Results 151 to 160 of about 2,167,990 (301)
Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht +14 morewiley +1 more sourceMITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson +13 morewiley +1 more sourceA novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz +9 morewiley +1 more sourceOncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan +13 morewiley +1 more sourcePredicting functional remission after antipsychotic discontinuation: a real-world study in schizophrenia. [PDF]
Psychol MedLu C, Dong Y, Zhai Z, Gao T, Luo M, Chang D, Chen J, Xue J, Zhao Y, Xiang Q, Li X, Ma X, Wei Z, Feng T, Liu D. +14 moreeuropepmc +1 more sourceThe ALICE experiment at the CERN LHC
, 2003 K. Aamodt, A. Quintana, R. Achenbach, S. Acounis, D. Adamová, C. Adler, M. Aggarwal, F. Agnese, G. Rinella, Z. Ahammed, A. Ahmad, N. Ahmad, S. Ahmad, A. Akindinov, P. Akishin, D. Aleksandrov, B. Alessandro, R. Alfaro, G. Alfarone, A. Alici, J. Alme, T. Alt, S. Altinpinar, W. Amend, C. Andrei, Y. Andres, A. Andronic, G. Anelli, M. Anfreville, V. Angelov, A. Anzo, C. Anson, T. Anticic, V. Antonenko, D. Antonczyk, F. Antinori, S. Antinori, P. Antonioli, L. Aphecetche, H. Appelshäuser, V. Aprodu, M. Arba, S. Arcelli, A. Argentieri, N. Armesto, R. Arnaldi, A. Arefiev, I. Arsene, A. Asryan, A. Augustinus, T. Awes, J. Äystö, M. D. Azmi, S. Bablock, A. Badalà, S. Badyal, J. Baechler, S. Bagnasco, R. Bailhache, R. Bala, A. Baldisseri, A. Baldit, J. Ban, R. Barbera, P. Barberis, J. Barbet, G. Barnafoldi, V. Barret, J. Bartke, D. Bartoş, M. Basile, V. Basmanov, N. Bastid, G. Batigne, B. Batyunya, J. Baudot, C. Baumann, I. Bearden, B. Becker, J. Belikov, R. Bellwied, E. Belmont-Moreno, A. Belogianni, S. Belyaev, A. Benato, J. Beney, L. Benhabib, F. Benotto, S. Beolè, I. Berceanu, A. Bercuci, E. Berdermann, Y. Berdnikov, C. Bernard, R. Berny, J. Berst, H. Bertelsen, L. Betev, A. Bhasin, P. Baskar, A. Bhati, N. Bianchi, J. Bielcik, J. Bielčíková, L. Bimbot, G. Blanchard, F. Blanco, D. Blau, C. Blume, S. Blyth, M. Boccioli, A. Bogdanov, H. Boggild, M. Bogolyubsky, L. Boldizsár, M. Bombara, C. Bombonati, M. Bondila, D. Bonnet, V. Bonvicini, H. Borel, F. Borotto, V. Borshchov, Y. Bortoli, O. Borysov, S. Bose, L. Bosisio, M. Botje, S. Böttger, G. Bourdaud, O. Bourrion, S. Bouvier, A. Braem, M. A. Braun, P. Braun-Munzinger, L. Bravina, M. Bregant, G. Bruckner, R. Brun, E. Bruna, O. Brunasso, G. Bruno, D. Bucher, V. Budilov, D. Budnikov, H. Buesching, P. Buncic, M. Burns, S. Burachas, O. Busch, J. Bushop, Xu Cai, H. Caines, F. Calaon, M. Caldogno, I. Cali, P. Camerini, R. Campagnolo, M. Campbell, X. Cao, G. Capitani, G. Romeo, M. Cárdenas-Montes, H. Carduner, F. Carena, W. Carena, P. Cariola, F. Carminati, J. Casado, A. Dı́az, M. Caselle, J. Castellanos, J. Castor, V. Catanescu, E. Cattaruzza, D. Cavazza, P. Cerello, S. Ceresa, V. Erný, V. Chambert, S. Chapeland, A. Charpy, D. Charrier, M. Chartoire, J. Charvet, S. Chattopadhyay, V. Chepurnov, S. Chernenko, M. Cherney, C. Cheshkov, B. Cheynis, P. Chochula, E. Chiavassa, V. Barroso, J. Choi, P. Christakoglou, P. Christiansen, C. H. Christensen, O. Chykalov, C. Cicalò, L. Cifarelli-Strolin, M. Ciobanu, F. Cindolo, C. Cirstoiu, O. Clausse, J. Cleymans, O. Cobanoglu, J. Coffin, S. Coli, A. Colla, C. Colledani, C. Combaret, M. Combet, M. Comets, G. C. Balbastre, Z. C. Valle, G. Contin, J. G. Contreras, T. Cormier, F. Corsi, P. Cortese, F. Costa, E. Crescio, P. Crochet, E. Cuáutle, J. Cussonneau, M. Dahlinger, A. Dainese, H. Dalsgaard, L. Daniel, I. Das, T. Das, A. Dash, R. D. Silva, M. Davenport, H. Daues, A. Caro, G. Cataldo, J. Cuveland, A. Falco, M. Gaspari, P. Girolamo, J. Groot, D. Gruttola, A. Haas, N. Marco, S. Pasquale, P. Remigis, D. Vaux, G. Decock, H. Delagrange, M. D. Franco, G. Dellacasa, C. Dell'olio, D. Dell'Olio, A. Deloff, V. Demanov, E. Denes, G. D’erasmo, D. Derkach, A. Devaux, D. Bari, A. D. Bartelomen, C. Giglio, S. Liberto, A. Mauro, P. Nezza, M. Dialinas, L. Díaz, R. Valdes, T. Dietel, R. Dima, H. Ding, C. Dinca, R. Divià, V. Dobretsov, A. Dobrin, B. Doenigus, T. Dobrowolski, I. Dominguez, M. Dorn, S. Drouet, A. Dubey, L. Ducroux, F. Dumitrache, Eric Dumonteil, P. Dupieux, V. Duță, A. Majumdar, M. Majumdar, Thomas Dyhre, L. Efimov, A. Efremov, D. Elia, D. Emschermann, C. Engster, A. Enokizono, B. Espagnon, M. Estienne, A. Evangelista, D. Evans, S. Evrard, C. Fabjan, D. Fabris, J. Faivre, D. Falchieri, A. Fantoni, R. Farano, R. Fearick, O. Fedorov, V. Fekete, D. Felea, G. Feofilov, A. F. Tellez, A. Ferretti, F. Fichera, S. Filchagin, E. Filoni, C. Finck, R. Fini, E. Fiore, D. Flierl, M. Floris, Z. Fodor, Y. Foka, S. Fokin, P. Force, F. Formenti, E. Fragiacomo, M. Fragkiadakis, D. Fraissard, A. Franco, M. C. Franco, U. Frankenfeld, U. Fratino, S. Fresneau, A. Frolov, U. Fuchs, J. Fujita, C. Furget, M. Furini, M. Girard, J. Gaardhøje, A. Gabrielli, S. Gadrat, M. Gagliardi, A. Gago, L. Gaido, A. Torreira, M. Gallio, E. Gandolfi, P. Ganoti, M. Ganti, J. Garabatos, A. G. López, L. Garizzo, L. Gaudichet, R. Gemme, M. Germain, A. Gheata, M. Gheata, B. Ghidini, P. Ghosh, G. Giolu, G. Giraudo, P. Giubellino, R. Glasow, P. Glassel, E. Ferreiro, C. G. Gutiérrez, L. H. Gonzales-Trueba, S. Gorbunov, Y. Gorbunov, H. Gos, J. Gosset, S. Gotovac, H. Gottschlag, D. Gottschalk, V. Grabski, T. Grassi, H. M. Gray, O. Grebenyuk, K. Grebieszkow, C. Gregory, C. Grigoraş, N. Grion, V. Grigoriev, A. Grigoryan, C. Grigoryan, S. Grigoryan, Y. Grishuk, P. Gros, J. Grosse-Oetringhaus, J. Grossiord, R. Grosso, B. Grynyov, C. Guarnaccia, F. Guber, F. Guérin, R. Guernane, M. Guerzoni, A. Guichard, M. Guida, G. Guilloux, H. Gulkanyan, K. Gulbrandsen, T. Gunji, Anupam Gupta, V. Gupta, H. Gustafsson, H. Gutbrod, C. Hadjidakis, M. Haiduc, G. Hamar, H. Hamagaki, J. Hamblen, J. Hansen, P. Hardy, D. Hatzifotiadou, J. Harris, M. Hartig, A. Harutyunyan, A. Hayrapetyan, D. Hasch, D. Haşegan, J. Hehner, N. Heine, M. Heinz, H. Helstrup, A. Herghelegiu, S. Herlant, G. Corral, N. Herrmann, K. Hetland, P. Hille, H. Hinke, B. Hippolyte, M. Hoch, H. Hoebbel, H. Hoedlmoser, T. Horaguchi, M. Horner, P. Hristov, I. Hrivnácová, S. Hu, C. H. Guo, T. Humanic, A. Hurtado, D. Hwang, J. Ianigro, M. Idzik, S. Igolkin, R. Ilkaev, I. Ilkiv, M. Imhoff, P. Innocenti, E. Ionescu, M. Ippolitov, M. Irfan, C. Insa, M. Inuzuka, C. Ivan, A. Ivanov, M. Ivanov, V. Ivanov, P. Jacobs, A. Jachołkowski, L. Jancurova, R. Janik, M. Jasper, C. Jena, L. Jirden, Daniel Johnson, G. Jones, C. Jørgensen, F. Jouve, P. Jovanovic, A. Junique, A. Jusko, H. Jung, W. Jung, K. Kadija, A. Kamal, R. Kamermans, S. Kapusta, A. Kaidalov, V. Kakoyan, S. Kalcher, E. Kang, J. Kapitán, V. Kaplin, K. Karadzhev, O. Karavichev, T. Karavicheva, E. Karpechev, K. Karpio, A. Kazantsev, U. Kebschull, R. Keidel, Mohsin Khan +499 moresemanticscholar +1 more sourceTumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt +10 morewiley +1 more source
