Results 101 to 110 of about 21,633,590 (239)

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Functional equivalence of hairpins in the RNA subunits of RNase MRP and RNase P in Saccharomyces cerevisiae

, 2000
RNase MRP and RNase P are both ribonucleoprotein enzymes performing endonucleolytic cleavage of RNA. RNase MRP cleaves at a specific site in the precursor-rRNA transcript to initiate processing of the 5.8S rRNA.
Epps, N., Fretz, S., Zengel, J. M., Lindahl, L.   +3 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Molecular characteristics of S-RNase alleles as the determinant of self-incompatibility in the style of Fragaria viridis. [PDF]

Hortic Res, 2021
Du J, Ge C, Li T, Wang S, Gao Z, Sassa H, Qiao Y.   +6 more
europepmc   +1 more source

The X-ray structure of the non-covalent dimeric form of S16G,A19P,Q28L,R31C,S32C mutant of RNase A re-opens the question of structure-cytotoxic activity relationship in dimeric RNases

, 2010
Pancreatic ribonucleases, thanks to their ability to degrade RNA, represent potential antitumor therapeutics. It has been suggested that RNases have to reach the cytosol and to avoid the binding of the ribonuclease inhibitor (RI) in order to exert ...
MAZZARELLA, LELIO, SICA, FILOMENA, MERLINO, ANTONELLO, PICONE, DELIA, RUSSO KRAUSS, IRENE, ERCOLE, CARMINE   +5 more
core  

Protein function and interactions in gametophytic self-incompatibility : collaborative recognition of S-RNase in vivo [PDF]

, 2015
My dissertation is based on studies of Gametophytic Self-Incompatibility (GSI), a system that allows plants to reject self pollen while accepting non-self pollen, thus preventing inbreeding and promoting genetic diversity in populations.
Qi, Qinzhou
core   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

Long-read genome sequencing reveals the sequence characteristics of pear self-incompatibility locus

Molecular Horticulture
The S-RNase-based self-incompatibility locus (S-locus) in Petunia species contains 16–20 F-box genes, which collaboratively function in the recognition and subsequent degradation of non-self S-RNases, while distinguishing them from self S-RNase. However,
Chao Gu, Ying Xu, Lei Wu, Xueping Wang, Kaijie Qi, Xin Qiao, Zewen Wang, Qionghou Li, Min He, Shaoling Zhang   +9 more
doaj   +1 more source

Mechanisms underlying the formation of seedlessness in Leigong No. 1 pummelo

Guoshu xuebao
【Objective】Seedlessness is a highly desirable horticultural trait in citrus and has emerged as a major breeding target due to consumer preference for seedless fruit.
ZHOU Rui, FAN Yanjie, YANG Ya, ZHOU Kang, LIU Wei, ZHANG Xiaoping, XIE Kaidong, TANG Zhimin   +7 more
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source