Sensing of cardiolipin exposure on plasma membranes of apoptotic cells by EryA‐mCherry protein
The FEBS Journal, EarlyView.An aegerolysin protein erylysin A (EryA) fused with mCherry binds to artificial lipid vesicles supplemented with cardiolipin (CL). This binding is much more specific than that of annexin V, which binds various negatively charged glycerophospholipids (PG, PS, PI). In mammalian cells, the CL exposition at the membrane surface represents an early hallmark
Luka Žeželj +12 more
wiley +1 more source
Artificial lipidation of proteins and peptides: from mechanism to clinical applications
The FEBS Journal, EarlyView.Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley +1 more source
A supramolecular assembly of cone‐specific G‐protein and cryptochrome 4a on lipid bilayer
The FEBS Journal, EarlyView.Immobilized phospholipid bilayers on a sensor chip surface serve as membrane platform to investigate critical protein–lipid and protein–protein interaction processes by surface plasmon resonance. The putative magnetoreceptor cryptochrome 4a and the myristoylated cone‐specific G‐protein α‐subunit (Gtα) bind with high affinity to immobilized lipid ...
Ümmügülsüm Güzelsoy‐Flügge +3 more
wiley +1 more source
A predicted amphipathic helix contributes to the efficient S-acylation of the Arabidopsis thaliana Calcineurin B-like protein 2 [PDF]
, 2023 Thomas Wyganowski +2 more
openalex +1 more source
Heterogeneity of iridoid biosynthesis in catmints: Molecular background in a phylogenetic context
Journal of Integrative Plant Biology, EarlyView.Evolutionary gains and losses of key biosynthetic genes likely resulting from multiple independent evolutionary events explain why certain Nepeta (catnip) species produce both the active, cat‐attracting nepetalactones and sugar‐bound iridoids, while others make only the sugar‐bound forms, and some have lost iridoid production entirely.
Tijana Banjanac +15 more
wiley +1 more source
The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis
Journal of Periodontal Research, EarlyView.Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis +2 more
wiley +1 more source
The endoplasmic reticulum-localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins. [PDF]
J Biol Chem, 2023 Salaun C, Tomkinson NCO, Chamberlain LH.
europepmc +1 more source
Proteome-Scale Analysis of Protein S-Acylation Comes of Age
, 2020 Yang Wang, Wei Yang
openalex +2 more sources
Engineering 2‐Pyrone‐4,6‐Dicarboxylic Acid Production Reveals Metabolic Plasticity of Poplar
Plant Biotechnology Journal, EarlyView.ABSTRACT Woody biomass is a promising source of fermentable sugars for biofuels and bio‐based chemicals, but its industrial use is limited by the costly biorefinery process. A viable strategy to reduce costs involves enhancing both biomass processability and the generation of high‐value co‐products.
Nidhi Dwivedi +7 more
wiley +1 more source