Results 271 to 280 of about 21,351,086 (309)

The S-phase cytotoxicity of camptothecin

Experimental Cell Research, 1991
The DNA topoisomerase I inhibitor camptothecin (CAM) is selectively cytotoxic to S-phase cells of HL-60, and some other myelogenous leukemic lines. The early effects of cell exposure to 0.05-0.2 micrograms/ml CAM are seen after 2 h; at that time a progressive degradation of DNA in the chromatin of S-phase cells is initiated.
G, Del Bino, P, Lassota, Z, Darzynkiewicz   +2 more
openaire   +2 more sources

Regulation of S Phase

1998
The regulation of S phase can be divided into factors and activities that promote DNA replication at the G1-S boundary and those that prevent DNA replication once a segment of DNA has replicated. Considerable regulation is achieved by the synthesis of new proteins (and mRNA coding for these proteins) essential for DNA replication.
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Checking on DNA damage in S phase

Nature Reviews Molecular Cell Biology, 2004
The precise replication of the genome and the continuous surveillance of its integrity are essential for survival and the avoidance of various diseases. Cells respond to DNA damage by activating a complex network of the so-called checkpoint pathways to delay their cell-cycle progression and repair the defects.
Jiri, Bartek, Claudia, Lukas, Jiri, Lukas   +2 more
openaire   +2 more sources

Cyclin into S Phase

Science's STKE, 2004
Cyclin E functions as the activating subunit of the cyclin-dependent kinase 2 complex, which regulates the initiation of DNA synthesis (S phase) in proliferating cells. However, the phenotypes of cyclin E knockout mice are not identical to those of Cdk2 knockout mice, and so cyclin E may have other functions independent of its interaction with Cdk2 ...
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Nuclear morphology during the S phase

Microscopy Research and Technique, 1998
In order to evaluate at the ultrastructural level the chromatin arrangement during the S phase of the cell cycle, the detection of Bromodeoxyuridine (BrdU) by immunogold has been performed in synchronized 3T3 fibroblasts, regenerating liver, and Friend Leukemia Cells (FLC).
MAZZOTTI G, GOBBI, PIETRO, MANZOLI L, FALCONI M.   +3 more
openaire   +3 more sources

Generalized blocking in S phase by methotrexate

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1988
An attempt was made to enhance the frequency of prometaphase cells for high-resolution-banding studies in untransformed Syrian hamster fibroblasts using a typical methotrexate (MTX) block/bromodeoxyuridine release schedule. The recovery 'wave' was serially sampled and detailed sub-phase analysis made using the replication bands resulting from ...
J R, Savage, R, Prasad
openaire   +2 more sources

Delaying S‐phase progression rescues cells from heat‐induced S‐phase hypertoxicity

Journal of Cellular Physiology, 2001
AbstractThe mechanism by which a cell protects itself from the lethal effects of heat shock and other stress‐inducing agents is the subject of much research. We have investigated the relationship between heat‐induced damage to DNA replication machinery and the lethal effects of heat shock, in S‐phase cells, which are more sensitive to heat shock than ...
R P, VanderWaal, C L, Griffith, W D, Wright, M J, Borrelli, J L, Roti   +4 more
openaire   +2 more sources

S Phase

2023
Caroline M. Li, Robert G. Lingeman, Pouya Haratipour, Long Gu, Jennifer Jossart, J. Jefferson P. Perry, Robert J. Hickey, Linda H. Malkas   +7 more
openaire   +1 more source

Phase transitions in 2D materials

Nature Reviews Materials, 2021
Wenbin Li, Xiaoning Qian, Ju Li
exaly  

Two-dimensional diamonds from sp2-to-sp3 phase transitions

Nature Reviews Materials, 2022
Francesco Lavini, Martin Rejhon, Elisa Riedo   +2 more
exaly