in Type 2 Cytokine Biomarker‐High and ‐Low Severe Asthma

Allergy, EarlyView.
This study distinguishes severe asthma–related airway transcriptomic changes from the effects of high‐dose ICS. Most dysregulated genes in severe asthma show concordance with corticosteroid responses. Corticosteroid‐resistant T2‐high asthma featured T2‐high and epithelial barrier gene upregulation, while T2‐low asthma featured Th1/IL‐17 signatures. ASM,
Jiashu Shen, Rekha Chaudhuri, Stephen Bicknell, Adel H. Mansur, Rahul Shrimanker, Ian D. Pavord, Stephen J. Fowler, Vanessa Brown, Lorcan P. McGarvey, Peter H. Howarth, Sven‐Erik Dahlén, Ian M. Adcock, Nazanin Zounemat‐Kermani, Joseph R. Arron, Liam G. Heaney, David F. Choy, Timothy S. C. Hinks, Emanuele Marchi, Peter Bradding, on behalf of the UK Medical Research Council Refractory Asthma Stratification programme (RASP‐UK)   +19 more
wiley   +1 more source