Results 111 to 120 of about 136,524 (172)

The mutual effects on safety and immunogenicity of combined vaccination with 15-valent pneumococcal conjugate vaccine and adsorbed acellular DPT in 3-month healthy infants: A randomized, open-label, controlled, phase III clinical trial. [PDF]

Hum Vaccin Immunother
Lu-Lu P, Hong-Ze M, Zhao G, Min-Jie L, Wen-Jian F, Ya-Nan L, Wang B, Shao-Xin W, Shi G, Li-Na G, Li B, Ying Z, Lin D, Qi L.   +13 more
europepmc   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

A novel method for depletion of dengue virus non-structural protein 1 antibodies to determine serotype exposure history. [PDF]

mSphere
Zheng YY, Morwitzer MJ, McCracken MK, Friberg H, Gromowski GD, Currier JR.   +5 more
europepmc   +1 more source

Enterovirus infections in children

Pediatric Investigation, EarlyView.
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen, Lingyun Guo, Xiaobo Lei, Linqing Zhao, Mingyan Hei, Jun Shen, Ju Yin, Fei Li, Jikui Deng, Gang Liu, Yong Zhang, Zhengde Xie   +11 more
wiley   +1 more source

Invasive pneumococcal disease by serotype 23B in an asplenic unvaccinated patient: A case report. [PDF]

IDCases
Tanaka Y, Hayashi K, Abe Y, Uesaka S, Maeda H, Suzuki A, Nakaya Y, Takamura Y, Sato M, Kobayashi Y, Sakamaki I.   +10 more
europepmc   +1 more source

Botulinum toxin use in patients with neurological disorders: A U.S.‐based claims database analysis

PM&R, EarlyView.
Abstract Background and Objective Real‐world evidence describing long‐term persistency with botulinum toxin (BoNT) therapy is limited. We assessed treatment patterns and persistency with BoNT in clinical practice over 2 years. Design Retrospective, longitudinal, claims database analysis. Setting Medical claims data from the Merative MarketScan database
David M. Simpson, Jonathan Bouchard, Simon Page, Seth Goldfarb, Atul T. Patel   +4 more
wiley   +1 more source

Cross-serotype immunity elicited by a consensus dengue NS1 mRNA vaccine in mice. [PDF]

PLoS One
Tharakhet K, Prompetchara E, Khawsang C, Saithong S, Kaewpang P, Yostrerat N, Wangsoontorn P, Sontikun J, Tantratorn S, Khotprathum T, Lam K, Heyes J, Weissman D, Ruxrungtham K, Ketloy C.   +14 more
europepmc   +1 more source

Cordycepin Alleviates Non Alcoholic Fatty Liver Disease Progression by Stabilizing GCH1 to Inhibit Ferroptosis

Phytotherapy Research, EarlyView.
COR stabilizes GCH1 and inhibits ferroptosis. ABSTRACT To investigate the effects and targets of cordycepin (COR) in alleviating non‐alcoholic fatty liver disease (NAFLD). High‐fat diet was used to induce NAFLD in mice, and after COR gavage administration, changes in liver function, glucose and lipid metabolism, and ferroptosis‐related signaling were ...
Chenyang Han, Jian Sheng, Hongyan Pei, Wenyan Li, Shasha Wu, Yi Yang, Chenxi Cao, Zhiling Tang   +7 more
wiley   +1 more source

Dengue Surge in Bangladesh: Exploring the Role of Climate Factors-A Narrative Review With Ecological Analysis. [PDF]

Health Sci Rep
Amin MA, Manna RM, Nahin S, Hawlader MDH.   +3 more
europepmc   +1 more source

Protosappanin A Alleviates Atherosclerosis by Regulating the MDM2/GPX4 Axis‐Mediated Endothelial Ferroptosis

Phytotherapy Research, EarlyView.
PTA alleviates atherosclerosis by regulating the MDM2/GPX4 axis‐mediated endothelial ferroptosis. ABSTRACT Endothelial ferroptosis is a crucial pathogenic driver of atherosclerosis (AS) progression. Protosappanin A (PTA), a bioactive compound from Caesalpinia sappan L., protects cardiovascular vessels by regulating ferroptosis.
Jiamei Fu, Lin Zhu, Wenwei Yang, Mengnan Li, Zhixin Wu, Shude Sun, Yabin Zhou   +6 more
wiley   +1 more source