Results 91 to 100 of about 21,633,590 (239)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

eEF1A binding to actin is increased by S₁₁-RNase.

, 2014
(A) A GST-eEF1A fusion protein immobilized on GST resin was mixed with known amounts of purified S11-RNase and/or a commercial bovine actin. GST-eEF1A binds similar amounts of S11-RNase whether actin is present or not but the amount of actin bound by ...
David Morse (14370), Mario Cappadocia (263716), Jonathan Soulard (528111), Nicolas Boivin (528112)   +3 more
core   +1 more source

A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light‐Sensitive R‐Opsin

Advanced Science, EarlyView.
The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang, Chunhua Ren, Zhou Qin, Yimeng Cui, Bingbing Zhang, Peng Luo, Xuan Wang, Yaoqi Xie, Xin Zhang, Aifen Yan, Yang Zhang, Dingding Fan, Yang Liu, Wenjie Pan, Xiao Jiang, Lihong Yuan, Haipeng Qin, David M. Irwin, Chaoqun Hu, Yang Liu, Ting Chen   +20 more
wiley   +1 more source

Clustering of IRE1α depends on sensing ER stress but not on its RNase activity

, 2019
The sensors of the unfolded protein response react to endoplasmic reticulum (ER) stress by transient activation of their enzymatic activities, which initiate various signaling cascades.
Chomistek S., Eletto D., Argon Y., Vargas J., Marrocco I., Blumenthal D., Paton J. C., Ricci D., Dibos M., Iwamoto Y., Boyle S., Paton A. W.   +11 more
core   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Evolution of self-compatibility by a mutant S_m-RNase in citrus

, 2020
Self-incompatibility (SI) is an important mechanism that prevents self-fertilization and inbreeding in flowering plants. The most widespread SI system utilizes S ribonucleases (S-RNases) and S-locus F-boxes (SLFs) as S determinants.
Deng, Xiuxin, Chai, Lijun, Wang, Shaohua, Tao, Mengqin, Chen, Chuanwu, Guo, Wenwu, Larkin, Robert M, Liu, Yuanlong, Xie, Zongzhou, Xu, Qiang, Cao, Zonghong, Zhu, Andan, Xia, Rui, Ye, Junli, Li, Yongping, Liang, Mei, Deng, Chongling, Bosch, Maurice, Liu, Junjie, Yang, Huayan, Franklin-Tong, Vernonica E; id_orcid   +20 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Primary restriction of S-RNase cytotoxicity by a stepwise ubiquitination and degradation pathway in Petunia hybrida. [PDF]

New Phytol, 2021
Zhao H, Song Y, Li J, Zhang Y, Huang H, Li Q, Zhang Y, Xue Y.   +7 more
europepmc   +1 more source

Difference between Mitochondrial RNase P and Nuclear RNase P [Letters to the Editor] [PDF]

, 2001
[Discussion of: Puranam, R. S., and G. Attardi. 2001. The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P. Mol. Cell. Biol. 21:548-561.
Puranam, Ram S., Potuschak, Thomas, Rossmanith, Walter, Attardi, Giuseppe   +3 more
core  

Compartmentalization of S-RNase and HT-B degradation in self-incompatible Nicotiana

, 2006
Pollen - pistil interactions are crucial for controlling plant mating. For example, S-RNase-based self-incompatibility prevents inbreeding in diverse angiosperm species. S-RNases are thought to function as specific cytotoxins that inhibit pollen that has
Sivaguru, M, Ariel Goldraij, Goldraij, A, Sunran Kim, Kim, S, Sonia Vazquez-Santana, Lee, CB, Cruz-García, F, C. Nathan Hancock, Mayandi Sivaguru, Hancock, CN, Christopher B. Lee, Katsuhiko Kondo, Kondo, K, Thomas E. Phillips, Bruce McClure, McClure, B, Felipe Cruz-Garcia, Vazquez-Santana, S, Phillips, TE   +19 more
core   +1 more source