Improved Polymer Hemocompatibility for Blood-Contacting Applications via S-Nitrosoglutathione Impregnation. [PDF]
ACS Appl Mater Interfaces, 2022 Blood-contacting medical devices (BCMDs) are inevitably challenged by thrombi formation, leading to occlusion of flow and device failure. Ideal BCMDs seek to mimic the intrinsic antithrombotic properties of the human vasculature to locally prevent ...
Griffin L +5 more
europepmc +2 more sources
S-Nitrosoglutathione Reverts Dietary Sucrose-Induced Insulin Resistance [PDF]
Antioxidants, 2020 The liver is a fundamental organ to ensure whole-body homeostasis, allowing for a proper increase in insulin sensitivity from the fast to the postprandial status.
Inês Sousa-Lima +4 more
doaj +2 more sources
S-Nitrosoglutathione-Based Nitric Oxide-Releasing Nanofibers Exhibit Dual Antimicrobial and Antithrombotic Activity for Biomedical Applications. [PDF]
Macromol Biosci, 2021 The novel use of nanofibers as a physical barrier between blood and medical devices has allowed for modifiable, innovative surface coatings on devices ordinarily plagued by thrombosis, delayed healing, and chronic infection.
Douglass M +5 more
europepmc +2 more sources
Current overview of S-nitrosoglutathione (GSNO) in higher plants [PDF]
Frontiers in Plant Science, 2013 S-nitrosoglutathione is a nitric oxide-derived molecule, generated by the interaction of nitric oxide (NO) with reduced glutathione (GSH) in a process called S-nitrosylation (Figure 1). The reaction appears to take place either through the formation of N2O3 or the addition of NO to a glutathionyl radical formed during this reaction (Broniowska et al ...
Francisco Javier Corpas +2 more
doaj +4 more sources
Localization of S-nitrosoglutathione and expression of S-nitrosoglutathione reductase in pea plants under cadmium stress [PDF]
Journal of Experimental Botany, 2006 S-nitrosoglutathione (GSNO) is considered a natural nitric oxide (NO.) reservoir and a reactive nitrogen intermediate in animal cells, but little is known about this molecule and its metabolism in plant systems. In this work, using pea plants as a model system, the presence of GSNO in collenchyma cells was demonstrated by an immunohistochemical method.
FRANCISCO J Corpas +2 more
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A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies [PDF]
Nanomaterials, 2023 As a potential therapeutic agent, the clinical application of S-nitrosoglutathione (GSNO) is limited because of its instability. Therefore, different formulations have been developed to protect GSNO from degradation, delivery and the release of GSNO at a
Hui Ming +6 more
doaj +2 more sources
S-nitrosoglutathione reductase alleviates morphine analgesic tolerance by restricting PKCα S-nitrosation [PDF]
Redox BiologyMorphine, a typical opiate, is widely used for controlling pain but can lead to various side effects with long-term use, including addiction, analgesic tolerance, and hyperalgesia.
Ling-Yan Su +10 more
doaj +2 more sources
Evidence for an Allosteric S-Nitrosoglutathione Binding Site in S-Nitrosoglutathione Reductase (GSNOR). [PDF]
Antioxidants (Basel), 2019 Current research has identified S-nitrosoglutathione reductase (GSNOR) as the central enzyme for regulating protein S-nitrosylation. In addition, the dysregulation of GSNOR expression is implicated in several organ system pathologies including respiratory, cardiovascular, hematologic, and neurologic, making GSNOR a primary target for pharmacological ...
Fontana K +8 more
europepmc +4 more sources
The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy
Critical Reviews in Biochemistry and Molecular Biology, 2017 S-nitrosoglutathione reductase (GSNOR), or ADH5, is an enzyme in the alcohol dehydrogenase (ADH) family. It is unique when compared to other ADH enzymes in that primary short-chain alcohols are not its principle substrate.
Scott Barnett, Iain Buxton
exaly +2 more sources
S-nitrosoglutathione preserves vasodilation and attenuates myocardial ischemia-reperfusion injury [PDF]
Scientific ReportsIschemia/reperfusion (I/R) injury exacerbates myocardial damage following acute myocardial infarction, underscoring the need for effective cardioprotective therapies. S-nitrosoglutathione (GSNO), an endogenous S-nitrosothiol, functions as a nitric oxide (
Daniele Mendes Guizoni +5 more
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