Results 51 to 60 of about 151,000 (163)

Impact of C18 Epimerization of Indole‐ and Pyrazole‐Fused 18β‐Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies

ChemMedChem, Volume 20, Issue 22, November 18, 2025.
The indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
Ledy De‐la‐Cruz‐Martínez, Rosendo Martínez‐Arellano, Mitzi López‐Sánchez, José G. Alvarado‐Rodríguez, Jesús Martin Torres‐Valencia, David Equihua‐González, Julio‐César Almanza‐Pérez, Jaime Pérez‐Villanueva, Martín González‐Andrade, José C. Páez‐Franco, Francisco Cortés‐Benítez   +10 more
wiley   +1 more source

Dendrímeros: Macromoléculas versátiles con interés interdisciplinar. [PDF]

, 2016
Los dendrímeros son una clase especial de polímeros que presentan estructuras bien definidas, altamente ramificadas en su interior y con numerosos grupos funcionales en la superficie.
Alonso Garrido, Beatriz, Casado, Carmen
core   +1 more source

La química médica como fuente de identificación y optimización de compuestos útiles en la biología molecular y celular. Ligandos de tubulina en el sitio de unión de colchicina como agentes antivasculares tumorales. [PDF]

, 2015
La química médica es una ciencia altamente multidisciplinar que abarca desde el diseño, identificación, síntesis y optimización de compuestos biológicamente activos a la interpretación de su modo de acción a nivel molecular. Por ello constituye un puente
Pérez Pérez, María Jesús
core  

Reactivity of Square Planar Pt(II) Complexes Toward Acidic Moieties as H+, M+, and [ML]+ (M = Ag, Au)

Chemistry – A European Journal, Volume 31, Issue 59, October 22, 2025.
Despite the fact that Pt(II) in square‐planar complexes exhibits Lewis basic properties toward electrophilic species (E⁺), the presence of oxygen atoms acting as competing Lewis basic sites leads to the formation of Pt─O─E⁺─O─Pt or Pt─O─E⁺ type complexes, in which no direct metal–metal bonds are observed.
Laura Martínez‐Romera, David Campillo, Daniel Escudero, Miguel Baya, Antonio Martín   +4 more
wiley   +1 more source

Synthesis of conformationally restricted glutamate and glutamine derivatives from carbonylation of orthopalladated phenylglycine derivatives

Beilstein Journal of Organic Chemistry, 2012
A new method for the regioselective synthesis of 2-alkoxycarbonyl- and 2-(aminocarbonyl)phenylglycinate methyl esters has been developed. The reaction of the orthopalladated complex [Pd(μ-Cl)(C6H4(CH(CO2Me)NMe2)-2)]2 (1) with nucleophiles HNu under a CO ...
Esteban P. Urriolabeitia, Eduardo Laga, Carlos Cativiela   +2 more
doaj   +1 more source

Synthesis of Novel Dihydropyridine‐Iminium Salts Containing a Selenazine Core

Asian Journal of Organic Chemistry, Volume 14, Issue 10, October 2025.
An efficient method to develop novel dihydropyrido[3,2‐e][1,3]selenazines iminium salts. A comparative study of the key reagent selenourea towards thiourea and urea was carried out to assess the contribution of chalcogen to the pathway. DFT (density functional theory) calculations have predicted the optimized minimum energy structure for the hybrid ...
Reinier Lemos, Mauro De Nisco, Yoana Pérez‐Badell, Gabriella Pinto, Marco Morelli, Margarita Suárez, Silvana Pedatella   +6 more
wiley   +1 more source

El Compromiso de enseñar química con criterios de sostenibilidad: la química verde [PDF]

, 2009
Los beneficios que aporta la química a la sociedad son muchos, sin embargo no goza de gran aceptación popular. La enseñanza de la química orientada a criterios de sostenibilidad podría mejorar su aceptación social y su interés.
González Arce, M. Luz, Valea, Angel
core  

Insights into the Base‐Stabilized Silylene Nature of the IrSi Bond in Ir(III)–(κ2‐NSi) Complexes with 2‐Quinolone and 2‐Pyridone Type Ligands

European Journal of Inorganic Chemistry, Volume 28, Issue 27, September 29, 2025.
Density functional theory calculations (natural bond orbital and quantum theory of atoms in molecules analyses) on Ir–(κ2‐NSi) complexes with 2‐quinolone and 2‐pyridone derived ligands indicate that the bond is best described as a base‐stabilized silylene. The silicon environment is the key for determining the nature of the IrSi bond.
Marina Padilla, María Batuecas, Pilar García‐Orduña, Luis A. Oro, Francisco José Fernández‐Alvarez   +4 more
wiley   +1 more source

La química de l'or i les seves aplicacions catalítiques, amb Antonio Echavarren [PDF]

, 2011
Antonio Echavarren dirigeix un grup de recerca a l'Institut Català d'Investigació Química (ICIQ) de Tarragona, estudiant l'activitat catalítica de l'or en la síntesi de molècules de gran importància per a la indústria farmacèutica.
Mora Casanova, Jordi
core   +1 more source

Importancia de la química descriptiva en la enseñanza de la química : propuesta de un modelo para su aprendizaje [PDF]

, 1990
This paper tries to establish a methodology for teaching Descriptive Chemistry by applying basic Principles and the social dimension of Chemistry in a stimulating way.
Llopis Castelló, Rafael, Quílez Pardo, Juan   +1 more
core   +2 more sources