Results 171 to 180 of about 37,335 (238)

Deciphering protein long-chain <i>S</i>-acylation using mass spectrometry proteomics strategies. [PDF]

RSC Chem Biol
Nederstigt AE, Sardana S, Baggelaar MP.
europepmc   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

S-acylation of Ca2+ transport proteins: molecular basis and functional consequences. [PDF]

Biochem Soc Trans
Néré R, Kouba S, Carreras-Sureda A, Demaurex N.   +3 more
europepmc   +1 more source

Evaluation of the Safety, Efficacy and Pharmacokinetics of BGM0504 in Chinese Adults With Type 2 Diabetes: A Multicentre, Randomised, Controlled and Double‐Blind Phase II Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7073-7082, August 2026.
ABSTRACT Aim This study aimed to evaluate its safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy in Chinese adults with T2DM and to preliminarily compare its efficacy and safety with semaglutide through multiple subcutaneous injections. Materials and Methods In this multicentre, randomised, placebo‐controlled and semaglutide‐positive‐
Ping Jin, Linong Ji, Yangqing Huang, Haifeng Ding, Daosheng Xie, Xiaohui Jiang, Xuemei Yuan, Zhao Cao, Haibin Zhang, Jiandong Yuan   +9 more
wiley   +1 more source

A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation. [PDF]

Nat Biotechnol
Ocasio CA, Baggelaar MP, Sipthorp J, Losada de la Lastra A, Tavares M, Volarić J, Soudy C, Storck EM, Houghton JW, Palma-Duran SA, MacRae JI, Tomić G, Carr L, Downward J, Eggert US, Tate EW.   +15 more
europepmc   +1 more source

Periodontitis and Endotoxemia: Clinical and Microbiological Insights

Journal of Clinical Periodontology, Volume 53, Issue 8, Page 1344-1354, August 2026.
ABSTRACT Aim Endotoxemia has been proposed as a link between periodontitis and systemic complications through the translocation of lipopolysaccharide (LPS) from inflamed periodontal sites into the bloodstream. This study aimed to investigate subgingival and serum LPS activities and their correlations with periodontal clinical and microbiological ...
Anbo Dong, Muhammed Manzoor, Jaakko Leskelä, Jukka Putaala, Eija Könönen, Yi Jin, Pirkko Pussinen, Susanna Paju, Svetislav Zaric   +8 more
wiley   +1 more source

Correction to: Differential Effects of Prenylation and S-Acylation on Type I and II ROPS Membrane Interaction and Function. [PDF]

Plant Physiol
europepmc   +1 more source

Root hair plasticity in cereals under abiotic stress

New Phytologist, Volume 251, Issue 4, Page 1684-1693, August 2026.
An integrative perspective on how to study the regulation of root hair plasticity to increase the resilience of cereals to abiotic stress. Summary Abiotic stress is a constant threat to crop growth and yield in the context of climate change. Root systems that can best adapt their architecture to environmental challenges contribute to enhanced ...
Yaping Zhou, Frank Hochholdinger
wiley   +1 more source

Dynamic S-acylation controls CMG2 maturation, extracellular matrix regulation, and anthrax toxin entry

Abrami L, Blaskovic S, Joliot O, Mercier V, Kunz B, Mesquita FS, van der Goot FG.   +6 more
europepmc   +1 more source