Results 121 to 130 of about 2,167,990 (301)
Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang +12 morewiley +1 more sourceIMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourceSomatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen +5 morewiley +1 more sourceCombined results of searches for the standard model Higgs boson in pp collisions at √s = 7 TeV
, 2012 S. Chatrchyan, R. Erbacher, C. A. C. Montoya, W. Carvalho, M. Górski, D. Kotlinski, J. Anderson, B. Ujvari, S. Ozturk, A. Polatoz, S. Khalil, Young-Il Choi, R. Hadjiiska, Anil Singh, W. Johns, L. Ceard, P. Hove, A. Iorio, U. Heintz, A. Thea, P. Killewald, T. Mäenpää, M. Ataç, J. Komaragiri, J. Molnár, F. Würthwein, M. Giunta, P. Miné, D. Liang, A. Richards, M. Rodozov, M. Tytgat, D. Gyun, R. Schöfbeck, L. Pape, J. Hirschauer, A. Nürnberg, B. Bilki, K. Sim, F. Yumiceva, M. Bakırcı, E. E. Kangal, C. Jorda, C. Rovelli, D. Fasanella, R. Hirosky, J. Sanabria, A. Meyer, H. Reithler, L. Pant, M. Grothe, T. Lindén, J. Pálinkás, G. Selvaggi, A. Santocchia, B. Caponeri, R. Trayanov, E. Gülmez, A. Falkiewicz, C. Justus, A. Papageorgiou, W. Zeuner, J. Gonzalez, R. G. Cassagnac, G. Daskalakis, R. Rahmat, K. Kao, E. Migliore, M. Souza, T. Rohe, M. Llatas, M. Junior, N. Cavallo, C. Saout, A. Magnan, A. Adair, Y. Assran, A. Holzner, T. Ling, P. Fabbricatore, Kai-Feng Chen, M. Nguyen, D. Stickland, G. Apollinari, Ashish Kumar, M. Felcini, D. Lelas, M. Negra, A. Lath, J. Rodriguez, P. Lujan, A. Sirunyan, M. Mulders, F. Palla, K. Hoffmann, L. Uplegger, S. Bansal, R. Walsh, H. Schettler, V. Krychkine, S. Khalid, K. Hahn, P. Traczyk, N. Pietsch, W. Gabella, W. Bertl, A. Korpela, G. Stephans, Alicia Calderon, T. Peiffer, E. L. Lopez, H. Jo, M. Bontenackels, T. Kress, G. Karapostoli, F. Ptochos, N. Beni, J. Wickens, M. Baarmand, W. Hopkins, A. Petrilli, J. Hays, K. Petridis, Mingming Yang, M. Cepeda, G. Hammad, W. D. Teo, J. Chou, M. Mahmoud, P. Petkov, P. L. Pardo, D. Piccolo, H. Teng, M. Guchait, P. Barbaro, F. Odorici, P. Verdier, R. Betts, V. Innocente, Zong-Kai Liu, Hyunchul Kim, A. Rácz, P. Baillon, V. Savrin, M. Marone, J. Lazo-Flores, J. Salfeld-Nebgen, R. Conway, A. Perloff, A. Safonov, L. Bäni, D. Krücker, S. Tkaczyk, I. Shreyber, A. Martelli, A. Sánchez-Hernández, G. Merino, L. Rebane, A. Heister, D. Majumder, I. Caballero, Fan Yang, K. Beernaert, S. Banerjee, S. Taroni, C. Dragoiu, A. Massironi, T. Ma, D. Lange, R. Guida, M. Boutemeur, I. Bloch, G. Cappello, H. Gamsizkan, C. Kleinwort, L. Millischer, P. Wittich, G. Abbiendi, M. Paulini, D. Figueiredo, S. Chuang, E. Meschi, P. Lariccia, S. Piperov, J. Hernández, L. Wendland, G. Ryu, Y. Iiyama, V. Petrov, R. Plestina, E. Daubie, L. Dudko, M. Turner, A. Nikitenko, G. Kaussen, K. Burkett, L. Spiegel, K. Nirunpong, R. Demina, Arun Kumar, W. Luo, D. Krofcheck, T. Peltola, E. Friis, M. Hohlmann, H. Heath, S. Ahuja, A. Olbrechts, C. Lagana, T. Miao, I. Cruz, G. Wrochna, S. Wasserbaech, J. Whitmore, A. Kraan, D. Winn, E. Butz, B. Mangano, R. Loveless, A. Dermenev, M. Savina, D. Horvath, A. Tiko, T. Orimoto, A. Gritsan, R. Yohay, W. Lohmann, R. A. Manzoni, D. Cline, F. Fiori, B. Radburn-Smith, P. Ribeiro, Yi Chen, A. Panagiotou, L. Gutay, I. Smirnov, F. Geurts, C. Florez, M. Wayne, F. Thyssen, T. Kurca, B. Parida, G. Mantovani, P. Symonds, M. Zielinski, M. Cutajar, M. Zeinali, M. Issah, Kai Yi, W. A. Khan, J. Yun, A. Schmidt, F. Navarria, M. Schröder, M. Djordjevic, D. Claes, C. Civinini, A. Kamenev, M. Serin, K. Kanishchev, M. Marionneau, R. Kelley, D. Pellett, I. Papadopoulos, L. Wehrli, D. Renker, P. Paolucci, D. Cerci, R. Castello, Javier Mauricio Duarte, L. Moroni, G. Lungu, M. Albrow, E. Auffray, K. Nawrocki, J. Conway, Zongchang Yang, I. Fisk, P. Garcia-Abia, P. M. R. Árbol, D. Montanino, O. Gutsche, D. Evans, C. Rogan, A. Güth, Q. Ingram, J. Robles, E. Salvati, G. Cerminara, Y. Chung, Z. Kim, M. Sani, R. Musenich, D. Abbaneo, P. Sphicas, Willis Lin, A. Korablev, M. Niegel, M. Chadwick, S. Maselli, B. Cruz, A. Sparrow, M. Kirakosyan, E. Tuovinen, C. Tully, G. Masetti, D. Son, S. Kwan, Sungho Yoon, T. Pree, R. Patel, T. S. Anjos, H. Mermerkaya, J. Ribnik, C. Bernet, C. Shepherd-Themistocleous, G. Cerizza, S. My, D. Moon, E. Torassa, R. Houtz, A. Markou, C. Jeong, Y. Sirois, V. Matveev, W. Erdmann, V. Ciulli, M. Pelliccioni, F. Cavallari, G. Codispoti, N. Manna, P. Chang, Wenbo Li, C. Newsom, S. A. Koay, S. Shrestha, J. Bernardini, K. Kovitanggoon, J. Ellison, L. Benussi, K. Mazumdar, A. Pozdnyakov, N. Wickramage, C. Jessop, A. Moeller, M. Snowball, V. Chetluru, V. Mossolov, Shih-Chang Lee, S. Evstyukhin, M. Searle, J. Gomez, K. Krajczár, E. Schlieckau, M. Reyes-Santos, I. Golutvin, M. Krämer, J. Hanlon, N. Zaganidis, C. Don, A. Meneguzzo, E. Tiras, C. D. Martins, T. Rodrigo, K. Banzuzi, T. Aziz, F. Meijers, N. Beaupere, A. Kamel, D. Toback, G. Mesyats, M. Diemoz, B. Choudhary, A. Ozpineci, V. Bhatnagar, G. Benelli, G. Anagnostou, T. Bergauer, S. Bitioukov, S. Malik, J. Wagner-Kuhr, M. Klute, A. Belyaev, M. Hansen, S. Metson, R. Remington, L. M. Villasenor-Cendejas, I. Sfiligoi, G. Mohanty, W. Adam, D. Gerbaudo, P. D. Luckey, J. Flix, S. Troshin, Kenneth Smith, G. Sguazzoni, M. Margoni, M. Gruttola, N. Tambe, P. Kyberd, Werner Sun, Hannes Jung, B. Alver, K. Kaadze, D. Bloch, M. Pernicka, L. Cremaldi, A. Hervé, T. Pearson, D. Kovalskyi, Kun-song Chen, M. Zoeller, L. Tauscher, V. Halyo, C. Charlot, E. Wenger, D. Puigh, C. Hartl, G. Bencze, L. Antonelli, D. Trocino, H. Newman, A. Ershov, C. Barth, C. Asawatangtrakuldee, M. Arenton, D. Vázquez, L. Teodorescu, G. Fedi, S. Boutle, D. Barge, G. G. Ceballos, V. Andreev, R. Eusebi, M. Müntel, C. Brew, G. Zumerle, V. Kozhuharov, R. Montalvo, D. Ryckbosch, A. Askew, M. Karim, M. Mattson, I. Shipsey, A. Bell, A. Savin, A. Vartak, D. Gelé, L. Uvarov, H. Bakhshiansohi, B. Betchart, E. Longo, L. Thomas, K. Lassila-Perini, F. Simonetto, R. Suarez, Yu Fu, G. Eckerlin, I. Ojalvo, F. Fabbri, J. D. Campderros, G. Martinez, D. Vishnevskiy, S. Tosi, M. Kasemann, M. Fisher, J. Low, P. Lamichhane, P. Parracho, M. Maggi, R. V. Cortabitarte, Y. Hsiung, J. Goh, C. Seitz, S. Jun, K. Ulmer, V. Kachanov, C. Sander, David Miller, P. Bloch, P. Harris, Y. Tschudi, F. Chlebana, N. Pastika, M. Besançon, J. Hollar, S. Wimpenny, C. Campagnari, L. Sarycheva, C. Contreras-Campana, B. Gomber, C. Nägeli, K. Johnson, J. Coughlan, P. Milenovic, You-Hao Chang, F. Pandolfi, C. Roland, W. Martin, S. Jindariani +499 moresemanticscholar +1 more sourceEstablishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns +10 morewiley +1 more sourceDifferential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales +11 morewiley +1 more sourceCCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets +12 morewiley +1 more sourceCD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu +8 morewiley +1 more source
